Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 Trametinib 3 72
sigmoid
sigmoid
BT549 trametinib 0 3 72
 8 1.755
Inf
0.553
0.223
0.107
0.505
0.899
0.942
0.000194
NA
Inf
0.642
0.817
0.104
0.595
0.804
0.938
0.000236
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
 8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC70 Everolimus 2 72
flat
flat
HCC70 everolimus 0 2 72
 8 1.730
Inf
0.674
0.227
0.0
0.674
0.01
0.271
0.388
0.766
Inf
0.735
0.812
0.0
0.735
0.01
0.264
0.399
0.807
HCC70 Sirolimus 3 72
sigmoid
sigmoid
HCC70 rapamycin 0 3 72
 8 2.548
310.0
0.732
0.227
0.000433
0.63
0.1
0.676
0.034
NA
22876.0
0.693
0.736
0.000237
0.58
0.1
0.659
0.0397
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
HCC70 TGX221 2 72
sigmoid
sigmoid
HCC70 TGX-221 0 2 72
 8 1.786
1.77
0.467
0.233
0.531
0.227
0.503
0.948
0.000139
NA
5.85
0.575
0.806
3.44
0.0897
0.372
0.937
0.000249
NA
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
HCC1806 AZD8055 2 72
sigmoid
sigmoid
HCC1806 AZD8055 0 2 72
 8 2.817
Inf
0.546
0.24
0.0517
0.535
1.19
0.995
1.31e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA
HCC70 WYE-125132 3 72
sigmoid
sigmoid
HCC70 WYE-132 0 3 72
 8 2.417
Inf
0.592
0.246
0.0209
0.606
1.64
0.995
1.48e-07
NA
Inf
0.576
0.739
0.019
0.588
1.64
0.996
7.52e-08
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA
HCC1806 AZD8055 1 72
sigmoid
sigmoid
HCC1806 AZD8055 0 1 72
 8 2.732
Inf
0.534
0.247
0.0515
0.522
1.19
0.995
1.3e-07
NA
0.521
0.484
0.716
0.0427
0.471
1.15
0.996
7.15e-08
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
HCC1806 WYE-125132 3 72
sigmoid
sigmoid
HCC1806 WYE-132 0 3 72
 8 3.242
Inf
0.531
0.255
0.0458
0.517
0.885
0.997
3.48e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA
HCC70 Sirolimus 2 72
flat
flat
HCC70 rapamycin 0 2 72
 8 1.762
Inf
0.685
0.257
0.0
0.685
0.01
0.531
0.103
0.741
Inf
0.739
0.785
0.0
0.739
0.01
0.524
0.108
0.783
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
Hs 578T ZSTK474 2
sigmoid
sigmoid
Hs578T ZSTK474 2
 8 2.554
0.715
0.187
0.263
5.92
-0.896
0.485
0.995
1.27e-07
NA
0.583
0.264
0.722
0.583
0.0
0.56
0.993
3.28e-07
NA