Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
BT-20 Omipalisib 3 72
sigmoid
sigmoid
BT20 omipalisib 0 3 72
 8 2.586
0.00689
-0.587
0.893
0.044
-0.714
0.478
0.958
7.32e-05
NA
0.00572
0.017
0.281
0.00491
0.0669
0.945
0.983
4.7e-06
NA
Hs 578T AS605240 2
sigmoid
sigmoid
Hs578T AS-605240 2
 8 2.547
1.89
0.43
0.194
1.81
0.011
0.541
0.988
1.81e-06
NA
1.6
0.426
0.784
0.971
0.117
0.532
0.983
4.67e-06
NA
HCC70 WYE-125132 1 72
sigmoid
sigmoid
HCC70 WYE-132 0 1 72
 8 1.382
0.0518
0.346
0.418
0.0175
0.348
1.1
0.985
3.58e-06
NA
Inf
0.579
0.727
0.0165
0.579
1.09
0.983
4.63e-06
NA
HCC70 Omipalisib 1 72
sigmoid
sigmoid
HCC70 omipalisib 0 1 72
 8 1.358
0.00496
-0.785
1.14
0.0157
-0.775
0.812
0.989
1.34e-06
NA
0.0123
0.0486
0.349
0.011
0.0462
0.833
0.984
3.73e-06
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
Hs 578T Omipalisib 1
sigmoid
sigmoid
Hs578T omipalisib 1
 8 2.079
0.00552
-0.546
0.842
0.17
-1.0
0.321
0.98
8.1e-06
NA
0.0079
0.0459
0.351
0.0079
0.0
0.369
0.984
4.12e-06
NA
Hs 578T Torin2 2
sigmoid
sigmoid
Hs578T Torin2 2
 8 2.528
0.0153
-0.467
0.778
0.112
-0.771
0.47
0.986
2.55e-06
NA
0.0122
0.0353
0.352
0.0109
0.036
0.668
0.984
4.09e-06
NA
Hs 578T AZD-6482 3
sigmoid
sigmoid
Hs578T AZD6482 3
 8 2.832
6.09
0.667
0.0547
24.1
-1.0
0.799
0.989
1.5e-06
NA
5.12
0.597
0.93
5.12
0.0
0.861
0.985
3.33e-06
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
Hs 578T Dactolisib 2
sigmoid
sigmoid
Hs578T dactolisib 2
 8 2.509
0.0128
-0.0617
0.655
0.0126
0.00741
0.79
0.974
1.78e-05
NA
0.0105
0.15
0.405
0.00638
0.203
1.04
0.985
3.67e-06
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
BT-20 WYE-125132 1 72
sigmoid
sigmoid
BT20 WYE-132 0 1 72
 8 2.067
0.0893
0.289
0.402
0.0435
0.256
1.0
0.987
2.28e-06
NA
0.154
0.403
0.647
0.0353
0.375
0.941
0.985
3.56e-06
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 2 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 2 72
 8 2.794
Inf
0.613
0.036
1.16
0.61
5.0
0.99
1.1e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 3 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 3 72
 8 3.162
Inf
0.654
0.0322
1.18
0.65
4.68
0.99
1.03e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-549 WYE-125132 2 72
sigmoid
sigmoid
BT549 WYE-132 0 2 72
 8 1.780
0.0329
0.0784
0.528
0.0287
0.0811
1.29
0.988
1.59e-06
NA
0.0545
0.333
0.604
0.0236
0.337
1.34
0.986
2.87e-06
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA