Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 MK2206 3 72
sigmoid
sigmoid
HCC1806 MK-2206 0 3 72
 8 3.199
74.1
0.843
0.0434
320.0
-0.491
0.468
0.981
6.96e-06
NA
Inf
0.769
0.934
4.46
0.507
0.566
0.976
1.46e-05
NA
HCC1806 MK2206 1 72
sigmoid
sigmoid
HCC1806 MK-2206 0 1 72
 8 2.746
47.7
0.818
0.0504
320.0
-0.715
0.466
0.981
7.02e-06
NA
Inf
0.769
0.934
4.46
0.507
0.566
0.976
1.46e-05
NA
BT-549 Torin2 3 72
sigmoid
sigmoid
BT549 Torin2 0 3 72
 8 1.613
0.00797
-0.254
0.794
0.0216
-0.338
0.517
0.98
8.52e-06
NA
0.0236
0.204
0.458
0.0104
0.191
0.585
0.976
1.3e-05
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
BT-20 Torin2 3 72
sigmoid
sigmoid
BT20 Torin2 0 3 72
 8 2.458
0.019
-0.64
0.751
0.234
-1.0
0.438
0.959
6.92e-05
NA
0.0147
0.0148
0.379
0.0123
0.0598
0.727
0.977
1.28e-05
NA
HCC70 MK2206 3 72
sigmoid
sigmoid
HCC70 MK-2206 0 3 72
 8 2.378
1.43
0.423
0.139
0.451
0.39
1.31
0.983
5.28e-06
NA
1.47
0.445
0.859
0.349
0.437
1.44
0.977
1.2e-05
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
HCC1806 Omipalisib 3 72
sigmoid
sigmoid
HCC1806 omipalisib 0 3 72
 8 3.217
0.147
-0.221
0.437
0.71
-0.707
0.559
0.981
7.41e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
 8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
HCC1806 Omipalisib 2 72
sigmoid
sigmoid
HCC1806 omipalisib 0 2 72
 8 2.849
0.112
-0.311
0.479
0.543
-0.739
0.573
0.98
8.07e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
HCC38 PIK-93 1 72
sigmoid
sigmoid
HCC38 PIK-93 0 1 72
 8 1.741
5.24
0.61
0.0782
24.5
-1.0
0.713
0.982
6.07e-06
NA
9.93
0.686
0.935
9.93
0.0
0.729
0.979
9.08e-06
NA
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
 8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA
HCC1806 Omipalisib 1 72
sigmoid
sigmoid
HCC1806 omipalisib 0 1 72
 8 2.764
0.104
-0.333
0.49
0.508
-0.746
0.577
0.98
8.23e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
Hs 578T Omipalisib 2
sigmoid
sigmoid
Hs578T omipalisib 2
 8 2.507
0.0155
-0.52
0.766
0.239
-1.0
0.402
0.993
3.45e-07
NA
0.0114
0.028
0.355
0.0114
0.0
0.468
0.981
6.9e-06
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
Hs 578T AS605240 3
sigmoid
sigmoid
Hs578T AS-605240 3
 8 2.856
63.8
0.588
0.0965
0.826
0.494
1.03
0.983
4.89e-06
NA
5.75
0.518
0.879
0.552
0.465
1.14
0.981
6.87e-06
NA
HCC70 AS605240 3 72
sigmoid
sigmoid
HCC70 AS-605240 0 3 72
 8 2.447
Inf
0.58
0.112
0.427
0.549
1.18
0.985
3.24e-06
NA
Inf
0.562
0.877
0.345
0.544
1.24
0.982
6.14e-06
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
HCC38 ZSTK474 2 72
sigmoid
sigmoid
HCC38 ZSTK474 0 2 72
 8 2.253
1.63
0.396
0.196
2.18
-0.0865
0.554
0.984
4.3e-06
NA
2.0
0.445
0.803
1.14
0.135
0.556
0.982
5.91e-06
NA
BT-20 AZD8055 1 72
sigmoid
sigmoid
BT20 AZD8055 0 1 72
 8 2.117
0.0548
0.243
0.465
0.0266
0.213
0.768
0.984
4.08e-06
NA
0.0937
0.365
0.589
0.0198
0.335
0.713
0.982
5.4e-06
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA