Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Dactolisib 3 72
sigmoid
sigmoid
HCC1806 dactolisib 0 3 72
 8 3.196
0.193
0.0324
0.393
0.437
-0.302
0.579
0.986
2.91e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
BT-549 BX-912 2 72
sigmoid
sigmoid
BT549 BX-912 0 2 72
 8 1.948
1.04
0.33
0.126
0.84
0.329
5.0
0.99
1.01e-06
NA
1.28
0.452
0.892
0.808
0.451
5.0
0.987
2.4e-06
NA
BT-20 Omipalisib 1 72
sigmoid
sigmoid
BT20 omipalisib 0 1 72
 8 2.078
0.00617
-0.729
0.985
0.0283
-0.739
0.596
0.97
2.83e-05
NA
0.00781
0.0157
0.306
0.00685
0.0597
0.96
0.988
1.57e-06
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
BT-549 Dactolisib 2 72
sigmoid
sigmoid
BT549 dactolisib 0 2 72
 8 1.889
0.00968
-0.00862
0.677
0.00884
0.0542
1.27
0.985
3.3e-06
NA
0.0134
0.266
0.48
0.00701
0.305
1.45
0.988
1.53e-06
NA
BT-549 BX-912 1 72
sigmoid
sigmoid
BT549 BX-912 0 1 72
 8 1.839
0.909
0.247
0.157
0.742
0.24
3.23
0.992
5.95e-07
NA
1.2
0.419
0.872
0.698
0.415
3.25
0.988
1.54e-06
NA
HCC38 Dactolisib 2 72
sigmoid
sigmoid
HCC38 dactolisib 0 2 72
 8 2.120
0.0118
-0.0557
0.668
0.0118
-0.00134
0.785
0.98
7.61e-06
NA
0.0145
0.204
0.447
0.00701
0.245
0.927
0.988
1.88e-06
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
BT-20 ZSTK474 2 72
sigmoid
sigmoid
BT20 ZSTK474 0 2 72
 8 1.787
0.286
-0.19
0.347
0.373
-0.234
1.46
0.992
4.53e-07
NA
0.391
0.199
0.743
0.29
0.184
1.55
0.988
1.84e-06
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
BT-549 PIK-93 1 72
sigmoid
sigmoid
BT549 PIK-93 0 1 72
 8 1.777
Inf
0.691
0.0438
1.77
0.561
1.47
0.989
1.31e-06
NA
Inf
0.742
0.963
1.64
0.646
1.47
0.988
1.83e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
BT-20 Torin1 2 72
sigmoid
sigmoid
BT20 Torin1 0 2 72
 8 1.793
0.00766
-0.152
0.806
0.00992
-0.146
0.986
0.986
2.59e-06
NA
0.0131
0.215
0.421
0.00727
0.212
0.936
0.988
1.92e-06
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC70 Omipalisib 2 72
sigmoid
sigmoid
HCC70 omipalisib 0 2 72
 8 1.682
0.00746
-0.705
1.01
0.0241
-0.703
0.749
0.991
6.69e-07
NA
0.0135
0.0399
0.359
0.0121
0.0458
0.852
0.989
1.45e-06
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA