Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	WYE-125132	2		sigmoid	sigmoid	Hs578T WYE-132 2	8	2.544	0.0374	0.152	0.505	0.0268	0.147	1.04	0.999	8.81e-10	NA	0.0344	0.246	0.516	0.0183	0.239	1.03	0.999	2.53e-09	NA
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
HCC38	Torin2	3	72	sigmoid	sigmoid	HCC38 Torin2 0 3 72	8	1.385	0.013	-0.624	0.855	0.0547	-0.706	0.615	0.996	8.13e-08	NA	0.0407	0.0986	0.484	0.0311	0.0829	0.669	0.997	3.31e-08	NA
HCC38	Omipalisib	3	72	sigmoid	sigmoid	HCC38 omipalisib 0 3 72	8	1.446	0.0145	-0.503	0.802	0.0539	-0.597	0.6	0.993	3.08e-07	NA	0.0449	0.134	0.499	0.0308	0.107	0.644	0.993	2.98e-07	NA
Hs 578T	WYE-125132	1		sigmoid	sigmoid	Hs578T WYE-132 1	8	2.015	0.0322	0.0601	0.551	0.0286	0.0544	0.962	0.998	4.17e-09	NA	0.0469	0.278	0.55	0.0207	0.275	0.978	0.999	2.33e-09	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
BT-20	WYE-125132	3	72	sigmoid	sigmoid	BT20 WYE-132 0 3 72	8	2.654	0.0504	0.282	0.465	0.0254	0.236	0.929	0.922	0.000468	NA	0.048	0.307	0.526	0.0182	0.246	0.698	0.918	0.000553	NA
HCC1806	Torin2	1	72	sigmoid	sigmoid	HCC1806 Torin2 0 1 72	8	2.759	0.0569	-0.203	0.582	0.0763	-0.234	1.3	0.996	6.76e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.09e-07	NA
HCC1806	Torin2	2	72	sigmoid	sigmoid	HCC1806 Torin2 0 2 72	8	2.843	0.0589	-0.181	0.57	0.0771	-0.211	1.3	0.996	6.72e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.08e-07	NA
HCC1806	Torin2	3	72	sigmoid	sigmoid	HCC1806 Torin2 0 3 72	8	3.212	0.0678	-0.0927	0.522	0.0798	-0.12	1.32	0.996	6.56e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.09e-07	NA
Hs 578T	AZD8055	2		sigmoid	sigmoid	Hs578T AZD8055 2	8	2.480	0.0521	0.149	0.469	0.0387	0.142	1.13	0.999	3.49e-10	NA	0.0495	0.253	0.557	0.0273	0.249	1.16	0.999	4.45e-10	NA
HCC38	Omipalisib	2	72	sigmoid	sigmoid	HCC38 omipalisib 0 2 72	8	2.124	0.0404	-0.47	0.634	0.45	-1.0	0.456	0.979	9.71e-06	NA	0.0507	0.0595	0.494	0.0507	0.0	0.556	0.96	6.44e-05	NA
BT-549	WYE-125132	2	72	sigmoid	sigmoid	BT549 WYE-132 0 2 72	8	1.780	0.0329	0.0784	0.528	0.0287	0.0811	1.29	0.988	1.59e-06	NA	0.0545	0.333	0.604	0.0236	0.337	1.34	0.986	2.87e-06	NA
BT-549	WYE-125132	3	72	sigmoid	sigmoid	BT549 WYE-132 0 3 72	8	1.662	0.0271	0.0265	0.567	0.0245	0.0525	1.1	0.992	5.72e-07	NA	0.0574	0.33	0.592	0.0203	0.345	1.13	0.991	6.54e-07	NA
HCC38	Omipalisib	1	72	sigmoid	sigmoid	HCC38 omipalisib 0 1 72	8	1.760	0.0231	-0.316	0.672	0.152	-0.638	0.438	0.97	2.61e-05	NA	0.0585	0.151	0.512	0.0499	0.0356	0.465	0.956	8.65e-05	NA
BT-20	Torin1	1	72	sigmoid	sigmoid	BT20 Torin1 0 1 72	8	2.022	0.0383	-0.105	0.566	0.0658	-0.179	0.565	0.991	7.45e-07	NA	0.0591	0.197	0.536	0.0286	0.182	0.624	0.994	2.54e-07	NA
Hs 578T	AZD8055	1		sigmoid	sigmoid	Hs578T AZD8055 1	8	2.009	0.0391	0.073	0.531	0.0347	0.0546	0.975	0.995	1.39e-07	NA	0.0591	0.286	0.565	0.0259	0.27	0.941	0.994	1.73e-07	NA
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
HCC70	Torin2	2	72	sigmoid	sigmoid	HCC70 Torin2 0 2 72	8	1.826	0.0342	-0.522	0.671	0.401	-1.0	0.446	0.979	9.23e-06	NA	0.0639	0.0733	0.507	0.0639	0.0	0.462	0.969	2.98e-05	NA
BT-20	GDC-0980	2	72	sigmoid	sigmoid	BT20 apitolisib 0 2 72	8	1.659	0.0456	-0.414	0.639	0.0629	-0.33	1.58	0.993	4.18e-07	NA	0.0641	0.131	0.575	0.0506	0.168	1.74	0.995	1.2e-07	NA
HCC1806	Omipalisib	1	72	sigmoid	sigmoid	HCC1806 omipalisib 0 1 72	8	2.764	0.104	-0.333	0.49	0.508	-0.746	0.577	0.98	8.23e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC1806	Omipalisib	2	72	sigmoid	sigmoid	HCC1806 omipalisib 0 2 72	8	2.849	0.112	-0.311	0.479	0.543	-0.739	0.573	0.98	8.07e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC1806	Omipalisib	3	72	sigmoid	sigmoid	HCC1806 omipalisib 0 3 72	8	3.217	0.147	-0.221	0.437	0.71	-0.707	0.559	0.981	7.41e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)