Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | Dactolisib | 1 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 1 72 | 8 | 1.840 | 0.00961 | -0.00769 | 0.683 | 0.00888 | 0.0384 | 1.01 | 0.985 | 3.53e-06 | NA | 0.0161 | 0.275 | 0.482 | 0.0068 | 0.303 | 1.09 | 0.987 | 2.38e-06 | NA |
Hs 578T | Dactolisib | 1 | sigmoid | sigmoid | Hs578T dactolisib 1 | 8 | 2.047 | 0.00952 | -0.0606 | 0.691 | 0.00928 | 0.0117 | 0.91 | 0.977 | 1.27e-05 | NA | 0.0124 | 0.213 | 0.443 | 0.00621 | 0.259 | 1.06 | 0.985 | 3.61e-06 | NA | |
BT-549 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 1 72 | 8 | 1.789 | 0.0164 | -0.2 | 0.693 | 0.0219 | -0.149 | 0.887 | 0.986 | 2.66e-06 | NA | 0.0272 | 0.194 | 0.495 | 0.0148 | 0.228 | 0.993 | 0.991 | 8.42e-07 | NA |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
BT-20 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT20 Torin2 0 3 72 | 8 | 2.458 | 0.019 | -0.64 | 0.751 | 0.234 | -1.0 | 0.438 | 0.959 | 6.92e-05 | NA | 0.0147 | 0.0148 | 0.379 | 0.0123 | 0.0598 | 0.727 | 0.977 | 1.28e-05 | NA |
BT-549 | Omipalisib | 2 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 2 72 | 8 | 1.990 | 0.0104 | -0.291 | 0.751 | 0.026 | -0.32 | 0.542 | 0.966 | 4.09e-05 | NA | 0.0175 | 0.127 | 0.422 | 0.011 | 0.118 | 0.58 | 0.953 | 0.000102 | NA |
BT-549 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 3 72 | 8 | 1.801 | 0.0058 | -0.00929 | 0.751 | 0.00579 | 0.000747 | 0.866 | 0.994 | 2.41e-07 | NA | 0.011 | 0.282 | 0.442 | 0.00425 | 0.29 | 0.909 | 0.995 | 1.54e-07 | NA |
BT-549 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 3 72 | 8 | 1.777 | 0.0114 | -0.23 | 0.753 | 0.0162 | -0.178 | 0.879 | 0.988 | 1.64e-06 | NA | 0.0201 | 0.183 | 0.459 | 0.0112 | 0.208 | 0.924 | 0.991 | 6.53e-07 | NA |
HCC38 | Torin2 | 1 | 72 | sigmoid | sigmoid | HCC38 Torin2 0 1 72 | 8 | 1.778 | 0.0133 | -0.318 | 0.753 | 0.0337 | -0.369 | 0.594 | 0.994 | 1.98e-07 | NA | 0.0264 | 0.148 | 0.459 | 0.0158 | 0.145 | 0.664 | 0.994 | 1.7e-07 | NA |
BT-549 | Torin2 | 1 | 72 | sigmoid | sigmoid | BT549 Torin2 0 1 72 | 8 | 1.771 | 0.0095 | -0.218 | 0.756 | 0.0155 | -0.193 | 0.672 | 0.985 | 3.06e-06 | NA | 0.0183 | 0.19 | 0.452 | 0.00874 | 0.218 | 0.775 | 0.988 | 1.88e-06 | NA |
Hs 578T | Torin2 | 1 | sigmoid | sigmoid | Hs578T Torin2 1 | 8 | 2.031 | 0.015 | -0.405 | 0.761 | 0.0631 | -0.56 | 0.522 | 0.992 | 5.31e-07 | NA | 0.021 | 0.0851 | 0.419 | 0.0163 | 0.0756 | 0.64 | 0.993 | 3.63e-07 | NA | |
Hs 578T | Trametinib | 1 | sigmoid | sigmoid | Hs578T trametinib 1 | 8 | 2.044 | 0.00353 | -0.00904 | 0.765 | 0.00516 | -0.0906 | 0.437 | 0.992 | 4.85e-07 | NA | 0.00661 | 0.238 | 0.385 | 0.00213 | 0.201 | 0.456 | 0.993 | 3e-07 | NA | |
Hs 578T | Omipalisib | 2 | sigmoid | sigmoid | Hs578T omipalisib 2 | 8 | 2.507 | 0.0155 | -0.52 | 0.766 | 0.239 | -1.0 | 0.402 | 0.993 | 3.45e-07 | NA | 0.0114 | 0.028 | 0.355 | 0.0114 | 0.0 | 0.468 | 0.981 | 6.9e-06 | NA | |
BT-549 | Torin2 | 2 | 72 | sigmoid | sigmoid | BT549 Torin2 0 2 72 | 8 | 1.824 | 0.00997 | -0.281 | 0.767 | 0.0212 | -0.282 | 0.594 | 0.975 | 1.47e-05 | NA | 0.0177 | 0.155 | 0.438 | 0.00929 | 0.188 | 0.734 | 0.973 | 2.02e-05 | NA |
HCC70 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 3 72 | 8 | 2.458 | 0.0158 | -0.404 | 0.771 | 0.0319 | -0.379 | 0.8 | 0.99 | 8.95e-07 | NA | 0.0148 | 0.051 | 0.376 | 0.0127 | 0.0733 | 1.02 | 0.996 | 4.59e-08 | NA |
HCC70 | Torin2 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin2 0 1 72 | 8 | 1.364 | 0.0288 | -0.732 | 0.772 | 0.183 | -1.0 | 0.594 | 0.991 | 6.58e-07 | NA | 0.088 | 0.0644 | 0.539 | 0.088 | 0.0 | 0.622 | 0.988 | 1.95e-06 | NA |
HCC38 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 3 72 | 8 | 1.468 | 0.0082 | -0.197 | 0.778 | 0.0127 | -0.181 | 0.711 | 0.993 | 3.98e-07 | NA | 0.0268 | 0.262 | 0.497 | 0.00923 | 0.277 | 0.757 | 0.994 | 2.62e-07 | NA |
Hs 578T | Torin2 | 2 | sigmoid | sigmoid | Hs578T Torin2 2 | 8 | 2.528 | 0.0153 | -0.467 | 0.778 | 0.112 | -0.771 | 0.47 | 0.986 | 2.55e-06 | NA | 0.0122 | 0.0353 | 0.352 | 0.0109 | 0.036 | 0.668 | 0.984 | 4.09e-06 | NA | |
HCC38 | Torin2 | 2 | 72 | sigmoid | sigmoid | HCC38 Torin2 0 2 72 | 8 | 2.140 | 0.0146 | -0.48 | 0.793 | 0.0654 | -0.634 | 0.545 | 0.993 | 3.78e-07 | NA | 0.0176 | 0.056 | 0.391 | 0.015 | 0.0502 | 0.68 | 0.989 | 1.33e-06 | NA |
BT-549 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT549 Torin2 0 3 72 | 8 | 1.613 | 0.00797 | -0.254 | 0.794 | 0.0216 | -0.338 | 0.517 | 0.98 | 8.52e-06 | NA | 0.0236 | 0.204 | 0.458 | 0.0104 | 0.191 | 0.585 | 0.976 | 1.3e-05 | NA |
HCC38 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC38 omipalisib 0 3 72 | 8 | 1.446 | 0.0145 | -0.503 | 0.802 | 0.0539 | -0.597 | 0.6 | 0.993 | 3.08e-07 | NA | 0.0449 | 0.134 | 0.499 | 0.0308 | 0.107 | 0.644 | 0.993 | 2.98e-07 | NA |
BT-20 | Torin2 | 1 | 72 | sigmoid | sigmoid | BT20 Torin2 0 1 72 | 8 | 2.018 | 0.0185 | -0.739 | 0.803 | 0.158 | -1.0 | 0.511 | 0.986 | 2.9e-06 | NA | 0.0245 | 0.0164 | 0.415 | 0.0245 | 0.0 | 0.616 | 0.99 | 1.06e-06 | NA |
BT-20 | Torin1 | 2 | 72 | sigmoid | sigmoid | BT20 Torin1 0 2 72 | 8 | 1.793 | 0.00766 | -0.152 | 0.806 | 0.00992 | -0.146 | 0.986 | 0.986 | 2.59e-06 | NA | 0.0131 | 0.215 | 0.421 | 0.00727 | 0.212 | 0.936 | 0.988 | 1.92e-06 | NA |
Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
HCC38 | Torin2 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin2 0 3 72 | 8 | 1.385 | 0.013 | -0.624 | 0.855 | 0.0547 | -0.706 | 0.615 | 0.996 | 8.13e-08 | NA | 0.0407 | 0.0986 | 0.484 | 0.0311 | 0.0829 | 0.669 | 0.997 | 3.31e-08 | NA |