Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 Torin1 3 72
sigmoid
sigmoid
HCC38 Torin1 0 3 72
 8 1.441
0.0231
-0.202
0.666
0.0412
-0.248
0.698
0.999
5.79e-10
NA
0.0787
0.266
0.572
0.0306
0.245
0.714
0.999
5.55e-10
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
HCC38 Torin2 2 72
sigmoid
sigmoid
HCC38 Torin2 0 2 72
 8 2.140
0.0146
-0.48
0.793
0.0654
-0.634
0.545
0.993
3.78e-07
NA
0.0176
0.056
0.391
0.015
0.0502
0.68
0.989
1.33e-06
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
HCC38 Trametinib 1 72
sigmoid
sigmoid
HCC38 trametinib 0 1 72
 8 1.733
0.162
0.196
0.407
0.173
-0.0184
0.559
0.948
0.000139
NA
0.568
0.41
0.686
0.161
0.234
0.501
0.947
0.000151
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
HCC38 WYE-125132 1 72
sigmoid
sigmoid
HCC38 WYE-132 0 1 72
 8 1.708
0.0604
0.142
0.447
0.0481
0.134
1.36
0.997
3.43e-08
NA
0.115
0.384
0.669
0.0413
0.381
1.4
0.996
6.46e-08
NA
HCC38 WYE-125132 2 72
sigmoid
sigmoid
HCC38 WYE-132 0 2 72
 8 2.143
0.0568
0.149
0.473
0.0413
0.124
0.896
0.998
9.66e-09
NA
0.078
0.305
0.587
0.0297
0.285
0.875
0.997
1.58e-08
NA
HCC38 WYE-125132 3 72
sigmoid
sigmoid
HCC38 WYE-132 0 3 72
 8 1.449
0.0494
-0.0216
0.518
0.0504
-0.0117
1.18
0.998
9.69e-09
NA
0.128
0.355
0.662
0.0441
0.361
1.2
0.998
9.53e-09
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
HCC38 ZSTK474 2 72
sigmoid
sigmoid
HCC38 ZSTK474 0 2 72
 8 2.253
1.63
0.396
0.196
2.18
-0.0865
0.554
0.984
4.3e-06
NA
2.0
0.445
0.803
1.14
0.135
0.556
0.982
5.91e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC70 Alpelisib 1 72
sigmoid
sigmoid
HCC70 alpelisib 0 1 72
 8 1.383
4.4
0.574
0.105
20.4
-1.0
0.717
0.78
0.0106
NA
11.9
0.718
0.929
11.9
0.0
0.732
0.768
0.0124
NA
HCC70 Alpelisib 2 72
flat
flat
HCC70 alpelisib 0 2 72
 8 1.799
Inf
0.748
0.0777
0.0
0.748
0.01
0.00864
0.974
0.907
Inf
0.785
0.932
0.0
0.785
0.01
0.00534
0.984
0.919
HCC70 Alpelisib 3 72
flat
flat
HCC70 alpelisib 0 3 72
 8 2.465
Inf
0.859
0.027
0.0
0.859
0.01
0.407
0.209
0.961
Inf
0.835
0.968
0.0
0.835
0.01
0.394
0.222
0.954
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC70 AS605240 1 72
sigmoid
sigmoid
HCC70 AS-605240 0 1 72
 8 1.387
10.4
0.487
0.159
0.247
0.497
1.34
0.963
5.14e-05
NA
Inf
0.663
0.894
0.23
0.672
1.39
0.961
6.01e-05
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
HCC70 AS605240 3 72
sigmoid
sigmoid
HCC70 AS-605240 0 3 72
 8 2.447
Inf
0.58
0.112
0.427
0.549
1.18
0.985
3.24e-06
NA
Inf
0.562
0.877
0.345
0.544
1.24
0.982
6.14e-06
NA
HCC70 AZD-6482 1 72
sigmoid
sigmoid
HCC70 AZD6482 0 1 72
 8 1.368
0.0982
0.0128
0.462
0.205
-0.212
0.481
0.975
1.49e-05
NA
0.767
0.394
0.704
0.121
0.305
0.509
0.973
1.9e-05
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA