Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
HCC70 Torin1 3 72
sigmoid
sigmoid
HCC70 Torin1 0 3 72
 8 2.415
3.74
0.495
0.279
0.0352
0.496
1.02
0.994
2.6e-07
NA
5.73
0.495
0.709
0.0284
0.498
1.06
0.994
2.26e-07
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
HCC1806 WYE-125132 2 72
sigmoid
sigmoid
HCC1806 WYE-132 0 2 72
 8 2.874
0.872
0.479
0.284
0.045
0.464
0.883
0.997
3.66e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
HCC70 AZD8055 3 72
sigmoid
sigmoid
HCC70 AZD8055 0 3 72
 8 2.442
Inf
0.571
0.287
0.0133
0.574
1.17
0.98
8.55e-06
NA
Inf
0.554
0.694
0.0116
0.556
1.17
0.974
1.69e-05
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC1806 WYE-125132 1 72
sigmoid
sigmoid
HCC1806 WYE-132 0 1 72
 8 2.790
0.603
0.466
0.292
0.0448
0.45
0.883
0.997
3.72e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
Hs 578T Everolimus 3
flat
flat
Hs578T everolimus 3
 8 2.848
Inf
0.664
0.299
0.0
0.664
0.01
0.475
0.144
0.702
Inf
0.592
0.631
0.0
0.592
0.01
0.486
0.136
0.632
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
 8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
HCC1806 Torin1 2 72
sigmoid
sigmoid
HCC1806 Torin1 0 2 72
 8 2.840
0.336
0.264
0.309
0.154
0.203
0.668
0.988
1.77e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA