Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T AZD8055 3
sigmoid
sigmoid
Hs578T AZD8055 3
 8 2.886
0.0538
0.232
0.451
0.0311
0.22
1.06
0.995
1.13e-07
NA
0.039
0.247
0.521
0.0208
0.231
0.989
0.995
1.55e-07
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
HCC1806 ZSTK474 2 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 2 72
 8 2.794
Inf
0.613
0.036
1.16
0.61
5.0
0.99
1.1e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC38 Torin1 2 72
sigmoid
sigmoid
HCC38 Torin1 0 2 72
 8 2.136
0.0241
0.0393
0.573
0.0203
0.0651
0.82
0.995
1.24e-07
NA
0.0309
0.247
0.512
0.013
0.267
0.88
0.996
4.87e-08
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
Hs 578T ZSTK474 2
sigmoid
sigmoid
Hs578T ZSTK474 2
 8 2.554
0.715
0.187
0.263
5.92
-0.896
0.485
0.995
1.27e-07
NA
0.583
0.264
0.722
0.583
0.0
0.56
0.993
3.28e-07
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA
BT-549 PIK-93 1 72
sigmoid
sigmoid
BT549 PIK-93 0 1 72
 8 1.777
Inf
0.691
0.0438
1.77
0.561
1.47
0.989
1.31e-06
NA
Inf
0.742
0.963
1.64
0.646
1.47
0.988
1.83e-06
NA
HCC1806 AZD8055 2 72
sigmoid
sigmoid
HCC1806 AZD8055 0 2 72
 8 2.817
Inf
0.546
0.24
0.0517
0.535
1.19
0.995
1.31e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
BT-549 Buparlisib 2 72
sigmoid
sigmoid
BT549 buparlisib 0 2 72
 8 1.913
0.681
-0.306
0.217
1.08
-0.538
1.59
0.998
1.31e-08
NA
0.821
0.132
0.838
0.769
0.0514
1.66
0.996
8.95e-08
NA
HCC70 AZD8055 1 72
sigmoid
sigmoid
HCC70 AZD8055 0 1 72
 8 1.339
0.0485
0.242
0.442
0.0243
0.26
1.06
0.976
1.32e-05
NA
Inf
0.529
0.721
0.0222
0.54
1.08
0.974
1.81e-05
NA
Hs 578T Trametinib 2
sigmoid
sigmoid
Hs578T trametinib 2
 8 2.483
0.00633
0.074
0.701
0.00558
0.0362
0.593
0.998
1.32e-08
NA
0.0058
0.214
0.361
0.00257
0.193
0.602
0.998
3.66e-09
NA
HCC38 Pictilisib 3 72
sigmoid
sigmoid
HCC38 pictilisib 0 3 72
 8 1.420
3.12
0.499
0.129
2.45
0.0818
0.738
0.976
1.33e-05
NA
20.5
0.664
0.911
2.24
0.401
0.731
0.974
1.7e-05
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 Omipalisib 1 72
sigmoid
sigmoid
HCC70 omipalisib 0 1 72
 8 1.358
0.00496
-0.785
1.14
0.0157
-0.775
0.812
0.989
1.34e-06
NA
0.0123
0.0486
0.349
0.011
0.0462
0.833
0.984
3.73e-06
NA
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
HCC1806 AZD8055 3 72
sigmoid
sigmoid
HCC1806 AZD8055 0 3 72
 8 3.185
Inf
0.593
0.215
0.0523
0.583
1.19
0.995
1.36e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
 8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA