Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 CAL-101 2 72
sigmoid
sigmoid
BT549 idelalisib 0 2 72
 8 1.975
Inf
0.792
0.0561
4.65
0.526
0.693
0.933
0.000307
NA
43.0
0.805
0.946
43.0
0.0
0.548
0.932
0.000314
NA
BT-549 CAL-101 3 72
sigmoid
sigmoid
BT549 idelalisib 0 3 72
 8 1.770
43.0
0.79
0.0687
320.0
-0.664
0.421
0.862
0.00261
NA
118.0
0.822
0.941
118.0
0.0
0.425
0.854
0.00309
NA
BT-549 Everolimus 1 72
sigmoid
sigmoid
BT549 everolimus 0 1 72
 8 1.772
5.64
0.503
0.444
1e-05
0.367
0.1
0.911
0.000706
NA
437200.0
0.603
0.641
0.000146
0.444
0.1
0.858
0.00286
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
BT-549 Pictilisib 3 72
sigmoid
sigmoid
BT549 pictilisib 0 3 72
 8 1.767
1.42
0.276
0.169
4.62
-0.67
0.722
0.998
9.61e-09
NA
2.47
0.452
0.863
2.47
0.0
0.742
0.997
2.13e-08
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA