Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Trametinib	3	72	sigmoid	sigmoid	BT20 trametinib 0 3 72	8	2.539	Inf	0.64	0.208	0.104	0.541	0.392	0.967	3.69e-05	NA	Inf	0.604	0.761	0.0656	0.513	0.391	0.964	4.56e-05	NA
BT-20	Trametinib	2	72	sigmoid	sigmoid	BT20 trametinib 0 2 72	8	1.723	0.761	0.303	0.289	11.1	-0.768	0.347	0.965	4.13e-05	NA	2.56	0.478	0.77	2.56	0.0	0.362	0.957	8.16e-05	NA
BT-20	GDC-0980	1	72	sigmoid	sigmoid	BT20 apitolisib 0 1 72	8	2.001	0.0935	-0.289	0.498	0.128	-0.251	1.29	0.994	2.71e-07	NA	0.113	0.126	0.62	0.0885	0.151	1.48	0.996	7.34e-08	NA
BT-20	Trametinib	1	72	sigmoid	sigmoid	BT20 trametinib 0 1 72	8	2.016	14.3	0.54	0.225	0.135	0.458	0.534	0.989	1.3e-06	NA	Inf	0.59	0.791	0.0955	0.534	0.545	0.989	1.43e-06	NA
BT-20	Torin2	3	72	sigmoid	sigmoid	BT20 Torin2 0 3 72	8	2.458	0.019	-0.64	0.751	0.234	-1.0	0.438	0.959	6.92e-05	NA	0.0147	0.0148	0.379	0.0123	0.0598	0.727	0.977	1.28e-05	NA
BT-20	Pictilisib	3	72	sigmoid	sigmoid	BT20 pictilisib 0 3 72	8	2.566	0.839	0.172	0.22	0.914	-0.0483	1.09	0.954	9.59e-05	NA	0.843	0.254	0.768	0.809	0.0179	0.898	0.918	0.000551	NA
BT-20	Buparlisib	3	72	sigmoid	sigmoid	BT20 buparlisib 0 3 72	8	2.529	0.629	-0.303	0.26	1.06	-0.565	1.46	0.994	2.13e-07	NA	0.603	0.0696	0.764	0.603	0.0	1.52	0.984	4.36e-06	NA
BT-20	Torin2	2	72	sigmoid	sigmoid	BT20 Torin2 0 2 72	8	1.733	0.00315	-0.761	0.992	0.0484	-0.95	0.389	0.949	0.000131	NA	0.00804	0.0252	0.336	0.00642	0.0613	0.583	0.974	1.77e-05	NA
BT-20	Torin2	1	72	sigmoid	sigmoid	BT20 Torin2 0 1 72	8	2.018	0.0185	-0.739	0.803	0.158	-1.0	0.511	0.986	2.9e-06	NA	0.0245	0.0164	0.415	0.0245	0.0	0.616	0.99	1.06e-06	NA
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
BT-20	Torin1	3	72	sigmoid	sigmoid	BT20 Torin1 0 3 72	8	2.569	0.0237	0.0343	0.572	0.0199	0.0736	0.899	0.993	2.77e-07	NA	0.0208	0.184	0.46	0.0119	0.204	0.944	0.997	2.51e-08	NA
BT-20	Torin1	2	72	sigmoid	sigmoid	BT20 Torin1 0 2 72	8	1.793	0.00766	-0.152	0.806	0.00992	-0.146	0.986	0.986	2.59e-06	NA	0.0131	0.215	0.421	0.00727	0.212	0.936	0.988	1.92e-06	NA
BT-20	Pictilisib	1	72	sigmoid	sigmoid	BT20 pictilisib 0 1 72	8	2.085	1.25	0.163	0.177	5.0	-1.0	0.791	0.994	1.75e-07	NA	1.52	0.323	0.838	1.52	0.0	0.865	0.989	1.22e-06	NA
BT-20	Buparlisib	2	72	sigmoid	sigmoid	BT20 buparlisib 0 2 72	8	1.743	0.334	-0.45	0.391	0.844	-0.82	1.05	0.972	2.21e-05	NA	0.487	0.105	0.718	0.487	0.0	1.12	0.948	0.000142	NA
BT-20	AZD8055	1	72	sigmoid	sigmoid	BT20 AZD8055 0 1 72	8	2.117	0.0548	0.243	0.465	0.0266	0.213	0.768	0.984	4.08e-06	NA	0.0937	0.365	0.589	0.0198	0.335	0.713	0.982	5.4e-06	NA
BT-20	Torin1	1	72	sigmoid	sigmoid	BT20 Torin1 0 1 72	8	2.022	0.0383	-0.105	0.566	0.0658	-0.179	0.565	0.991	7.45e-07	NA	0.0591	0.197	0.536	0.0286	0.182	0.624	0.994	2.54e-07	NA
BT-20	Buparlisib	1	72	sigmoid	sigmoid	BT20 buparlisib 0 1 72	8	2.131	0.598	-0.394	0.285	1.19	-0.763	1.35	0.992	4.68e-07	NA	0.663	0.0784	0.766	0.663	0.0	1.49	0.981	7.06e-06	NA
BT-549	Pictilisib	1	72	sigmoid	sigmoid	BT549 pictilisib 0 1 72	8	1.772	2.08	0.415	0.117	1.42	0.154	0.959	0.987	2.26e-06	NA	5.12	0.541	0.904	1.06	0.396	0.995	0.985	3.49e-06	NA
BT-549	Everolimus	3	72	sigmoid	flat	BT549 everolimus 0 3 72	8	1.587	59.5	0.533	0.425	1e-05	0.395	0.1	0.702	0.0264	NA	Inf	0.656	0.685	0.0	0.656	0.01	0.48	0.141	0.685
BT-549	Everolimus	1	72	sigmoid	sigmoid	BT549 everolimus 0 1 72	8	1.772	5.64	0.503	0.444	1e-05	0.367	0.1	0.911	0.000706	NA	437200.0	0.603	0.641	0.000146	0.444	0.1	0.858	0.00286	NA
BT-549	CAL-101	3	72	sigmoid	sigmoid	BT549 idelalisib 0 3 72	8	1.770	43.0	0.79	0.0687	320.0	-0.664	0.421	0.862	0.00261	NA	118.0	0.822	0.941	118.0	0.0	0.425	0.854	0.00309	NA
BT-20	PIK-93	3	72	sigmoid	sigmoid	BT20 PIK-93 0 3 72	8	2.532	2.65	0.419	0.097	7.54	-1.0	1.05	0.982	5.47e-06	NA	2.5	0.42	0.892	2.5	0.0	1.17	0.971	2.45e-05	NA
BT-20	Dactolisib	3	72	sigmoid	sigmoid	BT20 dactolisib 0 3 72	8	2.420	0.0111	0.024	0.639	0.00921	0.0987	1.17	0.982	6.27e-06	NA	0.0106	0.198	0.427	0.00645	0.241	1.32	0.99	9.14e-07	NA
BT-20	AZD-6482	3	72	sigmoid	sigmoid	BT20 AZD6482 0 3 72	8	2.601	1.68	0.3	0.173	8.38	-1.0	0.685	0.959	6.72e-05	NA	1.5	0.326	0.805	1.5	0.0	0.733	0.925	0.000414	NA
BT-20	AS605240	3	72	sigmoid	sigmoid	BT20 AS-605240 0 3 72	8	2.607	Inf	0.845	0.0823	4.13	0.662	0.292	0.729	0.0199	NA	Inf	0.81	0.897	3.97	0.589	0.284	0.712	0.0239	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)