Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	KIN001-244	3	72	flat	flat	HCC70 KIN001-244 0 3 72	8	2.472	Inf	0.916	0.0295	0.0	0.916	0.01	-0.0208	1.0	0.969	Inf	0.899	0.965	0.0	0.899	0.01	-0.00883	1.0	0.963
HCC38	KIN001-244	2	72	flat	flat	HCC38 KIN001-244 0 2 72	8	2.210	Inf	0.948	0.0304	0.0	0.948	0.01	-0.0213	1.0	0.969	Inf	0.944	0.967	0.0	0.944	0.01	-0.0218	1.0	0.966
Hs 578T	TGX221	2		sigmoid	sigmoid	Hs578T TGX-221 2	8	2.462	Inf	0.816	0.0307	0.904	0.781	1.29	0.964	4.56e-05	NA	Inf	0.789	0.964	0.834	0.754	1.3	0.96	6.63e-05	NA
HCC70	XL147	2	72	flat	flat	HCC70 pilaralisib 0 2 72	8	1.789	Inf	0.966	0.0311	0.0	0.966	0.01	-0.12	1.0	0.965	Inf	0.97	0.973	0.0	0.97	0.01	-0.121	1.0	0.969
HCC1806	ZSTK474	3	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 3 72	8	3.162	Inf	0.654	0.0322	1.18	0.65	4.68	0.99	1.03e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
HCC1806	PIK-93	3	72	sigmoid	sigmoid	HCC1806 PIK-93 0 3 72	8	3.206	56.0	0.873	0.0337	320.0	-0.872	0.579	0.859	0.00279	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
HCC38	AZD-6482	2	72	sigmoid	sigmoid	HCC38 AZD6482 0 2 72	8	2.132	Inf	0.898	0.0351	4.71	0.773	0.497	0.824	0.0055	NA	Inf	0.894	0.963	4.7	0.765	0.492	0.82	0.00588	NA
BT-549	XL147	3	72	flat	flat	BT549 pilaralisib 0 3 72	8	1.772	Inf	0.933	0.0351	0.0	0.933	0.01	-0.0699	1.0	0.962	Inf	0.941	0.969	0.0	0.941	0.01	-0.0712	1.0	0.967
Hs 578T	KIN001-244	2		sigmoid	sigmoid	Hs578T KIN001-244 2	8	2.505	Inf	0.819	0.0357	4.8	0.531	1.14	0.891	0.0013	NA	44.3	0.788	0.957	4.79	0.457	1.1	0.878	0.0018	NA
HCC1806	ZSTK474	2	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 2 72	8	2.794	Inf	0.613	0.036	1.16	0.61	5.0	0.99	1.1e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
HCC1806	ZSTK474	1	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 1 72	8	2.709	Inf	0.602	0.037	1.17	0.599	4.88	0.99	1.12e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
HCC38	KIN001-244	1	72	sigmoid	sigmoid	HCC38 KIN001-244 0 1 72	8	1.751	Inf	0.894	0.0375	4.46	0.77	0.479	0.71	0.0244	NA	Inf	0.909	0.968	4.5	0.802	0.474	0.705	0.0256	NA
HCC1806	PIK-93	2	72	sigmoid	sigmoid	HCC1806 PIK-93 0 2 72	8	2.838	41.1	0.857	0.038	265.0	-1.0	0.59	0.858	0.00286	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
BT-549	XL147	1	72	flat	flat	BT549 pilaralisib 0 1 72	8	1.855	Inf	0.941	0.0385	0.0	0.941	0.01	-0.0931	1.0	0.954	Inf	0.946	0.965	0.0	0.946	0.01	-0.0808	1.0	0.958
Hs 578T	KIN001-244	1		sigmoid	sigmoid	Hs578T KIN001-244 1	8	2.041	24.7	0.739	0.0391	4.05	0.414	0.972	0.968	3.4e-05	NA	Inf	0.752	0.962	3.15	0.51	0.99	0.964	4.65e-05	NA
HCC1806	PIK-93	1	72	sigmoid	sigmoid	HCC1806 PIK-93 0 1 72	8	2.753	44.0	0.853	0.0391	304.0	-1.0	0.568	0.858	0.00285	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
BT-20	KIN001-244	1	72	flat	flat	BT20 KIN001-244 0 1 72	8	2.125	Inf	0.911	0.0401	0.0	0.911	0.01	-0.00641	1.0	0.957	Inf	0.908	0.958	0.0	0.908	0.01	-0.00745	1.0	0.955
HCC70	XL147	1	72	flat	flat	HCC70 pilaralisib 0 1 72	8	1.396	Inf	1.05	-0.0406	0.0	1.05	0.01	-0.285	1.0	1.03	Inf	1.04	1.03	0.0	1.04	0.01	-0.295	1.0	1.02
BT-549	Alpelisib	2	72	sigmoid	sigmoid	BT549 alpelisib 0 2 72	8	1.927	Inf	0.832	0.0409	4.24	0.663	0.548	0.706	0.0254	NA	Inf	0.844	0.962	4.26	0.686	0.542	0.696	0.0282	NA
BT-549	CAL-101	1	72	sigmoid	sigmoid	BT549 idelalisib 0 1 72	8	1.791	Inf	0.836	0.041	4.8	0.605	0.778	0.924	0.00044	NA	Inf	0.858	0.964	4.79	0.659	0.767	0.92	0.000518	NA
HCC1806	Pictilisib	3	72	sigmoid	sigmoid	HCC1806 pictilisib 0 3 72	8	3.234	14.1	0.818	0.0423	52.2	-0.98	0.831	0.814	0.00649	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
HCC70	CAL-101	2	72	sigmoid	sigmoid	HCC70 idelalisib 0 2 72	8	1.738	Inf	0.62	0.0432	0.959	0.611	3.13	0.965	4.31e-05	NA	Inf	0.693	0.965	0.935	0.686	3.13	0.96	6.52e-05	NA
HCC1806	MK2206	3	72	sigmoid	sigmoid	HCC1806 MK-2206 0 3 72	8	3.199	74.1	0.843	0.0434	320.0	-0.491	0.468	0.981	6.96e-06	NA	Inf	0.769	0.934	4.46	0.507	0.566	0.976	1.46e-05	NA
BT-549	AS605240	1	72	sigmoid	sigmoid	BT549 AS-605240 0 1 72	8	1.804	Inf	0.893	0.0436	4.49	0.778	0.375	0.862	0.00261	NA	Inf	0.905	0.961	4.52	0.804	0.371	0.861	0.00267	NA
BT-549	PIK-93	1	72	sigmoid	sigmoid	BT549 PIK-93 0 1 72	8	1.777	Inf	0.691	0.0438	1.77	0.561	1.47	0.989	1.31e-06	NA	Inf	0.742	0.963	1.64	0.646	1.47	0.988	1.83e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)