Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 AS605240 1 72
sigmoid
sigmoid
HCC38 AS-605240 0 1 72
 8 1.744
Inf
0.734
0.0803
0.448
0.691
0.881
0.969
2.92e-05
NA
Inf
0.78
0.932
0.405
0.748
0.895
0.967
3.48e-05
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
BT-549 AZD-6482 3 72
sigmoid
sigmoid
BT549 AZD6482 0 3 72
 8 1.744
8.87
0.616
0.0979
2.2
0.324
0.749
0.993
2.93e-07
NA
115.0
0.69
0.918
1.91
0.476
0.744
0.993
4.19e-07
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
BT-549 PI103 1 72
sigmoid
sigmoid
BT549 PI-103 0 1 72
 8 1.795
0.206
0.0898
0.34
0.185
0.0628
1.25
0.997
2.96e-08
NA
0.348
0.336
0.737
0.155
0.318
1.25
0.996
8.76e-08
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
BT-549 GDC-0980 2 72
sigmoid
sigmoid
BT549 apitolisib 0 2 72
 8 1.939
0.189
0.0264
0.357
0.193
-0.011
1.04
0.997
2.98e-08
NA
0.278
0.274
0.71
0.142
0.257
1.07
0.997
3.64e-08
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
HCC38 Omipalisib 3 72
sigmoid
sigmoid
HCC38 omipalisib 0 3 72
 8 1.446
0.0145
-0.503
0.802
0.0539
-0.597
0.6
0.993
3.08e-07
NA
0.0449
0.134
0.499
0.0308
0.107
0.644
0.993
2.98e-07
NA
HCC38 AZD8055 2 72
sigmoid
sigmoid
HCC38 AZD8055 0 2 72
 8 2.128
0.0616
0.16
0.467
0.045
0.124
0.912
0.993
3.13e-07
NA
0.0875
0.314
0.594
0.0332
0.284
0.869
0.991
6.5e-07
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 AS605240 3 72
sigmoid
sigmoid
HCC70 AS-605240 0 3 72
 8 2.447
Inf
0.58
0.112
0.427
0.549
1.18
0.985
3.24e-06
NA
Inf
0.562
0.877
0.345
0.544
1.24
0.982
6.14e-06
NA
HCC1806 BX-912 2 72
sigmoid
sigmoid
HCC1806 BX-912 0 2 72
 8 2.825
0.992
0.159
0.14
0.888
0.141
2.99
0.999
3.32e-09
NA
0.894
0.214
0.854
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
BT-549 Dactolisib 2 72
sigmoid
sigmoid
BT549 dactolisib 0 2 72
 8 1.889
0.00968
-0.00862
0.677
0.00884
0.0542
1.27
0.985
3.3e-06
NA
0.0134
0.266
0.48
0.00701
0.305
1.45
0.988
1.53e-06
NA
HCC38 WYE-125132 1 72
sigmoid
sigmoid
HCC38 WYE-132 0 1 72
 8 1.708
0.0604
0.142
0.447
0.0481
0.134
1.36
0.997
3.43e-08
NA
0.115
0.384
0.669
0.0413
0.381
1.4
0.996
6.46e-08
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
Hs 578T Omipalisib 2
sigmoid
sigmoid
Hs578T omipalisib 2
 8 2.507
0.0155
-0.52
0.766
0.239
-1.0
0.402
0.993
3.45e-07
NA
0.0114
0.028
0.355
0.0114
0.0
0.468
0.981
6.9e-06
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 WYE-125132 3 72
sigmoid
sigmoid
HCC1806 WYE-132 0 3 72
 8 3.242
Inf
0.531
0.255
0.0458
0.517
0.885
0.997
3.48e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
Hs 578T AZD8055 2
sigmoid
sigmoid
Hs578T AZD8055 2
 8 2.480
0.0521
0.149
0.469
0.0387
0.142
1.13
0.999
3.49e-10
NA
0.0495
0.253
0.557
0.0273
0.249
1.16
0.999
4.45e-10
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA