Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
 8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA
HCC38 Dactolisib 3 72
sigmoid
sigmoid
HCC38 dactolisib 0 3 72
 8 1.468
0.0082
-0.197
0.778
0.0127
-0.181
0.711
0.993
3.98e-07
NA
0.0268
0.262
0.497
0.00923
0.277
0.757
0.994
2.62e-07
NA
HCC1806 Trametinib 2 72
sigmoid
sigmoid
HCC1806 trametinib 0 2 72
 8 2.836
Inf
0.8
0.135
0.00973
0.808
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 1 72
sigmoid
sigmoid
HCC1806 trametinib 0 1 72
 8 2.751
Inf
0.795
0.139
0.00972
0.802
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 3 72
sigmoid
sigmoid
HCC1806 trametinib 0 3 72
 8 3.204
Inf
0.822
0.12
0.00981
0.829
0.872
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
HCC70 Dactolisib 3 72
sigmoid
sigmoid
HCC70 dactolisib 0 3 72
 8 2.430
0.738
0.321
0.312
18.6
-0.818
0.3
0.975
1.64e-05
NA
0.688
0.365
0.675
0.635
0.0134
0.338
0.97
2.7e-05
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
HCC1806 BX-912 3 72
sigmoid
sigmoid
HCC1806 BX-912 0 3 72
 8 3.193
1.09
0.234
0.126
0.897
0.217
2.99
0.999
2.85e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 BX-912 2 72
sigmoid
sigmoid
HCC1806 BX-912 0 2 72
 8 2.825
0.992
0.159
0.14
0.888
0.141
2.99
0.999
3.32e-09
NA
0.894
0.214
0.854
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
BT-549 WYE-125132 2 72
sigmoid
sigmoid
BT549 WYE-132 0 2 72
 8 1.780
0.0329
0.0784
0.528
0.0287
0.0811
1.29
0.988
1.59e-06
NA
0.0545
0.333
0.604
0.0236
0.337
1.34
0.986
2.87e-06
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
HCC1806 GDC-0980 2 72
sigmoid
sigmoid
HCC1806 apitolisib 0 2 72
 8 2.781
1.32
0.355
0.148
0.746
0.241
1.15
0.995
1.49e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 1 72
sigmoid
sigmoid
HCC1806 apitolisib 0 1 72
 8 2.696
1.24
0.339
0.152
0.739
0.223
1.15
0.995
1.52e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC70 Torin2 2 72
sigmoid
sigmoid
HCC70 Torin2 0 2 72
 8 1.826
0.0342
-0.522
0.671
0.401
-1.0
0.446
0.979
9.23e-06
NA
0.0639
0.0733
0.507
0.0639
0.0
0.462
0.969
2.98e-05
NA
HCC38 Omipalisib 3 72
sigmoid
sigmoid
HCC38 omipalisib 0 3 72
 8 1.446
0.0145
-0.503
0.802
0.0539
-0.597
0.6
0.993
3.08e-07
NA
0.0449
0.134
0.499
0.0308
0.107
0.644
0.993
2.98e-07
NA
HCC38 MK2206 2 72
sigmoid
sigmoid
HCC38 MK-2206 0 2 72
 8 2.159
Inf
0.788
0.0476
0.776
0.775
1.99
0.972
2.1e-05
NA
Inf
0.785
0.951
0.752
0.772
1.98
0.969
2.9e-05
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA