Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC38 | Alpelisib | 1 | 72 | flat | flat | HCC38 alpelisib 0 1 72 | 8 | 1.738 | Inf | 0.757 | 0.0835 | 0.0 | 0.757 | 0.01 | 0.593 | 0.0674 | 0.909 | Inf | 0.798 | 0.929 | 0.0 | 0.798 | 0.01 | 0.579 | 0.0744 | 0.923 |
BT-549 | Alpelisib | 1 | 72 | flat | flat | BT549 alpelisib 0 1 72 | 8 | 1.822 | Inf | 0.747 | 0.0781 | 0.0 | 0.747 | 0.01 | 0.439 | 0.176 | 0.914 | Inf | 0.782 | 0.931 | 0.0 | 0.782 | 0.01 | 0.415 | 0.2 | 0.925 |
BT-549 | Alpelisib | 3 | 72 | flat | flat | BT549 alpelisib 0 3 72 | 8 | 1.743 | Inf | 0.817 | 0.068 | 0.0 | 0.817 | 0.01 | -0.0192 | 1.0 | 0.915 | Inf | 0.846 | 0.942 | 0.0 | 0.846 | 0.01 | -0.0162 | 1.0 | 0.928 |
BT-20 | BX-912 | 3 | 72 | flat | flat | BT20 BX-912 0 3 72 | 8 | 2.619 | Inf | 0.904 | 0.0795 | 0.0 | 0.904 | 0.01 | 0.000173 | 0.999 | 0.918 | Inf | 0.879 | 0.9 | 0.0 | 0.879 | 0.01 | 0.00619 | 0.982 | 0.896 |
HCC38 | KIN001-244 | 3 | 72 | flat | flat | HCC38 KIN001-244 0 3 72 | 8 | 1.472 | Inf | 0.849 | 0.0658 | 0.0 | 0.849 | 0.01 | 0.182 | 0.548 | 0.929 | Inf | 0.891 | 0.952 | 0.0 | 0.891 | 0.01 | 0.181 | 0.549 | 0.948 |
HCC38 | Alpelisib | 2 | 72 | flat | flat | HCC38 alpelisib 0 2 72 | 8 | 2.086 | Inf | 0.848 | 0.0559 | 0.0 | 0.848 | 0.01 | -0.0371 | 1.0 | 0.931 | Inf | 0.848 | 0.944 | 0.0 | 0.848 | 0.01 | -0.0359 | 1.0 | 0.932 |
BT-20 | KIN001-244 | 3 | 72 | flat | flat | BT20 KIN001-244 0 3 72 | 8 | 2.608 | Inf | 0.841 | 0.062 | 0.0 | 0.841 | 0.01 | 0.489 | 0.133 | 0.935 | Inf | 0.805 | 0.922 | 0.0 | 0.805 | 0.01 | 0.475 | 0.145 | 0.919 |
BT-20 | CAL-101 | 1 | 72 | flat | flat | BT20 idelalisib 0 1 72 | 8 | 2.112 | Inf | 0.869 | 0.0546 | 0.0 | 0.869 | 0.01 | 0.0807 | 0.777 | 0.938 | Inf | 0.867 | 0.943 | 0.0 | 0.867 | 0.01 | 0.0778 | 0.784 | 0.936 |
BT-20 | XL147 | 1 | 72 | flat | flat | BT20 pilaralisib 0 1 72 | 8 | 2.128 | Inf | 0.815 | 0.048 | 0.0 | 0.815 | 0.01 | 0.411 | 0.205 | 0.939 | Inf | 0.813 | 0.95 | 0.0 | 0.813 | 0.01 | 0.383 | 0.234 | 0.937 |
HCC1806 | Alpelisib | 1 | 72 | flat | flat | HCC1806 alpelisib 0 1 72 | 8 | 2.771 | Inf | 0.918 | 0.0583 | 0.0 | 0.918 | 0.01 | -0.337 | 1.0 | 0.94 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
HCC1806 | Alpelisib | 2 | 72 | flat | flat | HCC1806 alpelisib 0 2 72 | 8 | 2.856 | Inf | 0.921 | 0.0566 | 0.0 | 0.921 | 0.01 | -0.336 | 1.0 | 0.941 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
BT-20 | CAL-101 | 3 | 72 | flat | flat | BT20 idelalisib 0 3 72 | 8 | 2.589 | Inf | 0.916 | 0.0535 | 0.0 | 0.916 | 0.01 | 0.0547 | 0.845 | 0.944 | Inf | 0.894 | 0.932 | 0.0 | 0.894 | 0.01 | 0.0506 | 0.856 | 0.929 |
BT-20 | TGX221 | 2 | 72 | flat | flat | BT20 TGX-221 0 2 72 | 8 | 1.656 | Inf | 1.0 | 0.0477 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.946 | Inf | 1.0 | 0.961 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.956 |
HCC1806 | Alpelisib | 3 | 72 | flat | flat | HCC1806 alpelisib 0 3 72 | 8 | 3.224 | Inf | 0.93 | 0.0502 | 0.0 | 0.93 | 0.01 | -0.335 | 1.0 | 0.948 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
BT-549 | AS605240 | 2 | 72 | flat | flat | BT549 AS-605240 0 2 72 | 8 | 1.961 | Inf | 0.91 | 0.0479 | 0.0 | 0.91 | 0.01 | 0.414 | 0.201 | 0.949 | Inf | 0.914 | 0.954 | 0.0 | 0.914 | 0.01 | 0.418 | 0.197 | 0.951 |
BT-549 | XL147 | 1 | 72 | flat | flat | BT549 pilaralisib 0 1 72 | 8 | 1.855 | Inf | 0.941 | 0.0385 | 0.0 | 0.941 | 0.01 | -0.0931 | 1.0 | 0.954 | Inf | 0.946 | 0.965 | 0.0 | 0.946 | 0.01 | -0.0808 | 1.0 | 0.958 |
BT-20 | KIN001-244 | 1 | 72 | flat | flat | BT20 KIN001-244 0 1 72 | 8 | 2.125 | Inf | 0.911 | 0.0401 | 0.0 | 0.911 | 0.01 | -0.00641 | 1.0 | 0.957 | Inf | 0.908 | 0.958 | 0.0 | 0.908 | 0.01 | -0.00745 | 1.0 | 0.955 |
HCC70 | Alpelisib | 3 | 72 | flat | flat | HCC70 alpelisib 0 3 72 | 8 | 2.465 | Inf | 0.859 | 0.027 | 0.0 | 0.859 | 0.01 | 0.407 | 0.209 | 0.961 | Inf | 0.835 | 0.968 | 0.0 | 0.835 | 0.01 | 0.394 | 0.222 | 0.954 |
BT-549 | XL147 | 3 | 72 | flat | flat | BT549 pilaralisib 0 3 72 | 8 | 1.772 | Inf | 0.933 | 0.0351 | 0.0 | 0.933 | 0.01 | -0.0699 | 1.0 | 0.962 | Inf | 0.941 | 0.969 | 0.0 | 0.941 | 0.01 | -0.0712 | 1.0 | 0.967 |
HCC70 | XL147 | 2 | 72 | flat | flat | HCC70 pilaralisib 0 2 72 | 8 | 1.789 | Inf | 0.966 | 0.0311 | 0.0 | 0.966 | 0.01 | -0.12 | 1.0 | 0.965 | Inf | 0.97 | 0.973 | 0.0 | 0.97 | 0.01 | -0.121 | 1.0 | 0.969 |
HCC38 | XL147 | 2 | 72 | flat | flat | HCC38 pilaralisib 0 2 72 | 8 | 2.194 | Inf | 0.938 | 0.0288 | 0.0 | 0.938 | 0.01 | -0.0925 | 1.0 | 0.968 | Inf | 0.933 | 0.969 | 0.0 | 0.933 | 0.01 | -0.0418 | 1.0 | 0.965 |
HCC70 | KIN001-244 | 3 | 72 | flat | flat | HCC70 KIN001-244 0 3 72 | 8 | 2.472 | Inf | 0.916 | 0.0295 | 0.0 | 0.916 | 0.01 | -0.0208 | 1.0 | 0.969 | Inf | 0.899 | 0.965 | 0.0 | 0.899 | 0.01 | -0.00883 | 1.0 | 0.963 |
HCC38 | KIN001-244 | 2 | 72 | flat | flat | HCC38 KIN001-244 0 2 72 | 8 | 2.210 | Inf | 0.948 | 0.0304 | 0.0 | 0.948 | 0.01 | -0.0213 | 1.0 | 0.969 | Inf | 0.944 | 0.967 | 0.0 | 0.944 | 0.01 | -0.0218 | 1.0 | 0.966 |
HCC38 | XL147 | 1 | 72 | flat | flat | HCC38 pilaralisib 0 1 72 | 8 | 1.752 | Inf | 0.949 | 0.0257 | 0.0 | 0.949 | 0.01 | -0.0703 | 1.0 | 0.973 | Inf | 0.955 | 0.978 | 0.0 | 0.955 | 0.01 | -0.0701 | 1.0 | 0.977 |
HCC1806 | KIN001-244 | 1 | 72 | flat | flat | HCC1806 KIN001-244 0 1 72 | 8 | 2.742 | Inf | 0.986 | 0.0236 | 0.0 | 0.986 | 0.01 | -0.0573 | 1.0 | 0.979 | Inf | 0.981 | 0.968 | 0.0 | 0.981 | 0.01 | -0.0553 | 1.0 | 0.972 |