Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Alpelisib 3 72
flat
flat
HCC1806 alpelisib 0 3 72
 8 3.224
Inf
0.93
0.0502
0.0
0.93
0.01
-0.335
1.0
0.948
Inf
0.891
0.921
0.0
0.891
0.01
-0.351
1.0
0.919
HCC1806 KIN001-244 2 72
flat
flat
HCC1806 KIN001-244 0 2 72
 8 2.827
Inf
0.986
0.0229
0.0
0.986
0.01
-0.0574
1.0
0.98
Inf
0.981
0.968
0.0
0.981
0.01
-0.0553
1.0
0.972
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
HCC38 PI103 1 72
sigmoid
sigmoid
HCC38 PI-103 0 1 72
 8 1.782
0.755
0.222
0.201
0.601
0.12
1.2
0.996
4.45e-08
NA
1.39
0.416
0.839
0.494
0.359
1.23
0.995
1.01e-07
NA
Hs 578T PI103 1
sigmoid
sigmoid
Hs578T PI-103 1
 8 2.062
0.131
-0.0743
0.433
0.182
-0.173
0.898
0.996
4.43e-08
NA
0.175
0.204
0.643
0.117
0.152
0.898
0.995
1.02e-07
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
BT-549 Trametinib 2 72
sigmoid
sigmoid
BT549 trametinib 0 2 72
 8 1.914
Inf
0.602
0.2
0.0685
0.581
0.837
0.995
1.05e-07
NA
Inf
0.654
0.822
0.0601
0.638
0.839
0.995
1.04e-07
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
Hs 578T Torin2 3
sigmoid
sigmoid
Hs578T Torin2 3
 8 2.844
0.0272
-0.327
0.667
0.144
-0.614
0.48
0.994
2.62e-07
NA
0.0164
0.0451
0.381
0.0148
0.0308
0.638
0.995
1.07e-07
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
HCC1806 Torin2 2 72
sigmoid
sigmoid
HCC1806 Torin2 0 2 72
 8 2.843
0.0589
-0.181
0.57
0.0771
-0.211
1.3
0.996
6.72e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.08e-07
NA
HCC1806 Torin2 1 72
sigmoid
sigmoid
HCC1806 Torin2 0 1 72
 8 2.759
0.0569
-0.203
0.582
0.0763
-0.234
1.3
0.996
6.76e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
 8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
BT-20 Torin2 3 72
sigmoid
sigmoid
BT20 Torin2 0 3 72
 8 2.458
0.019
-0.64
0.751
0.234
-1.0
0.438
0.959
6.92e-05
NA
0.0147
0.0148
0.379
0.0123
0.0598
0.727
0.977
1.28e-05
NA
HCC70 MK2206 3 72
sigmoid
sigmoid
HCC70 MK-2206 0 3 72
 8 2.378
1.43
0.423
0.139
0.451
0.39
1.31
0.983
5.28e-06
NA
1.47
0.445
0.859
0.349
0.437
1.44
0.977
1.2e-05
NA