Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
HCC38 MK2206 2 72
sigmoid
sigmoid
HCC38 MK-2206 0 2 72
 8 2.159
Inf
0.788
0.0476
0.776
0.775
1.99
0.972
2.1e-05
NA
Inf
0.785
0.951
0.752
0.772
1.98
0.969
2.9e-05
NA
BT-549 AZD8055 2 72
sigmoid
sigmoid
BT549 AZD8055 0 2 72
 8 1.848
0.0373
0.14
0.506
0.0287
0.138
1.23
0.994
2.1e-07
NA
0.0653
0.354
0.605
0.0239
0.35
1.2
0.995
1.39e-07
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
 8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
BT-20 WYE-125132 1 72
sigmoid
sigmoid
BT20 WYE-132 0 1 72
 8 2.067
0.0893
0.289
0.402
0.0435
0.256
1.0
0.987
2.28e-06
NA
0.154
0.403
0.647
0.0353
0.375
0.941
0.985
3.56e-06
NA
HCC70 Torin1 2 72
sigmoid
sigmoid
HCC70 Torin1 0 2 72
 8 1.726
0.107
0.323
0.391
0.0276
0.322
0.762
0.997
2.34e-08
NA
3.98
0.49
0.694
0.0225
0.491
0.775
0.997
1.93e-08
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
BT-549 Dactolisib 3 72
sigmoid
sigmoid
BT549 dactolisib 0 3 72
 8 1.801
0.0058
-0.00929
0.751
0.00579
0.000747
0.866
0.994
2.41e-07
NA
0.011
0.282
0.442
0.00425
0.29
0.909
0.995
1.54e-07
NA
HCC70 TGX221 3 72
sigmoid
sigmoid
HCC70 TGX-221 0 3 72
 8 2.459
Inf
0.7
0.0886
0.338
0.675
1.11
0.971
2.48e-05
NA
Inf
0.671
0.9
0.295
0.648
1.13
0.966
3.94e-05
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
BT-549 GDC-0980 3 72
sigmoid
sigmoid
BT549 apitolisib 0 3 72
 8 1.802
0.162
0.0283
0.377
0.158
0.0179
1.2
0.994
2.53e-07
NA
0.268
0.302
0.709
0.128
0.294
1.2
0.992
4.85e-07
NA
HCC70 BX-912 2 72
sigmoid
sigmoid
HCC70 BX-912 0 2 72
 8 1.693
1.25
0.00257
0.0619
1.25
-0.00649
5.0
0.971
2.55e-05
NA
1.44
0.311
0.961
1.2
0.306
5.0
0.956
8.35e-05
NA