Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
HCC70 CAL-101 3 72
sigmoid
sigmoid
HCC70 idelalisib 0 3 72
 8 2.510
Inf
0.724
0.0241
1.39
0.69
2.52
0.964
4.57e-05
NA
Inf
0.689
0.973
1.33
0.655
2.52
0.956
8.64e-05
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 AS605240 2 72
sigmoid
sigmoid
HCC1806 AS-605240 0 2 72
 8 2.813
Inf
0.913
0.0124
0.569
0.913
2.8
0.936
0.000261
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 AS605240 1 72
sigmoid
sigmoid
HCC1806 AS-605240 0 1 72
 8 2.728
Inf
0.911
0.0128
0.569
0.91
2.8
0.936
0.000262
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 AS605240 3 72
sigmoid
sigmoid
HCC1806 AS-605240 0 3 72
 8 3.181
Inf
0.923
0.011
0.57
0.923
2.81
0.936
0.000257
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 BX-912 3 72
sigmoid
sigmoid
HCC1806 BX-912 0 3 72
 8 3.193
1.09
0.234
0.126
0.897
0.217
2.99
0.999
2.85e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 BX-912 2 72
sigmoid
sigmoid
HCC1806 BX-912 0 2 72
 8 2.825
0.992
0.159
0.14
0.888
0.141
2.99
0.999
3.32e-09
NA
0.894
0.214
0.854
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC70 CAL-101 2 72
sigmoid
sigmoid
HCC70 idelalisib 0 2 72
 8 1.738
Inf
0.62
0.0432
0.959
0.611
3.13
0.965
4.31e-05
NA
Inf
0.693
0.965
0.935
0.686
3.13
0.96
6.52e-05
NA
BT-549 BX-912 1 72
sigmoid
sigmoid
BT549 BX-912 0 1 72
 8 1.839
0.909
0.247
0.157
0.742
0.24
3.23
0.992
5.95e-07
NA
1.2
0.419
0.872
0.698
0.415
3.25
0.988
1.54e-06
NA
HCC38 CAL-101 2 72
sigmoid
sigmoid
HCC38 idelalisib 0 2 72
 8 2.154
Inf
0.881
0.0205
0.901
0.879
3.37
0.892
0.00125
NA
Inf
0.876
0.979
0.891
0.874
3.37
0.887
0.00144
NA
BT-549 MK2206 3 72
sigmoid
sigmoid
BT549 MK-2206 0 3 72
 8 1.685
Inf
0.714
0.131
0.123
0.711
3.44
0.953
0.000102
NA
Inf
0.771
0.895
0.123
0.768
3.25
0.949
0.000136
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
BT-549 BX-912 3 72
sigmoid
sigmoid
BT549 BX-912 0 3 72
 8 1.728
1.0
0.335
0.109
0.758
0.332
3.91
0.993
2.87e-07
NA
2.46
0.497
0.916
0.73
0.496
3.92
0.992
6.03e-07
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
HCC1806 ZSTK474 3 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 3 72
 8 3.162
Inf
0.654
0.0322
1.18
0.65
4.68
0.99
1.03e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
BT-20 Omipalisib 2 72
sigmoid
sigmoid
BT20 omipalisib 0 2 72
 8 1.717
0.00324
-0.799
1.1
0.00361
-0.354
4.99
0.808
0.00704
NA
0.00518
0.0194
0.291
0.00429
0.111
1.34
0.968
3.16e-05
NA
HCC38 AZD-6482 3 72
sigmoid
sigmoid
HCC38 AZD6482 0 3 72
 8 1.420
Inf
0.821
0.0615
0.324
0.826
5.0
0.849
0.00342
NA
Inf
0.875
0.957
0.323
0.879
5.0
0.846
0.00367
NA
HCC38 XL147 3 72
sigmoid
sigmoid
HCC38 pilaralisib 0 3 72
 8 1.420
Inf
0.909
0.0219
0.114
0.921
5.0
0.815
0.00631
NA
Inf
0.936
0.985
0.114
0.945
5.0
0.813
0.00654
NA