Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
Hs 578T Torin2 2
sigmoid
sigmoid
Hs578T Torin2 2
 8 2.528
0.0153
-0.467
0.778
0.112
-0.771
0.47
0.986
2.55e-06
NA
0.0122
0.0353
0.352
0.0109
0.036
0.668
0.984
4.09e-06
NA
BT-549 PI103 2 72
sigmoid
sigmoid
BT549 PI-103 0 2 72
 8 1.893
0.218
0.0201
0.344
0.229
-0.0262
1.08
0.997
2.55e-08
NA
0.326
0.28
0.725
0.169
0.261
1.13
0.996
6.2e-08
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
BT-20 Torin1 2 72
sigmoid
sigmoid
BT20 Torin1 0 2 72
 8 1.793
0.00766
-0.152
0.806
0.00992
-0.146
0.986
0.986
2.59e-06
NA
0.0131
0.215
0.421
0.00727
0.212
0.936
0.988
1.92e-06
NA
HCC70 PI103 2 72
sigmoid
sigmoid
HCC70 PI-103 0 2 72
 8 1.739
1.19
0.0238
0.151
2.67
-0.766
1.15
0.997
2.59e-08
NA
1.68
0.312
0.885
1.68
0.0
1.21
0.996
6.86e-08
NA
HCC38 Omipalisib 1 72
sigmoid
sigmoid
HCC38 omipalisib 0 1 72
 8 1.760
0.0231
-0.316
0.672
0.152
-0.638
0.438
0.97
2.61e-05
NA
0.0585
0.151
0.512
0.0499
0.0356
0.465
0.956
8.65e-05
NA
Hs 578T Torin2 3
sigmoid
sigmoid
Hs578T Torin2 3
 8 2.844
0.0272
-0.327
0.667
0.144
-0.614
0.48
0.994
2.62e-07
NA
0.0164
0.0451
0.381
0.0148
0.0308
0.638
0.995
1.07e-07
NA
HCC70 PI103 3 72
sigmoid
sigmoid
HCC70 PI-103 0 3 72
 8 2.446
1.51
0.227
0.0983
1.57
-0.0288
1.54
0.986
2.66e-06
NA
1.48
0.303
0.906
1.15
0.168
1.59
0.976
1.42e-05
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
HCC1806 Trametinib 2 72
sigmoid
sigmoid
HCC1806 trametinib 0 2 72
 8 2.836
Inf
0.8
0.135
0.00973
0.808
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 3 72
sigmoid
sigmoid
HCC1806 trametinib 0 3 72
 8 3.204
Inf
0.822
0.12
0.00981
0.829
0.872
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 1 72
sigmoid
sigmoid
HCC1806 trametinib 0 1 72
 8 2.751
Inf
0.795
0.139
0.00972
0.802
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC70 Torin1 3 72
sigmoid
sigmoid
HCC70 Torin1 0 3 72
 8 2.415
3.74
0.495
0.279
0.0352
0.496
1.02
0.994
2.6e-07
NA
5.73
0.495
0.709
0.0284
0.498
1.06
0.994
2.26e-07
NA
BT-20 GDC-0980 1 72
sigmoid
sigmoid
BT20 apitolisib 0 1 72
 8 2.001
0.0935
-0.289
0.498
0.128
-0.251
1.29
0.994
2.71e-07
NA
0.113
0.126
0.62
0.0885
0.151
1.48
0.996
7.34e-08
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-20 Omipalisib 1 72
sigmoid
sigmoid
BT20 omipalisib 0 1 72
 8 2.078
0.00617
-0.729
0.985
0.0283
-0.739
0.596
0.97
2.83e-05
NA
0.00781
0.0157
0.306
0.00685
0.0597
0.96
0.988
1.57e-06
NA
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
HCC1806 BX-912 3 72
sigmoid
sigmoid
HCC1806 BX-912 0 3 72
 8 3.193
1.09
0.234
0.126
0.897
0.217
2.99
0.999
2.85e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
BT-549 BX-912 3 72
sigmoid
sigmoid
BT549 BX-912 0 3 72
 8 1.728
1.0
0.335
0.109
0.758
0.332
3.91
0.993
2.87e-07
NA
2.46
0.497
0.916
0.73
0.496
3.92
0.992
6.03e-07
NA
HCC1806 Dactolisib 3 72
sigmoid
sigmoid
HCC1806 dactolisib 0 3 72
 8 3.196
0.193
0.0324
0.393
0.437
-0.302
0.579
0.986
2.91e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA