Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
Hs 578T Torin1 1
sigmoid
sigmoid
Hs578T Torin1 1
 8 1.956
0.0217
0.0183
0.598
0.0203
0.0286
0.911
0.994
1.81e-07
NA
0.0321
0.267
0.524
0.0141
0.28
0.995
0.996
8.78e-08
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
HCC70 Omipalisib 3 72
sigmoid
sigmoid
HCC70 omipalisib 0 3 72
 8 2.458
0.0158
-0.404
0.771
0.0319
-0.379
0.8
0.99
8.95e-07
NA
0.0148
0.051
0.376
0.0127
0.0733
1.02
0.996
4.59e-08
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
HCC38 AZD8055 3 72
sigmoid
sigmoid
HCC38 AZD8055 0 3 72
 8 1.417
0.0464
0.0327
0.53
0.0463
0.000983
1.04
0.997
4.27e-08
NA
0.157
0.392
0.658
0.041
0.372
1.02
0.996
5.78e-08
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC38 AZD-6482 1 72
sigmoid
sigmoid
HCC38 AZD6482 0 1 72
 8 1.732
Inf
0.862
0.0239
1.4
0.804
1.03
0.909
0.000761
NA
Inf
0.883
0.98
1.34
0.837
1.03
0.904
0.000873
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA
Hs 578T Dactolisib 2
sigmoid
sigmoid
Hs578T dactolisib 2
 8 2.509
0.0128
-0.0617
0.655
0.0126
0.00741
0.79
0.974
1.78e-05
NA
0.0105
0.15
0.405
0.00638
0.203
1.04
0.985
3.67e-06
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
BT-549 WYE-125132 1 72
sigmoid
sigmoid
BT549 WYE-132 0 1 72
 8 1.787
0.0317
0.11
0.542
0.026
0.0962
1.09
0.996
5.11e-08
NA
0.062
0.349
0.589
0.0213
0.338
1.05
0.997
3.82e-08
NA
BT-549 Torin1 3 72
sigmoid
sigmoid
BT549 Torin1 0 3 72
 8 1.757
0.0123
0.026
0.659
0.0112
0.0466
1.02
0.997
3.77e-08
NA
0.0235
0.309
0.513
0.00878
0.322
1.05
0.997
1.65e-08
NA
Hs 578T Dactolisib 3
sigmoid
sigmoid
Hs578T dactolisib 3
 8 2.837
0.0118
0.0569
0.624
0.00848
0.115
0.799
0.96
6.53e-05
NA
0.00728
0.164
0.377
0.0043
0.212
1.05
0.968
3.34e-05
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
HCC70 Torin1 3 72
sigmoid
sigmoid
HCC70 Torin1 0 3 72
 8 2.415
3.74
0.495
0.279
0.0352
0.496
1.02
0.994
2.6e-07
NA
5.73
0.495
0.709
0.0284
0.498
1.06
0.994
2.26e-07
NA
BT-549 GDC-0980 2 72
sigmoid
sigmoid
BT549 apitolisib 0 2 72
 8 1.939
0.189
0.0264
0.357
0.193
-0.011
1.04
0.997
2.98e-08
NA
0.278
0.274
0.71
0.142
0.257
1.07
0.997
3.64e-08
NA
HCC70 AZD8055 1 72
sigmoid
sigmoid
HCC70 AZD8055 0 1 72
 8 1.339
0.0485
0.242
0.442
0.0243
0.26
1.06
0.976
1.32e-05
NA
Inf
0.529
0.721
0.0222
0.54
1.08
0.974
1.81e-05
NA
HCC70 WYE-125132 1 72
sigmoid
sigmoid
HCC70 WYE-132 0 1 72
 8 1.382
0.0518
0.346
0.418
0.0175
0.348
1.1
0.985
3.58e-06
NA
Inf
0.579
0.727
0.0165
0.579
1.09
0.983
4.63e-06
NA
Hs 578T GDC-0980 3
sigmoid
sigmoid
Hs578T apitolisib 3
 8 2.831
0.243
0.145
0.315
0.19
0.112
1.02
0.998
4.02e-09
NA
0.179
0.206
0.665
0.114
0.196
1.09
0.999
9.76e-10
NA