Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | Sirolimus | 2 | 72 | flat | flat | BT20 rapamycin 0 2 72 | 8 | 1.952 | Inf | 0.421 | 0.579 | 0.0 | 0.421 | 0.01 | NA | NA | 0.421 | Inf | 0.513 | 0.513 | 0.0 | 0.513 | 0.01 | NA | NA | 0.513 |
BT-20 | Everolimus | 2 | 72 | flat | flat | BT20 everolimus 0 2 72 | 8 | 1.785 | Inf | 0.426 | 0.574 | 0.0 | 0.426 | 0.01 | NA | NA | 0.426 | Inf | 0.547 | 0.547 | 0.0 | 0.547 | 0.01 | NA | NA | 0.547 |
BT-549 | Sirolimus | 3 | 72 | flat | flat | BT549 rapamycin 0 3 72 | 8 | 1.703 | Inf | 0.455 | 0.482 | 0.0 | 0.455 | 0.01 | 0.376 | 0.243 | 0.518 | Inf | 0.582 | 0.626 | 0.0 | 0.582 | 0.01 | 0.436 | 0.179 | 0.625 |
BT-20 | Sirolimus | 3 | 72 | flat | flat | BT20 rapamycin 0 3 72 | 8 | 2.661 | Inf | 0.54 | 0.46 | 0.0 | 0.54 | 0.01 | NA | NA | 0.54 | Inf | 0.499 | 0.499 | 0.0 | 0.499 | 0.01 | NA | NA | 0.499 |
BT-20 | Everolimus | 3 | 72 | flat | flat | BT20 everolimus 0 3 72 | 8 | 2.422 | Inf | 0.475 | 0.456 | 0.0 | 0.475 | 0.01 | 0.602 | 0.0632 | 0.543 | Inf | 0.478 | 0.534 | 0.0 | 0.478 | 0.01 | 0.561 | 0.0844 | 0.534 |
BT-20 | Sirolimus | 1 | 72 | flat | flat | BT20 rapamycin 0 1 72 | 8 | 2.100 | Inf | 0.568 | 0.431 | 0.0 | 0.568 | 0.01 | -9.89 | 1.0 | 0.568 | Inf | 0.6 | 0.601 | 0.0 | 0.6 | 0.01 | -13.0 | 1.0 | 0.6 |
HCC38 | Sirolimus | 1 | 72 | flat | flat | HCC38 rapamycin 0 1 72 | 8 | 1.723 | Inf | 0.531 | 0.429 | 0.0 | 0.531 | 0.01 | 0.623 | 0.0538 | 0.573 | Inf | 0.631 | 0.66 | 0.0 | 0.631 | 0.01 | 0.536 | 0.0998 | 0.661 |
BT-549 | Everolimus | 2 | 72 | flat | flat | BT549 everolimus 0 2 72 | 8 | 1.909 | Inf | 0.566 | 0.407 | 0.0 | 0.566 | 0.01 | -0.646 | 1.0 | 0.594 | Inf | 0.627 | 0.648 | 0.0 | 0.627 | 0.01 | -1.01 | 1.0 | 0.649 |
BT-20 | Everolimus | 1 | 72 | flat | flat | BT20 everolimus 0 1 72 | 8 | 2.002 | Inf | 0.546 | 0.403 | 0.0 | 0.546 | 0.01 | -0.000401 | 1.0 | 0.595 | Inf | 0.597 | 0.638 | 0.0 | 0.597 | 0.01 | -0.327 | 1.0 | 0.636 |
BT-549 | Sirolimus | 2 | 72 | flat | flat | BT549 rapamycin 0 2 72 | 8 | 1.830 | Inf | 0.569 | 0.384 | 0.0 | 0.569 | 0.01 | 0.517 | 0.113 | 0.618 | Inf | 0.642 | 0.677 | 0.0 | 0.642 | 0.01 | 0.465 | 0.153 | 0.679 |
HCC38 | Sirolimus | 2 | 72 | flat | flat | HCC38 rapamycin 0 2 72 | 8 | 2.106 | Inf | 0.588 | 0.371 | 0.0 | 0.588 | 0.01 | 0.496 | 0.128 | 0.629 | Inf | 0.616 | 0.65 | 0.0 | 0.616 | 0.01 | 0.246 | 0.429 | 0.649 |
HCC70 | Everolimus | 1 | 72 | flat | flat | HCC70 everolimus 0 1 72 | 8 | 1.366 | Inf | 0.569 | 0.354 | 0.0 | 0.569 | 0.01 | 0.623 | 0.0534 | 0.643 | Inf | 0.718 | 0.766 | 0.0 | 0.718 | 0.01 | 0.62 | 0.0547 | 0.765 |
Hs 578T | Sirolimus | 2 | flat | flat | Hs578T rapamycin 2 | 8 | 2.536 | Inf | 0.623 | 0.341 | 0.0 | 0.623 | 0.01 | 0.16 | 0.593 | 0.66 | Inf | 0.589 | 0.623 | 0.0 | 0.589 | 0.01 | -0.232 | 1.0 | 0.624 | |
Hs 578T | Sirolimus | 3 | flat | flat | Hs578T rapamycin 3 | 8 | 2.836 | Inf | 0.675 | 0.309 | 0.0 | 0.675 | 0.01 | -1.79 | 1.0 | 0.691 | Inf | 0.604 | 0.621 | 0.0 | 0.604 | 0.01 | -3.02 | 1.0 | 0.621 | |
Hs 578T | Everolimus | 3 | flat | flat | Hs578T everolimus 3 | 8 | 2.848 | Inf | 0.664 | 0.299 | 0.0 | 0.664 | 0.01 | 0.475 | 0.144 | 0.702 | Inf | 0.592 | 0.631 | 0.0 | 0.592 | 0.01 | 0.486 | 0.136 | 0.632 | |
HCC70 | Sirolimus | 2 | 72 | flat | flat | HCC70 rapamycin 0 2 72 | 8 | 1.762 | Inf | 0.685 | 0.257 | 0.0 | 0.685 | 0.01 | 0.531 | 0.103 | 0.741 | Inf | 0.739 | 0.785 | 0.0 | 0.739 | 0.01 | 0.524 | 0.108 | 0.783 |
HCC70 | Everolimus | 2 | 72 | flat | flat | HCC70 everolimus 0 2 72 | 8 | 1.730 | Inf | 0.674 | 0.227 | 0.0 | 0.674 | 0.01 | 0.271 | 0.388 | 0.766 | Inf | 0.735 | 0.812 | 0.0 | 0.735 | 0.01 | 0.264 | 0.399 | 0.807 |
BT-20 | BX-912 | 2 | 72 | flat | flat | BT20 BX-912 0 2 72 | 8 | 1.873 | Inf | 0.683 | 0.213 | 0.0 | 0.683 | 0.01 | 0.118 | 0.686 | 0.777 | Inf | 0.724 | 0.81 | 0.0 | 0.724 | 0.01 | 0.111 | 0.702 | 0.802 |
Hs 578T | Alpelisib | 2 | flat | flat | Hs578T alpelisib 2 | 8 | 2.513 | Inf | 0.668 | 0.131 | 0.0 | 0.668 | 0.01 | 0.599 | 0.0647 | 0.856 | Inf | 0.634 | 0.847 | 0.0 | 0.634 | 0.01 | 0.541 | 0.0969 | 0.833 | |
HCC38 | Alpelisib | 3 | 72 | flat | flat | HCC38 alpelisib 0 3 72 | 8 | 1.398 | Inf | 0.75 | 0.0995 | 0.0 | 0.75 | 0.01 | 0.141 | 0.634 | 0.883 | Inf | 0.829 | 0.932 | 0.0 | 0.829 | 0.01 | 0.113 | 0.698 | 0.92 |
BT-20 | XL147 | 3 | 72 | flat | flat | BT20 pilaralisib 0 3 72 | 8 | 2.647 | Inf | 0.755 | 0.102 | 0.0 | 0.755 | 0.01 | 0.0679 | 0.81 | 0.885 | Inf | 0.708 | 0.871 | 0.0 | 0.708 | 0.01 | 0.0505 | 0.856 | 0.857 |
BT-20 | CAL-101 | 2 | 72 | flat | flat | BT20 idelalisib 0 2 72 | 8 | 1.768 | Inf | 0.818 | 0.0943 | 0.0 | 0.818 | 0.01 | 0.226 | 0.463 | 0.898 | Inf | 0.845 | 0.918 | 0.0 | 0.845 | 0.01 | 0.222 | 0.471 | 0.912 |
BT-20 | BX-912 | 1 | 72 | flat | flat | BT20 BX-912 0 1 72 | 8 | 2.193 | Inf | 0.858 | 0.0928 | 0.0 | 0.858 | 0.01 | 0.25 | 0.422 | 0.903 | Inf | 0.851 | 0.901 | 0.0 | 0.851 | 0.01 | 0.243 | 0.433 | 0.897 |
BT-20 | XL147 | 2 | 72 | flat | flat | BT20 pilaralisib 0 2 72 | 8 | 1.784 | Inf | 0.759 | 0.073 | 0.0 | 0.759 | 0.01 | -0.0058 | 1.0 | 0.907 | Inf | 0.796 | 0.937 | 0.0 | 0.796 | 0.01 | -0.00637 | 1.0 | 0.92 |
HCC70 | Alpelisib | 2 | 72 | flat | flat | HCC70 alpelisib 0 2 72 | 8 | 1.799 | Inf | 0.748 | 0.0777 | 0.0 | 0.748 | 0.01 | 0.00864 | 0.974 | 0.907 | Inf | 0.785 | 0.932 | 0.0 | 0.785 | 0.01 | 0.00534 | 0.984 | 0.919 |