Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T Trametinib 3
sigmoid
sigmoid
Hs578T trametinib 3
 8 2.830
0.0128
0.0657
0.644
0.0112
0.0447
0.702
0.998
4.02e-09
NA
0.00864
0.168
0.366
0.00512
0.157
0.722
0.998
5.57e-09
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA
Hs 578T WYE-125132 3
sigmoid
sigmoid
Hs578T WYE-132 3
 8 2.876
0.0568
0.189
0.452
0.0346
0.192
0.975
0.996
7.69e-08
NA
0.0403
0.224
0.522
0.0221
0.221
0.97
0.993
4.12e-07
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
Hs 578T ZSTK474 2
sigmoid
sigmoid
Hs578T ZSTK474 2
 8 2.554
0.715
0.187
0.263
5.92
-0.896
0.485
0.995
1.27e-07
NA
0.583
0.264
0.722
0.583
0.0
0.56
0.993
3.28e-07
NA
Hs 578T ZSTK474 3
sigmoid
sigmoid
Hs578T ZSTK474 3
 8 2.863
0.913
0.31
0.201
0.613
0.143
0.846
0.999
6.21e-10
NA
0.607
0.298
0.767
0.329
0.211
0.895
0.999
1.43e-09
NA