Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
Hs 578T KIN001-244 2
sigmoid
sigmoid
Hs578T KIN001-244 2
 8 2.505
Inf
0.819
0.0357
4.8
0.531
1.14
0.891
0.0013
NA
44.3
0.788
0.957
4.79
0.457
1.1
0.878
0.0018
NA
BT-549 Torin1 2 72
sigmoid
sigmoid
BT549 Torin1 0 2 72
 8 1.881
0.0165
0.0298
0.618
0.0147
0.0572
1.03
0.993
4.2e-07
NA
0.0262
0.287
0.52
0.0111
0.306
1.1
0.99
9.68e-07
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
 8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
BT-549 AZD8055 1 72
sigmoid
sigmoid
BT549 AZD8055 0 1 72
 8 1.781
0.0305
0.165
0.526
0.0228
0.14
1.13
0.992
4.7e-07
NA
0.0615
0.382
0.599
0.0189
0.367
1.12
0.994
1.9e-07
NA
BT-549 PI103 2 72
sigmoid
sigmoid
BT549 PI-103 0 2 72
 8 1.893
0.218
0.0201
0.344
0.229
-0.0262
1.08
0.997
2.55e-08
NA
0.326
0.28
0.725
0.169
0.261
1.13
0.996
6.2e-08
NA
HCC70 TGX221 3 72
sigmoid
sigmoid
HCC70 TGX-221 0 3 72
 8 2.459
Inf
0.7
0.0886
0.338
0.675
1.11
0.971
2.48e-05
NA
Inf
0.671
0.9
0.295
0.648
1.13
0.966
3.94e-05
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
BT-20 Alpelisib 1 72
sigmoid
sigmoid
BT20 alpelisib 0 1 72
 8 2.077
1.14
0.046
0.196
3.52
-1.0
0.977
0.966
4.1e-05
NA
1.32
0.26
0.825
1.32
0.0
1.13
0.942
0.000194
NA
BT-549 WYE-125132 3 72
sigmoid
sigmoid
BT549 WYE-132 0 3 72
 8 1.662
0.0271
0.0265
0.567
0.0245
0.0525
1.1
0.992
5.72e-07
NA
0.0574
0.33
0.592
0.0203
0.345
1.13
0.991
6.54e-07
NA
Hs 578T AS605240 3
sigmoid
sigmoid
Hs578T AS-605240 3
 8 2.856
63.8
0.588
0.0965
0.826
0.494
1.03
0.983
4.89e-06
NA
5.75
0.518
0.879
0.552
0.465
1.14
0.981
6.87e-06
NA
HCC1806 AZD8055 3 72
sigmoid
sigmoid
HCC1806 AZD8055 0 3 72
 8 3.185
Inf
0.593
0.215
0.0523
0.583
1.19
0.995
1.36e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
HCC1806 AZD8055 1 72
sigmoid
sigmoid
HCC1806 AZD8055 0 1 72
 8 2.732
Inf
0.534
0.247
0.0515
0.522
1.19
0.995
1.3e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
HCC1806 AZD8055 2 72
sigmoid
sigmoid
HCC1806 AZD8055 0 2 72
 8 2.817
Inf
0.546
0.24
0.0517
0.535
1.19
0.995
1.31e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
Hs 578T AZD8055 2
sigmoid
sigmoid
Hs578T AZD8055 2
 8 2.480
0.0521
0.149
0.469
0.0387
0.142
1.13
0.999
3.49e-10
NA
0.0495
0.253
0.557
0.0273
0.249
1.16
0.999
4.45e-10
NA
HCC1806 Torin2 1 72
sigmoid
sigmoid
HCC1806 Torin2 0 1 72
 8 2.759
0.0569
-0.203
0.582
0.0763
-0.234
1.3
0.996
6.76e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC1806 Torin2 2 72
sigmoid
sigmoid
HCC1806 Torin2 0 2 72
 8 2.843
0.0589
-0.181
0.57
0.0771
-0.211
1.3
0.996
6.72e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.08e-07
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC70 WYE-125132 2 72
sigmoid
sigmoid
HCC70 WYE-132 0 2 72
 8 1.675
0.213
0.471
0.332
0.0211
0.467
1.18
0.996
6.89e-08
NA
Inf
0.598
0.744
0.0194
0.595
1.17
0.996
7.52e-08
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
HCC70 AZD8055 3 72
sigmoid
sigmoid
HCC70 AZD8055 0 3 72
 8 2.442
Inf
0.571
0.287
0.0133
0.574
1.17
0.98
8.55e-06
NA
Inf
0.554
0.694
0.0116
0.556
1.17
0.974
1.69e-05
NA
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
 8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA