Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC1806 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 1 72 | 8 | 2.782 | 11.7 | 0.79 | 0.049 | 43.7 | -1.0 | 0.831 | 0.811 | 0.00677 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
HCC70 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 2 72 | 8 | 1.682 | 0.00746 | -0.705 | 1.01 | 0.0241 | -0.703 | 0.749 | 0.991 | 6.69e-07 | NA | 0.0135 | 0.0399 | 0.359 | 0.0121 | 0.0458 | 0.852 | 0.989 | 1.45e-06 | NA |
Hs 578T | Alpelisib | 3 | sigmoid | sigmoid | Hs578T alpelisib 3 | 8 | 2.856 | Inf | 0.712 | 0.0759 | 0.872 | 0.616 | 0.828 | 0.963 | 5.21e-05 | NA | Inf | 0.641 | 0.901 | 0.65 | 0.553 | 0.853 | 0.955 | 8.85e-05 | NA | |
HCC70 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 1 72 | 8 | 1.345 | 0.0472 | 0.15 | 0.487 | 0.0311 | 0.149 | 0.849 | 0.973 | 1.89e-05 | NA | 0.93 | 0.475 | 0.693 | 0.0276 | 0.475 | 0.854 | 0.973 | 2.05e-05 | NA |
BT-549 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 3 72 | 8 | 1.757 | 0.0178 | 0.159 | 0.59 | 0.0122 | 0.145 | 0.913 | 0.942 | 0.000193 | NA | 0.0479 | 0.383 | 0.555 | 0.00973 | 0.372 | 0.854 | 0.954 | 9.74e-05 | NA |
HCC1806 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 2 72 | 8 | 2.874 | 0.872 | 0.479 | 0.284 | 0.045 | 0.464 | 0.883 | 0.997 | 3.66e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 1 72 | 8 | 2.790 | 0.603 | 0.466 | 0.292 | 0.0448 | 0.45 | 0.883 | 0.997 | 3.72e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 3 72 | 8 | 3.242 | Inf | 0.531 | 0.255 | 0.0458 | 0.517 | 0.885 | 0.997 | 3.48e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
Hs 578T | AZD-6482 | 3 | sigmoid | sigmoid | Hs578T AZD6482 3 | 8 | 2.832 | 6.09 | 0.667 | 0.0547 | 24.1 | -1.0 | 0.799 | 0.989 | 1.5e-06 | NA | 5.12 | 0.597 | 0.93 | 5.12 | 0.0 | 0.861 | 0.985 | 3.33e-06 | NA | |
Hs 578T | TGX221 | 3 | sigmoid | sigmoid | Hs578T TGX-221 3 | 8 | 2.818 | 24.2 | 0.885 | 0.0148 | 88.9 | -1.0 | 0.843 | 0.958 | 7.66e-05 | NA | 23.4 | 0.846 | 0.98 | 23.4 | 0.0 | 0.862 | 0.953 | 0.000103 | NA | |
BT-20 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 1 72 | 8 | 2.085 | 1.25 | 0.163 | 0.177 | 5.0 | -1.0 | 0.791 | 0.994 | 1.75e-07 | NA | 1.52 | 0.323 | 0.838 | 1.52 | 0.0 | 0.865 | 0.989 | 1.22e-06 | NA |
HCC38 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 1 72 | 8 | 1.742 | 2.47 | 0.456 | 0.132 | 1.34 | 0.202 | 0.843 | 0.991 | 7.12e-07 | NA | 9.02 | 0.575 | 0.893 | 1.0 | 0.426 | 0.869 | 0.99 | 1.01e-06 | NA |
HCC38 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 2 72 | 8 | 2.128 | 0.0616 | 0.16 | 0.467 | 0.045 | 0.124 | 0.912 | 0.993 | 3.13e-07 | NA | 0.0875 | 0.314 | 0.594 | 0.0332 | 0.284 | 0.869 | 0.991 | 6.5e-07 | NA |
HCC38 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 2 72 | 8 | 2.143 | 0.0568 | 0.149 | 0.473 | 0.0413 | 0.124 | 0.896 | 0.998 | 9.66e-09 | NA | 0.078 | 0.305 | 0.587 | 0.0297 | 0.285 | 0.875 | 0.997 | 1.58e-08 | NA |
HCC70 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 1 72 | 8 | 1.421 | 0.015 | 0.339 | 0.521 | 0.00411 | 0.34 | 0.879 | 0.966 | 4.1e-05 | NA | Inf | 0.566 | 0.653 | 0.00373 | 0.566 | 0.875 | 0.968 | 3.23e-05 | NA |
HCC38 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 2 72 | 8 | 2.136 | 0.0241 | 0.0393 | 0.573 | 0.0203 | 0.0651 | 0.82 | 0.995 | 1.24e-07 | NA | 0.0309 | 0.247 | 0.512 | 0.013 | 0.267 | 0.88 | 0.996 | 4.87e-08 | NA |
HCC1806 | Trametinib | 2 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 2 72 | 8 | 2.836 | Inf | 0.8 | 0.135 | 0.00973 | 0.808 | 0.873 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC1806 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 3 72 | 8 | 3.204 | Inf | 0.822 | 0.12 | 0.00981 | 0.829 | 0.872 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC1806 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 1 72 | 8 | 2.751 | Inf | 0.795 | 0.139 | 0.00972 | 0.802 | 0.873 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC38 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC38 AS-605240 0 1 72 | 8 | 1.744 | Inf | 0.734 | 0.0803 | 0.448 | 0.691 | 0.881 | 0.969 | 2.92e-05 | NA | Inf | 0.78 | 0.932 | 0.405 | 0.748 | 0.895 | 0.967 | 3.48e-05 | NA |
Hs 578T | ZSTK474 | 3 | sigmoid | sigmoid | Hs578T ZSTK474 3 | 8 | 2.863 | 0.913 | 0.31 | 0.201 | 0.613 | 0.143 | 0.846 | 0.999 | 6.21e-10 | NA | 0.607 | 0.298 | 0.767 | 0.329 | 0.211 | 0.895 | 0.999 | 1.43e-09 | NA | |
Hs 578T | PI103 | 1 | sigmoid | sigmoid | Hs578T PI-103 1 | 8 | 2.062 | 0.131 | -0.0743 | 0.433 | 0.182 | -0.173 | 0.898 | 0.996 | 4.43e-08 | NA | 0.175 | 0.204 | 0.643 | 0.117 | 0.152 | 0.898 | 0.995 | 1.02e-07 | NA | |
BT-20 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 3 72 | 8 | 2.566 | 0.839 | 0.172 | 0.22 | 0.914 | -0.0483 | 1.09 | 0.954 | 9.59e-05 | NA | 0.843 | 0.254 | 0.768 | 0.809 | 0.0179 | 0.898 | 0.918 | 0.000551 | NA |
HCC38 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 1 72 | 8 | 1.688 | 0.0287 | -0.0113 | 0.569 | 0.0278 | 0.013 | 0.843 | 0.993 | 4.14e-07 | NA | 0.0653 | 0.304 | 0.585 | 0.0204 | 0.325 | 0.9 | 0.992 | 4.53e-07 | NA |
HCC70 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 2 72 | 8 | 1.724 | 0.17 | 0.404 | 0.346 | 0.0331 | 0.385 | 0.897 | 0.996 | 7.36e-08 | NA | Inf | 0.543 | 0.728 | 0.0284 | 0.531 | 0.905 | 0.996 | 6.22e-08 | NA |