Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | AZD8055 | 3 | sigmoid | sigmoid | Hs578T AZD8055 3 | 8 | 2.886 | 0.0538 | 0.232 | 0.451 | 0.0311 | 0.22 | 1.06 | 0.995 | 1.13e-07 | NA | 0.039 | 0.247 | 0.521 | 0.0208 | 0.231 | 0.989 | 0.995 | 1.55e-07 | NA | |
Hs 578T | Dactolisib | 1 | sigmoid | sigmoid | Hs578T dactolisib 1 | 8 | 2.047 | 0.00952 | -0.0606 | 0.691 | 0.00928 | 0.0117 | 0.91 | 0.977 | 1.27e-05 | NA | 0.0124 | 0.213 | 0.443 | 0.00621 | 0.259 | 1.06 | 0.985 | 3.61e-06 | NA | |
Hs 578T | Dactolisib | 2 | sigmoid | sigmoid | Hs578T dactolisib 2 | 8 | 2.509 | 0.0128 | -0.0617 | 0.655 | 0.0126 | 0.00741 | 0.79 | 0.974 | 1.78e-05 | NA | 0.0105 | 0.15 | 0.405 | 0.00638 | 0.203 | 1.04 | 0.985 | 3.67e-06 | NA | |
Hs 578T | Dactolisib | 3 | sigmoid | sigmoid | Hs578T dactolisib 3 | 8 | 2.837 | 0.0118 | 0.0569 | 0.624 | 0.00848 | 0.115 | 0.799 | 0.96 | 6.53e-05 | NA | 0.00728 | 0.164 | 0.377 | 0.0043 | 0.212 | 1.05 | 0.968 | 3.34e-05 | NA | |
Hs 578T | Buparlisib | 1 | sigmoid | sigmoid | Hs578T buparlisib 1 | 8 | 2.064 | 0.55 | -0.579 | 0.308 | 1.29 | -1.0 | 1.29 | 0.992 | 4.22e-07 | NA | 0.587 | 0.0401 | 0.759 | 0.587 | 0.0 | 1.31 | 0.988 | 1.94e-06 | NA | |
Hs 578T | Buparlisib | 2 | sigmoid | sigmoid | Hs578T buparlisib 2 | 8 | 2.513 | 0.665 | -0.42 | 0.251 | 1.61 | -1.0 | 1.24 | 0.998 | 1.14e-08 | NA | 0.595 | 0.0445 | 0.779 | 0.595 | 0.0 | 1.36 | 0.994 | 2.48e-07 | NA | |
Hs 578T | Buparlisib | 3 | sigmoid | sigmoid | Hs578T buparlisib 3 | 8 | 2.890 | 0.778 | -0.425 | 0.233 | 1.71 | -1.0 | 1.4 | 0.998 | 1.34e-08 | NA | 0.622 | 0.0272 | 0.779 | 0.622 | 0.0 | 1.57 | 0.991 | 8.01e-07 | NA | |
Hs 578T | BX-912 | 1 | sigmoid | sigmoid | Hs578T BX-912 1 | 8 | 2.001 | 0.771 | -0.202 | 0.191 | 1.16 | -0.444 | 1.57 | 0.997 | 2.97e-08 | NA | 0.901 | 0.159 | 0.851 | 0.822 | 0.0702 | 1.64 | 0.994 | 1.9e-07 | NA | |
Hs 578T | BX-912 | 2 | sigmoid | sigmoid | Hs578T BX-912 2 | 8 | 2.540 | 1.07 | -0.019 | 0.174 | 1.79 | -0.489 | 1.33 | 0.998 | 6.37e-09 | NA | 1.01 | 0.164 | 0.828 | 1.01 | 0.0 | 1.4 | 0.996 | 7.64e-08 | NA | |
Hs 578T | BX-912 | 3 | sigmoid | sigmoid | Hs578T BX-912 3 | 8 | 2.805 | 1.04 | 0.0121 | 0.125 | 1.09 | -0.0661 | 2.36 | 0.992 | 4.22e-07 | NA | 0.936 | 0.148 | 0.883 | 0.841 | 0.116 | 2.45 | 0.982 | 5.7e-06 | NA | |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
Hs 578T | Alpelisib | 3 | sigmoid | sigmoid | Hs578T alpelisib 3 | 8 | 2.856 | Inf | 0.712 | 0.0759 | 0.872 | 0.616 | 0.828 | 0.963 | 5.21e-05 | NA | Inf | 0.641 | 0.901 | 0.65 | 0.553 | 0.853 | 0.955 | 8.85e-05 | NA | |
Hs 578T | CAL-101 | 1 | sigmoid | sigmoid | Hs578T idelalisib 1 | 8 | 2.050 | 27.9 | 0.72 | 0.0764 | 4.56 | 0.356 | 0.688 | 0.945 | 0.000168 | NA | 18.7 | 0.734 | 0.925 | 18.7 | 0.0 | 0.568 | 0.941 | 0.000203 | NA | |
Hs 578T | CAL-101 | 2 | sigmoid | sigmoid | Hs578T idelalisib 2 | 8 | 2.534 | 57.5 | 0.801 | 0.0636 | 320.0 | -0.507 | 0.408 | 0.979 | 9.58e-06 | NA | Inf | 0.766 | 0.923 | 4.27 | 0.505 | 0.495 | 0.975 | 1.65e-05 | NA | |
Hs 578T | CAL-101 | 3 | sigmoid | sigmoid | Hs578T idelalisib 3 | 8 | 2.874 | Inf | 0.854 | 0.0202 | 1.12 | 0.835 | 1.91 | 0.991 | 6.68e-07 | NA | Inf | 0.805 | 0.972 | 1.07 | 0.781 | 1.92 | 0.99 | 9.77e-07 | NA | |
Hs 578T | Everolimus | 1 | sigmoid | sigmoid | Hs578T everolimus 1 | 8 | 2.030 | 1707115.0 | 0.626 | 0.318 | 0.00576 | 0.429 | 0.1 | 0.895 | 0.00116 | NA | 2.51e+21 | 0.657 | 0.704 | 0.00121 | 0.502 | 0.1 | 0.893 | 0.00124 | NA | |
Hs 578T | Everolimus | 2 | sigmoid | sigmoid | Hs578T everolimus 2 | 8 | 2.550 | 3210000000.0 | 0.626 | 0.335 | 0.000205 | 0.476 | 0.1 | 0.791 | 0.00913 | NA | 18938.0 | 0.59 | 0.627 | 0.000153 | 0.422 | 0.1 | 0.745 | 0.0166 | NA | |
Hs 578T | Pictilisib | 1 | sigmoid | sigmoid | Hs578T pictilisib 1 | 8 | 2.048 | 0.482 | 0.341 | 0.267 | 0.162 | 0.295 | 0.819 | 0.998 | 8.97e-09 | NA | 0.981 | 0.441 | 0.759 | 0.12 | 0.416 | 0.847 | 0.998 | 6.97e-09 | NA | |
Hs 578T | Pictilisib | 2 | sigmoid | sigmoid | Hs578T pictilisib 2 | 8 | 2.512 | 1.93 | 0.45 | 0.194 | 0.4 | 0.333 | 0.696 | 0.98 | 8e-06 | NA | 1.58 | 0.446 | 0.787 | 0.231 | 0.381 | 0.746 | 0.974 | 1.74e-05 | NA | |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA | |
Hs 578T | GDC-0980 | 1 | sigmoid | sigmoid | Hs578T apitolisib 1 | 8 | 1.984 | 0.119 | -0.0587 | 0.419 | 0.141 | -0.0865 | 0.957 | 0.997 | 3.35e-08 | NA | 0.161 | 0.224 | 0.662 | 0.0914 | 0.223 | 1.04 | 0.997 | 2.87e-08 | NA | |
Hs 578T | GDC-0980 | 2 | sigmoid | sigmoid | Hs578T apitolisib 2 | 8 | 2.520 | 0.176 | -0.0558 | 0.391 | 0.275 | -0.201 | 0.758 | 0.997 | 3.91e-08 | NA | 0.159 | 0.151 | 0.627 | 0.121 | 0.1 | 0.818 | 0.998 | 1.45e-08 | NA | |
Hs 578T | GDC-0980 | 3 | sigmoid | sigmoid | Hs578T apitolisib 3 | 8 | 2.831 | 0.243 | 0.145 | 0.315 | 0.19 | 0.112 | 1.02 | 0.998 | 4.02e-09 | NA | 0.179 | 0.206 | 0.665 | 0.114 | 0.196 | 1.09 | 0.999 | 9.76e-10 | NA | |
Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
Hs 578T | Omipalisib | 2 | sigmoid | sigmoid | Hs578T omipalisib 2 | 8 | 2.507 | 0.0155 | -0.52 | 0.766 | 0.239 | -1.0 | 0.402 | 0.993 | 3.45e-07 | NA | 0.0114 | 0.028 | 0.355 | 0.0114 | 0.0 | 0.468 | 0.981 | 6.9e-06 | NA |