Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 WYE-125132 2 72
sigmoid
sigmoid
BT549 WYE-132 0 2 72
 8 1.780
0.0329
0.0784
0.528
0.0287
0.0811
1.29
0.988
1.59e-06
NA
0.0545
0.333
0.604
0.0236
0.337
1.34
0.986
2.87e-06
NA
HCC70 Omipalisib 1 72
sigmoid
sigmoid
HCC70 omipalisib 0 1 72
 8 1.358
0.00496
-0.785
1.14
0.0157
-0.775
0.812
0.989
1.34e-06
NA
0.0123
0.0486
0.349
0.011
0.0462
0.833
0.984
3.73e-06
NA
BT-549 PIK-93 1 72
sigmoid
sigmoid
BT549 PIK-93 0 1 72
 8 1.777
Inf
0.691
0.0438
1.77
0.561
1.47
0.989
1.31e-06
NA
Inf
0.742
0.963
1.64
0.646
1.47
0.988
1.83e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
 8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
Hs 578T AZD-6482 3
sigmoid
sigmoid
Hs578T AZD6482 3
 8 2.832
6.09
0.667
0.0547
24.1
-1.0
0.799
0.989
1.5e-06
NA
5.12
0.597
0.93
5.12
0.0
0.861
0.985
3.33e-06
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC1806 ZSTK474 3 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 3 72
 8 3.162
Inf
0.654
0.0322
1.18
0.65
4.68
0.99
1.03e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC70 Omipalisib 3 72
sigmoid
sigmoid
HCC70 omipalisib 0 3 72
 8 2.458
0.0158
-0.404
0.771
0.0319
-0.379
0.8
0.99
8.95e-07
NA
0.0148
0.051
0.376
0.0127
0.0733
1.02
0.996
4.59e-08
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC1806 ZSTK474 2 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 2 72
 8 2.794
Inf
0.613
0.036
1.16
0.61
5.0
0.99
1.1e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
BT-549 BX-912 2 72
sigmoid
sigmoid
BT549 BX-912 0 2 72
 8 1.948
1.04
0.33
0.126
0.84
0.329
5.0
0.99
1.01e-06
NA
1.28
0.452
0.892
0.808
0.451
5.0
0.987
2.4e-06
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
HCC70 Omipalisib 2 72
sigmoid
sigmoid
HCC70 omipalisib 0 2 72
 8 1.682
0.00746
-0.705
1.01
0.0241
-0.703
0.749
0.991
6.69e-07
NA
0.0135
0.0399
0.359
0.0121
0.0458
0.852
0.989
1.45e-06
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
 8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA