Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
Hs 578T Torin2 2
sigmoid
sigmoid
Hs578T Torin2 2
 8 2.528
0.0153
-0.467
0.778
0.112
-0.771
0.47
0.986
2.55e-06
NA
0.0122
0.0353
0.352
0.0109
0.036
0.668
0.984
4.09e-06
NA
HCC1806 Dactolisib 3 72
sigmoid
sigmoid
HCC1806 dactolisib 0 3 72
 8 3.196
0.193
0.0324
0.393
0.437
-0.302
0.579
0.986
2.91e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-20 Torin1 2 72
sigmoid
sigmoid
BT20 Torin1 0 2 72
 8 1.793
0.00766
-0.152
0.806
0.00992
-0.146
0.986
0.986
2.59e-06
NA
0.0131
0.215
0.421
0.00727
0.212
0.936
0.988
1.92e-06
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
HCC70 PI103 3 72
sigmoid
sigmoid
HCC70 PI-103 0 3 72
 8 2.446
1.51
0.227
0.0983
1.57
-0.0288
1.54
0.986
2.66e-06
NA
1.48
0.303
0.906
1.15
0.168
1.59
0.976
1.42e-05
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
BT-20 WYE-125132 1 72
sigmoid
sigmoid
BT20 WYE-132 0 1 72
 8 2.067
0.0893
0.289
0.402
0.0435
0.256
1.0
0.987
2.28e-06
NA
0.154
0.403
0.647
0.0353
0.375
0.941
0.985
3.56e-06
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC1806 Torin1 2 72
sigmoid
sigmoid
HCC1806 Torin1 0 2 72
 8 2.840
0.336
0.264
0.309
0.154
0.203
0.668
0.988
1.77e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC1806 Torin1 1 72
sigmoid
sigmoid
HCC1806 Torin1 0 1 72
 8 2.755
0.303
0.246
0.317
0.152
0.185
0.669
0.988
1.74e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
Hs 578T AS605240 2
sigmoid
sigmoid
Hs578T AS-605240 2
 8 2.547
1.89
0.43
0.194
1.81
0.011
0.541
0.988
1.81e-06
NA
1.6
0.426
0.784
0.971
0.117
0.532
0.983
4.67e-06
NA
BT-549 Omipalisib 3 72
sigmoid
sigmoid
BT549 omipalisib 0 3 72
 8 1.777
0.0114
-0.23
0.753
0.0162
-0.178
0.879
0.988
1.64e-06
NA
0.0201
0.183
0.459
0.0112
0.208
0.924
0.991
6.53e-07
NA
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
 8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA
HCC70 Torin2 3 72
sigmoid
sigmoid
HCC70 Torin2 0 3 72
 8 2.425
0.076
-0.384
0.567
0.532
-0.933
0.541
0.988
1.88e-06
NA
0.0694
0.0576
0.51
0.0694
0.0
0.61
0.973
2.02e-05
NA