Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD6482 0 3 72 | 8 | 1.420 | Inf | 0.821 | 0.0615 | 0.324 | 0.826 | 5.0 | 0.849 | 0.00342 | NA | Inf | 0.875 | 0.957 | 0.323 | 0.879 | 5.0 | 0.846 | 0.00367 | NA |
| HCC38 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC38 rapamycin 0 3 72 | 8 | 1.420 | 86.3 | 0.535 | 0.403 | 0.000236 | 0.361 | 0.1 | 0.901 | 0.000982 | NA | 75575.0 | 0.687 | 0.727 | 0.000198 | 0.569 | 0.1 | 0.889 | 0.00136 | NA |
| HCC38 | XL147 | 3 | 72 | sigmoid | sigmoid | HCC38 pilaralisib 0 3 72 | 8 | 1.420 | Inf | 0.909 | 0.0219 | 0.114 | 0.921 | 5.0 | 0.815 | 0.00631 | NA | Inf | 0.936 | 0.985 | 0.114 | 0.945 | 5.0 | 0.813 | 0.00654 | NA |
| HCC38 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 3 72 | 8 | 1.420 | 3.12 | 0.499 | 0.129 | 2.45 | 0.0818 | 0.738 | 0.976 | 1.33e-05 | NA | 20.5 | 0.664 | 0.911 | 2.24 | 0.401 | 0.731 | 0.974 | 1.7e-05 | NA |
| HCC70 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 1 72 | 8 | 1.421 | 0.015 | 0.339 | 0.521 | 0.00411 | 0.34 | 0.879 | 0.966 | 4.1e-05 | NA | Inf | 0.566 | 0.653 | 0.00373 | 0.566 | 0.875 | 0.968 | 3.23e-05 | NA |
| HCC38 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 3 72 | 8 | 1.431 | 0.674 | -0.377 | 0.272 | 1.67 | -1.0 | 1.21 | 0.991 | 6.94e-07 | NA | 1.11 | 0.188 | 0.824 | 1.11 | 0.0 | 1.32 | 0.987 | 2.46e-06 | NA |
| HCC70 | BX-912 | 1 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 1 72 | 8 | 1.436 | 1.08 | -0.227 | 0.134 | 1.2 | -0.255 | 3.86 | 0.99 | 1.07e-06 | NA | 1.35 | 0.256 | 0.916 | 1.14 | 0.242 | 3.87 | 0.986 | 2.78e-06 | NA |
| HCC38 | Everolimus | 3 | 72 | sigmoid | sigmoid | HCC38 everolimus 0 3 72 | 8 | 1.437 | 5.11 | 0.511 | 0.429 | 0.000567 | 0.299 | 0.1 | 0.934 | 0.000284 | NA | 573000000.0 | 0.668 | 0.707 | 0.000349 | 0.53 | 0.1 | 0.932 | 0.000308 | NA |
| HCC38 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC38 apitolisib 0 3 72 | 8 | 1.437 | 0.371 | -0.0189 | 0.29 | 0.513 | -0.179 | 0.946 | 0.993 | 3.35e-07 | NA | 0.96 | 0.359 | 0.808 | 0.393 | 0.295 | 0.998 | 0.993 | 3.51e-07 | NA |
| HCC38 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 3 72 | 8 | 1.441 | 0.0231 | -0.202 | 0.666 | 0.0412 | -0.248 | 0.698 | 0.999 | 5.79e-10 | NA | 0.0787 | 0.266 | 0.572 | 0.0306 | 0.245 | 0.714 | 0.999 | 5.55e-10 | NA |
| HCC70 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 1 72 | 8 | 1.442 | 3.47 | 0.482 | 0.137 | 18.6 | -1.0 | 0.656 | 0.774 | 0.0116 | NA | 10.7 | 0.649 | 0.904 | 10.7 | 0.0 | 0.632 | 0.746 | 0.0163 | NA |
| HCC38 | CAL-101 | 3 | 72 | sigmoid | sigmoid | HCC38 idelalisib 0 3 72 | 8 | 1.443 | Inf | 0.851 | 0.0804 | 4.08 | 0.726 | 0.225 | 0.706 | 0.0254 | NA | Inf | 0.894 | 0.943 | 4.27 | 0.804 | 0.222 | 0.707 | 0.0252 | NA |
| HCC70 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 1 72 | 8 | 1.444 | 0.314 | -0.0266 | 0.337 | 0.618 | -0.336 | 0.758 | 0.991 | 6.35e-07 | NA | 0.925 | 0.353 | 0.775 | 0.521 | 0.172 | 0.737 | 0.99 | 1.08e-06 | NA |
| HCC38 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC38 MK-2206 0 3 72 | 8 | 1.445 | 71.7 | 0.728 | 0.123 | 320.0 | -0.26 | 0.28 | 0.854 | 0.0031 | NA | Inf | 0.81 | 0.912 | 4.3 | 0.61 | 0.332 | 0.834 | 0.00461 | NA |
| HCC38 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC38 omipalisib 0 3 72 | 8 | 1.446 | 0.0145 | -0.503 | 0.802 | 0.0539 | -0.597 | 0.6 | 0.993 | 3.08e-07 | NA | 0.0449 | 0.134 | 0.499 | 0.0308 | 0.107 | 0.644 | 0.993 | 2.98e-07 | NA |
| HCC38 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 3 72 | 8 | 1.449 | 0.0494 | -0.0216 | 0.518 | 0.0504 | -0.0117 | 1.18 | 0.998 | 9.69e-09 | NA | 0.128 | 0.355 | 0.662 | 0.0441 | 0.361 | 1.2 | 0.998 | 9.53e-09 | NA |
| HCC38 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC38 BX-912 0 3 72 | 8 | 1.454 | 0.422 | -0.428 | 0.365 | 0.478 | -0.433 | 5.0 | 0.993 | 4.02e-07 | NA | 0.496 | 0.162 | 0.778 | 0.46 | 0.159 | 5.0 | 0.989 | 1.24e-06 | NA |
| HCC38 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 3 72 | 8 | 1.458 | 2.06 | 0.398 | 0.146 | 5.06 | -0.41 | 0.665 | 0.989 | 1.23e-06 | NA | 6.44 | 0.593 | 0.898 | 3.35 | 0.179 | 0.678 | 0.988 | 1.64e-06 | NA |
| HCC38 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 3 72 | 8 | 1.468 | 0.0082 | -0.197 | 0.778 | 0.0127 | -0.181 | 0.711 | 0.993 | 3.98e-07 | NA | 0.0268 | 0.262 | 0.497 | 0.00923 | 0.277 | 0.757 | 0.994 | 2.62e-07 | NA |
| HCC38 | KIN001-244 | 3 | 72 | flat | flat | HCC38 KIN001-244 0 3 72 | 8 | 1.472 | Inf | 0.849 | 0.0658 | 0.0 | 0.849 | 0.01 | 0.182 | 0.548 | 0.929 | Inf | 0.891 | 0.952 | 0.0 | 0.891 | 0.01 | 0.181 | 0.549 | 0.948 |
| HCC38 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 3 72 | 8 | 1.481 | 1.26 | 0.114 | 0.168 | 3.16 | -0.762 | 1.01 | 0.986 | 2.53e-06 | NA | 2.34 | 0.42 | 0.884 | 2.34 | 0.0 | 1.03 | 0.983 | 4.94e-06 | NA |
| HCC38 | TGX221 | 3 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 3 72 | 8 | 1.484 | 3688.0 | 0.815 | 0.0743 | 320.0 | 0.243 | 0.273 | 0.867 | 0.00233 | NA | 3261706.0 | 0.866 | 0.945 | 320.0 | 0.458 | 0.269 | 0.867 | 0.00238 | NA |
| HCC38 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 3 72 | 8 | 1.486 | 0.229 | 0.132 | 0.342 | 0.19 | 0.108 | 1.3 | 0.969 | 2.85e-05 | NA | 0.689 | 0.429 | 0.766 | 0.176 | 0.409 | 1.25 | 0.962 | 5.31e-05 | NA |
| BT-549 | Everolimus | 3 | 72 | sigmoid | flat | BT549 everolimus 0 3 72 | 8 | 1.587 | 59.5 | 0.533 | 0.425 | 1e-05 | 0.395 | 0.1 | 0.702 | 0.0264 | NA | Inf | 0.656 | 0.685 | 0.0 | 0.656 | 0.01 | 0.48 | 0.141 | 0.685 |
| BT-549 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT549 Torin2 0 3 72 | 8 | 1.613 | 0.00797 | -0.254 | 0.794 | 0.0216 | -0.338 | 0.517 | 0.98 | 8.52e-06 | NA | 0.0236 | 0.204 | 0.458 | 0.0104 | 0.191 | 0.585 | 0.976 | 1.3e-05 | NA |