Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 TGX221 2 72
flat
flat
BT20 TGX-221 0 2 72
 8 1.656
Inf
1.0
0.0477
0.0
1.0
0.01
-0.101
1.0
0.946
Inf
1.0
0.961
0.0
1.0
0.01
-0.101
1.0
0.956
BT-20 BX-912 2 72
flat
flat
BT20 BX-912 0 2 72
 8 1.873
Inf
0.683
0.213
0.0
0.683
0.01
0.118
0.686
0.777
Inf
0.724
0.81
0.0
0.724
0.01
0.111
0.702
0.802
HCC70 XL147 2 72
flat
flat
HCC70 pilaralisib 0 2 72
 8 1.789
Inf
0.966
0.0311
0.0
0.966
0.01
-0.12
1.0
0.965
Inf
0.97
0.973
0.0
0.97
0.01
-0.121
1.0
0.969
HCC38 Alpelisib 3 72
flat
flat
HCC38 alpelisib 0 3 72
 8 1.398
Inf
0.75
0.0995
0.0
0.75
0.01
0.141
0.634
0.883
Inf
0.829
0.932
0.0
0.829
0.01
0.113
0.698
0.92
Hs 578T Sirolimus 2
flat
flat
Hs578T rapamycin 2
 8 2.536
Inf
0.623
0.341
0.0
0.623
0.01
0.16
0.593
0.66
Inf
0.589
0.623
0.0
0.589
0.01
-0.232
1.0
0.624
HCC38 KIN001-244 3 72
flat
flat
HCC38 KIN001-244 0 3 72
 8 1.472
Inf
0.849
0.0658
0.0
0.849
0.01
0.182
0.548
0.929
Inf
0.891
0.952
0.0
0.891
0.01
0.181
0.549
0.948
Hs 578T XL147 1
flat
flat
Hs578T pilaralisib 1
 8 2.013
Inf
0.967
0.00411
0.0
0.967
0.01
0.193
0.525
0.991
Inf
0.967
0.996
0.0
0.967
0.01
0.196
0.519
0.991
BT-20 CAL-101 2 72
flat
flat
BT20 idelalisib 0 2 72
 8 1.768
Inf
0.818
0.0943
0.0
0.818
0.01
0.226
0.463
0.898
Inf
0.845
0.918
0.0
0.845
0.01
0.222
0.471
0.912
HCC38 AS605240 3 72
flat
flat
HCC38 AS-605240 0 3 72
 8 1.343
Inf
0.958
-0.0162
0.0
0.958
0.01
-0.233
1.0
1.01
Inf
0.972
1.01
0.0
0.972
0.01
-0.235
1.0
1.01
BT-20 BX-912 1 72
flat
flat
BT20 BX-912 0 1 72
 8 2.193
Inf
0.858
0.0928
0.0
0.858
0.01
0.25
0.422
0.903
Inf
0.851
0.901
0.0
0.851
0.01
0.243
0.433
0.897
HCC70 Everolimus 2 72
flat
flat
HCC70 everolimus 0 2 72
 8 1.730
Inf
0.674
0.227
0.0
0.674
0.01
0.271
0.388
0.766
Inf
0.735
0.812
0.0
0.735
0.01
0.264
0.399
0.807
HCC70 XL147 1 72
flat
flat
HCC70 pilaralisib 0 1 72
 8 1.396
Inf
1.05
-0.0406
0.0
1.05
0.01
-0.285
1.0
1.03
Inf
1.04
1.03
0.0
1.04
0.01
-0.295
1.0
1.02
HCC70 XL147 3 72
flat
flat
HCC70 pilaralisib 0 3 72
 8 2.478
Inf
1.03
-0.0199
0.0
1.03
0.01
-0.318
1.0
1.02
Inf
1.03
1.03
0.0
1.03
0.01
-0.331
1.0
1.02
Hs 578T XL147 3
flat
flat
Hs578T pilaralisib 3
 8 2.879
Inf
0.971
-0.00618
0.0
0.971
0.01
0.331
0.299
1.0
Inf
0.959
1.01
0.0
0.959
0.01
0.319
0.315
1.0
HCC1806 Alpelisib 3 72
flat
flat
HCC1806 alpelisib 0 3 72
 8 3.224
Inf
0.93
0.0502
0.0
0.93
0.01
-0.335
1.0
0.948
Inf
0.891
0.921
0.0
0.891
0.01
-0.351
1.0
0.919
HCC1806 Alpelisib 2 72
flat
flat
HCC1806 alpelisib 0 2 72
 8 2.856
Inf
0.921
0.0566
0.0
0.921
0.01
-0.336
1.0
0.941
Inf
0.891
0.921
0.0
0.891
0.01
-0.351
1.0
0.919
HCC1806 Alpelisib 1 72
flat
flat
HCC1806 alpelisib 0 1 72
 8 2.771
Inf
0.918
0.0583
0.0
0.918
0.01
-0.337
1.0
0.94
Inf
0.891
0.921
0.0
0.891
0.01
-0.351
1.0
0.919
BT-549 Sirolimus 3 72
flat
flat
BT549 rapamycin 0 3 72
 8 1.703
Inf
0.455
0.482
0.0
0.455
0.01
0.376
0.243
0.518
Inf
0.582
0.626
0.0
0.582
0.01
0.436
0.179
0.625
HCC70 Alpelisib 3 72
flat
flat
HCC70 alpelisib 0 3 72
 8 2.465
Inf
0.859
0.027
0.0
0.859
0.01
0.407
0.209
0.961
Inf
0.835
0.968
0.0
0.835
0.01
0.394
0.222
0.954
BT-20 XL147 1 72
flat
flat
BT20 pilaralisib 0 1 72
 8 2.128
Inf
0.815
0.048
0.0
0.815
0.01
0.411
0.205
0.939
Inf
0.813
0.95
0.0
0.813
0.01
0.383
0.234
0.937
BT-549 AS605240 2 72
flat
flat
BT549 AS-605240 0 2 72
 8 1.961
Inf
0.91
0.0479
0.0
0.91
0.01
0.414
0.201
0.949
Inf
0.914
0.954
0.0
0.914
0.01
0.418
0.197
0.951
Hs 578T XL147 2
flat
flat
Hs578T pilaralisib 2
 8 2.509
Inf
0.976
0.000255
0.0
0.976
0.01
0.435
0.181
0.997
Inf
0.97
1.0
0.0
0.97
0.01
0.432
0.183
0.996
BT-549 Alpelisib 1 72
flat
flat
BT549 alpelisib 0 1 72
 8 1.822
Inf
0.747
0.0781
0.0
0.747
0.01
0.439
0.176
0.914
Inf
0.782
0.931
0.0
0.782
0.01
0.415
0.2
0.925
Hs 578T Everolimus 3
flat
flat
Hs578T everolimus 3
 8 2.848
Inf
0.664
0.299
0.0
0.664
0.01
0.475
0.144
0.702
Inf
0.592
0.631
0.0
0.592
0.01
0.486
0.136
0.632
BT-20 KIN001-244 3 72
flat
flat
BT20 KIN001-244 0 3 72
 8 2.608
Inf
0.841
0.062
0.0
0.841
0.01
0.489
0.133
0.935
Inf
0.805
0.922
0.0
0.805
0.01
0.475
0.145
0.919