Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC70 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 3 72 | 8 | 2.446 | 1.51 | 0.227 | 0.0983 | 1.57 | -0.0288 | 1.54 | 0.986 | 2.66e-06 | NA | 1.48 | 0.303 | 0.906 | 1.15 | 0.168 | 1.59 | 0.976 | 1.42e-05 | NA |
HCC70 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 3 72 | 8 | 2.447 | Inf | 0.58 | 0.112 | 0.427 | 0.549 | 1.18 | 0.985 | 3.24e-06 | NA | Inf | 0.562 | 0.877 | 0.345 | 0.544 | 1.24 | 0.982 | 6.14e-06 | NA |
BT-20 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 3 72 | 8 | 2.449 | 1.73 | 0.252 | 0.12 | 3.23 | -0.504 | 1.11 | 0.988 | 1.77e-06 | NA | 1.69 | 0.318 | 0.877 | 1.69 | 0.0 | 1.18 | 0.979 | 9.03e-06 | NA |
HCC70 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 3 72 | 8 | 2.450 | 1.32 | 0.305 | 0.102 | 0.938 | 0.225 | 1.76 | 0.983 | 4.73e-06 | NA | 1.28 | 0.351 | 0.901 | 0.766 | 0.303 | 1.81 | 0.973 | 2.06e-05 | NA |
HCC70 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 3 72 | 8 | 2.458 | 0.0158 | -0.404 | 0.771 | 0.0319 | -0.379 | 0.8 | 0.99 | 8.95e-07 | NA | 0.0148 | 0.051 | 0.376 | 0.0127 | 0.0733 | 1.02 | 0.996 | 4.59e-08 | NA |
BT-20 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT20 Torin2 0 3 72 | 8 | 2.458 | 0.019 | -0.64 | 0.751 | 0.234 | -1.0 | 0.438 | 0.959 | 6.92e-05 | NA | 0.0147 | 0.0148 | 0.379 | 0.0123 | 0.0598 | 0.727 | 0.977 | 1.28e-05 | NA |
HCC70 | TGX221 | 3 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 3 72 | 8 | 2.459 | Inf | 0.7 | 0.0886 | 0.338 | 0.675 | 1.11 | 0.971 | 2.48e-05 | NA | Inf | 0.671 | 0.9 | 0.295 | 0.648 | 1.13 | 0.966 | 3.94e-05 | NA |
Hs 578T | TGX221 | 2 | sigmoid | sigmoid | Hs578T TGX-221 2 | 8 | 2.462 | Inf | 0.816 | 0.0307 | 0.904 | 0.781 | 1.29 | 0.964 | 4.56e-05 | NA | Inf | 0.789 | 0.964 | 0.834 | 0.754 | 1.3 | 0.96 | 6.63e-05 | NA | |
HCC70 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 3 72 | 8 | 2.463 | Inf | 0.56 | 0.361 | 0.00419 | 0.548 | 0.954 | 0.95 | 0.000123 | NA | Inf | 0.542 | 0.618 | 0.00342 | 0.533 | 0.965 | 0.958 | 7.33e-05 | NA |
HCC70 | Alpelisib | 3 | 72 | flat | flat | HCC70 alpelisib 0 3 72 | 8 | 2.465 | Inf | 0.859 | 0.027 | 0.0 | 0.859 | 0.01 | 0.407 | 0.209 | 0.961 | Inf | 0.835 | 0.968 | 0.0 | 0.835 | 0.01 | 0.394 | 0.222 | 0.954 |
HCC70 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 3 72 | 8 | 2.465 | 1.26 | 0.174 | 0.0739 | 1.16 | 0.168 | 5.0 | 0.988 | 1.75e-06 | NA | 1.26 | 0.269 | 0.935 | 1.08 | 0.265 | 5.0 | 0.977 | 1.15e-05 | NA |
Hs 578T | PIK-93 | 2 | sigmoid | sigmoid | Hs578T PIK-93 2 | 8 | 2.467 | 2.43 | 0.415 | 0.0931 | 3.62 | -0.243 | 0.991 | 0.991 | 8.05e-07 | NA | 2.34 | 0.426 | 0.901 | 1.93 | 0.0909 | 1.04 | 0.987 | 2.24e-06 | NA | |
BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
HCC70 | KIN001-244 | 3 | 72 | flat | flat | HCC70 KIN001-244 0 3 72 | 8 | 2.472 | Inf | 0.916 | 0.0295 | 0.0 | 0.916 | 0.01 | -0.0208 | 1.0 | 0.969 | Inf | 0.899 | 0.965 | 0.0 | 0.899 | 0.01 | -0.00883 | 1.0 | 0.963 |
HCC70 | XL147 | 3 | 72 | flat | flat | HCC70 pilaralisib 0 3 72 | 8 | 2.478 | Inf | 1.03 | -0.0199 | 0.0 | 1.03 | 0.01 | -0.318 | 1.0 | 1.02 | Inf | 1.03 | 1.03 | 0.0 | 1.03 | 0.01 | -0.331 | 1.0 | 1.02 |
Hs 578T | AZD8055 | 2 | sigmoid | sigmoid | Hs578T AZD8055 2 | 8 | 2.480 | 0.0521 | 0.149 | 0.469 | 0.0387 | 0.142 | 1.13 | 0.999 | 3.49e-10 | NA | 0.0495 | 0.253 | 0.557 | 0.0273 | 0.249 | 1.16 | 0.999 | 4.45e-10 | NA | |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
BT-20 | PI103 | 3 | 72 | sigmoid | sigmoid | BT20 PI-103 0 3 72 | 8 | 2.496 | 0.373 | 0.0139 | 0.282 | 0.387 | -0.0286 | 1.52 | 0.994 | 1.99e-07 | NA | 0.359 | 0.183 | 0.735 | 0.279 | 0.162 | 1.56 | 0.988 | 1.71e-06 | NA |
BT-20 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | BT20 apitolisib 0 3 72 | 8 | 2.502 | 0.0976 | -0.115 | 0.437 | 0.107 | -0.0716 | 1.53 | 0.994 | 2.41e-07 | NA | 0.0894 | 0.13 | 0.62 | 0.0732 | 0.163 | 1.96 | 0.996 | 6.83e-08 | NA |
HCC70 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC70 ZSTK474 0 3 72 | 8 | 2.502 | 0.455 | 0.176 | 0.223 | 0.345 | 0.155 | 1.35 | 0.991 | 8.07e-07 | NA | 0.401 | 0.265 | 0.782 | 0.24 | 0.274 | 1.55 | 0.987 | 1.99e-06 | NA |
Hs 578T | PI103 | 2 | sigmoid | sigmoid | Hs578T PI-103 2 | 8 | 2.503 | 0.223 | -0.0213 | 0.356 | 0.303 | -0.15 | 0.858 | 0.999 | 7.33e-10 | NA | 0.206 | 0.167 | 0.661 | 0.152 | 0.121 | 0.921 | 0.999 | 1.9e-09 | NA | |
Hs 578T | KIN001-244 | 2 | sigmoid | sigmoid | Hs578T KIN001-244 2 | 8 | 2.505 | Inf | 0.819 | 0.0357 | 4.8 | 0.531 | 1.14 | 0.891 | 0.0013 | NA | 44.3 | 0.788 | 0.957 | 4.79 | 0.457 | 1.1 | 0.878 | 0.0018 | NA | |
Hs 578T | Omipalisib | 2 | sigmoid | sigmoid | Hs578T omipalisib 2 | 8 | 2.507 | 0.0155 | -0.52 | 0.766 | 0.239 | -1.0 | 0.402 | 0.993 | 3.45e-07 | NA | 0.0114 | 0.028 | 0.355 | 0.0114 | 0.0 | 0.468 | 0.981 | 6.9e-06 | NA | |
Hs 578T | AZD-6482 | 2 | sigmoid | sigmoid | Hs578T AZD6482 2 | 8 | 2.508 | 6.35 | 0.602 | 0.121 | 74.8 | -1.0 | 0.445 | 0.998 | 1.12e-08 | NA | 6.4 | 0.573 | 0.86 | 6.4 | 0.0 | 0.475 | 0.996 | 6.36e-08 | NA | |
Hs 578T | Dactolisib | 2 | sigmoid | sigmoid | Hs578T dactolisib 2 | 8 | 2.509 | 0.0128 | -0.0617 | 0.655 | 0.0126 | 0.00741 | 0.79 | 0.974 | 1.78e-05 | NA | 0.0105 | 0.15 | 0.405 | 0.00638 | 0.203 | 1.04 | 0.985 | 3.67e-06 | NA |