Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	AZD8055	2	72	sigmoid	sigmoid	HCC70 AZD8055 0 2 72	8	1.724	0.17	0.404	0.346	0.0331	0.385	0.897	0.996	7.36e-08	NA	Inf	0.543	0.728	0.0284	0.531	0.905	0.996	6.22e-08	NA
BT-20	PI103	2	72	sigmoid	sigmoid	BT20 PI-103 0 2 72	8	1.725	0.235	-0.21	0.388	0.289	-0.212	1.7	0.975	1.64e-05	NA	0.319	0.202	0.721	0.239	0.205	1.81	0.961	5.88e-05	NA
HCC70	Torin1	2	72	sigmoid	sigmoid	HCC70 Torin1 0 2 72	8	1.726	0.107	0.323	0.391	0.0276	0.322	0.762	0.997	2.34e-08	NA	3.98	0.49	0.694	0.0225	0.491	0.775	0.997	1.93e-08	NA
BT-20	Dactolisib	2	72	sigmoid	sigmoid	BT20 dactolisib 0 2 72	8	1.727	0.00497	-0.212	0.896	0.00652	-0.186	1.17	0.995	1.45e-07	NA	0.00801	0.2	0.382	0.00505	0.211	1.19	0.994	2.07e-07	NA
BT-549	BX-912	3	72	sigmoid	sigmoid	BT549 BX-912 0 3 72	8	1.728	1.0	0.335	0.109	0.758	0.332	3.91	0.993	2.87e-07	NA	2.46	0.497	0.916	0.73	0.496	3.92	0.992	6.03e-07	NA
HCC70	Everolimus	2	72	flat	flat	HCC70 everolimus 0 2 72	8	1.730	Inf	0.674	0.227	0.0	0.674	0.01	0.271	0.388	0.766	Inf	0.735	0.812	0.0	0.735	0.01	0.264	0.399	0.807
HCC38	AZD-6482	1	72	sigmoid	sigmoid	HCC38 AZD6482 0 1 72	8	1.732	Inf	0.862	0.0239	1.4	0.804	1.03	0.909	0.000761	NA	Inf	0.883	0.98	1.34	0.837	1.03	0.904	0.000873	NA
BT-20	Torin2	2	72	sigmoid	sigmoid	BT20 Torin2 0 2 72	8	1.733	0.00315	-0.761	0.992	0.0484	-0.95	0.389	0.949	0.000131	NA	0.00804	0.0252	0.336	0.00642	0.0613	0.583	0.974	1.77e-05	NA
HCC38	Trametinib	1	72	sigmoid	sigmoid	HCC38 trametinib 0 1 72	8	1.733	0.162	0.196	0.407	0.173	-0.0184	0.559	0.948	0.000139	NA	0.568	0.41	0.686	0.161	0.234	0.501	0.947	0.000151	NA
HCC70	ZSTK474	2	72	sigmoid	sigmoid	HCC70 ZSTK474 0 2 72	8	1.737	0.248	-0.0397	0.324	0.27	-0.0591	1.33	0.992	5.33e-07	NA	0.379	0.28	0.76	0.214	0.28	1.43	0.989	1.22e-06	NA
HCC70	CAL-101	2	72	sigmoid	sigmoid	HCC70 idelalisib 0 2 72	8	1.738	Inf	0.62	0.0432	0.959	0.611	3.13	0.965	4.31e-05	NA	Inf	0.693	0.965	0.935	0.686	3.13	0.96	6.52e-05	NA
HCC38	Alpelisib	1	72	flat	flat	HCC38 alpelisib 0 1 72	8	1.738	Inf	0.757	0.0835	0.0	0.757	0.01	0.593	0.0674	0.909	Inf	0.798	0.929	0.0	0.798	0.01	0.579	0.0744	0.923
HCC38	Buparlisib	1	72	sigmoid	sigmoid	HCC38 buparlisib 0 1 72	8	1.738	0.912	-0.226	0.194	1.46	-0.57	1.62	0.999	9.48e-10	NA	1.2	0.192	0.858	1.12	0.0495	1.66	0.998	4.36e-09	NA
HCC70	PI103	2	72	sigmoid	sigmoid	HCC70 PI-103 0 2 72	8	1.739	1.19	0.0238	0.151	2.67	-0.766	1.15	0.997	2.59e-08	NA	1.68	0.312	0.885	1.68	0.0	1.21	0.996	6.86e-08	NA
BT-20	MK2206	2	72	sigmoid	sigmoid	BT20 MK-2206 0 2 72	8	1.739	0.823	0.0896	0.246	4.34	-1.0	0.661	0.965	4.36e-05	NA	1.47	0.348	0.806	1.47	0.0	0.715	0.947	0.000145	NA
BT-549	KIN001-244	3	72	sigmoid	sigmoid	BT549 KIN001-244 0 3 72	8	1.740	Inf	0.861	0.0287	4.69	0.681	0.74	0.922	0.00047	NA	Inf	0.882	0.975	4.7	0.729	0.732	0.919	0.000531	NA
HCC38	PIK-93	1	72	sigmoid	sigmoid	HCC38 PIK-93 0 1 72	8	1.741	5.24	0.61	0.0782	24.5	-1.0	0.713	0.982	6.07e-06	NA	9.93	0.686	0.935	9.93	0.0	0.729	0.979	9.08e-06	NA
HCC38	ZSTK474	1	72	sigmoid	sigmoid	HCC38 ZSTK474 0 1 72	8	1.742	2.47	0.456	0.132	1.34	0.202	0.843	0.991	7.12e-07	NA	9.02	0.575	0.893	1.0	0.426	0.869	0.99	1.01e-06	NA
BT-20	KIN001-244	2	72	sigmoid	sigmoid	BT20 KIN001-244 0 2 72	8	1.742	Inf	0.85	0.0644	4.47	0.713	0.316	0.721	0.0218	NA	Inf	0.873	0.945	4.51	0.757	0.309	0.715	0.0231	NA
BT-20	Buparlisib	2	72	sigmoid	sigmoid	BT20 buparlisib 0 2 72	8	1.743	0.334	-0.45	0.391	0.844	-0.82	1.05	0.972	2.21e-05	NA	0.487	0.105	0.718	0.487	0.0	1.12	0.948	0.000142	NA
BT-549	Alpelisib	3	72	flat	flat	BT549 alpelisib 0 3 72	8	1.743	Inf	0.817	0.068	0.0	0.817	0.01	-0.0192	1.0	0.915	Inf	0.846	0.942	0.0	0.846	0.01	-0.0162	1.0	0.928
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
BT-549	AZD-6482	3	72	sigmoid	sigmoid	BT549 AZD6482 0 3 72	8	1.744	8.87	0.616	0.0979	2.2	0.324	0.749	0.993	2.93e-07	NA	115.0	0.69	0.918	1.91	0.476	0.744	0.993	4.19e-07	NA
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
HCC38	KIN001-244	1	72	sigmoid	sigmoid	HCC38 KIN001-244 0 1 72	8	1.751	Inf	0.894	0.0375	4.46	0.77	0.479	0.71	0.0244	NA	Inf	0.909	0.968	4.5	0.802	0.474	0.705	0.0256	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)