Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	Torin2	3		sigmoid	sigmoid	Hs578T Torin2 3	8	2.844	0.0272	-0.327	0.667	0.144	-0.614	0.48	0.994	2.62e-07	NA	0.0164	0.0451	0.381	0.0148	0.0308	0.638	0.995	1.07e-07	NA
BT-549	Omipalisib	2	72	sigmoid	sigmoid	BT549 omipalisib 0 2 72	8	1.990	0.0104	-0.291	0.751	0.026	-0.32	0.542	0.966	4.09e-05	NA	0.0175	0.127	0.422	0.011	0.118	0.58	0.953	0.000102	NA
HCC38	Torin2	2	72	sigmoid	sigmoid	HCC38 Torin2 0 2 72	8	2.140	0.0146	-0.48	0.793	0.0654	-0.634	0.545	0.993	3.78e-07	NA	0.0176	0.056	0.391	0.015	0.0502	0.68	0.989	1.33e-06	NA
BT-549	Torin2	2	72	sigmoid	sigmoid	BT549 Torin2 0 2 72	8	1.824	0.00997	-0.281	0.767	0.0212	-0.282	0.594	0.975	1.47e-05	NA	0.0177	0.155	0.438	0.00929	0.188	0.734	0.973	2.02e-05	NA
Hs 578T	Torin1	2		sigmoid	sigmoid	Hs578T Torin1 2	8	2.548	0.0205	0.144	0.566	0.0148	0.14	1.0	0.999	3.13e-10	NA	0.0182	0.241	0.463	0.00975	0.24	1.04	0.999	6.11e-10	NA
BT-549	Torin2	1	72	sigmoid	sigmoid	BT549 Torin2 0 1 72	8	1.771	0.0095	-0.218	0.756	0.0155	-0.193	0.672	0.985	3.06e-06	NA	0.0183	0.19	0.452	0.00874	0.218	0.775	0.988	1.88e-06	NA
BT-20	AZD8055	2	72	sigmoid	sigmoid	BT20 AZD8055 0 2 72	8	1.951	0.00909	0.155	0.651	0.00651	0.115	0.785	0.936	0.000258	NA	0.0185	0.343	0.477	0.00469	0.311	0.706	0.934	0.000289	NA
HCC38	Dactolisib	1	72	sigmoid	sigmoid	HCC38 dactolisib 0 1 72	8	1.821	0.0109	-0.0403	0.672	0.0104	0.0212	0.892	0.985	3.44e-06	NA	0.0194	0.263	0.492	0.00757	0.301	0.975	0.988	1.65e-06	NA
BT-549	Omipalisib	3	72	sigmoid	sigmoid	BT549 omipalisib 0 3 72	8	1.777	0.0114	-0.23	0.753	0.0162	-0.178	0.879	0.988	1.64e-06	NA	0.0201	0.183	0.459	0.0112	0.208	0.924	0.991	6.53e-07	NA
BT-20	Torin1	3	72	sigmoid	sigmoid	BT20 Torin1 0 3 72	8	2.569	0.0237	0.0343	0.572	0.0199	0.0736	0.899	0.993	2.77e-07	NA	0.0208	0.184	0.46	0.0119	0.204	0.944	0.997	2.51e-08	NA
Hs 578T	Torin2	1		sigmoid	sigmoid	Hs578T Torin2 1	8	2.031	0.015	-0.405	0.761	0.0631	-0.56	0.522	0.992	5.31e-07	NA	0.021	0.0851	0.419	0.0163	0.0756	0.64	0.993	3.63e-07	NA
Hs 578T	Torin1	3		sigmoid	sigmoid	Hs578T Torin1 3	8	2.860	0.0307	0.174	0.514	0.0196	0.176	0.964	0.999	2.01e-09	NA	0.0212	0.218	0.469	0.0119	0.222	1.02	0.998	1.17e-08	NA
BT-20	WYE-125132	2	72	sigmoid	sigmoid	BT20 WYE-132 0 2 72	8	2.053	0.012	0.142	0.633	0.00936	0.072	0.621	0.909	0.000752	NA	0.0232	0.316	0.475	0.00613	0.255	0.536	0.894	0.00119	NA
BT-549	Torin1	3	72	sigmoid	sigmoid	BT549 Torin1 0 3 72	8	1.757	0.0123	0.026	0.659	0.0112	0.0466	1.02	0.997	3.77e-08	NA	0.0235	0.309	0.513	0.00878	0.322	1.05	0.997	1.65e-08	NA
BT-549	Torin2	3	72	sigmoid	sigmoid	BT549 Torin2 0 3 72	8	1.613	0.00797	-0.254	0.794	0.0216	-0.338	0.517	0.98	8.52e-06	NA	0.0236	0.204	0.458	0.0104	0.191	0.585	0.976	1.3e-05	NA
BT-20	Torin2	1	72	sigmoid	sigmoid	BT20 Torin2 0 1 72	8	2.018	0.0185	-0.739	0.803	0.158	-1.0	0.511	0.986	2.9e-06	NA	0.0245	0.0164	0.415	0.0245	0.0	0.616	0.99	1.06e-06	NA
BT-549	Torin1	2	72	sigmoid	sigmoid	BT549 Torin1 0 2 72	8	1.881	0.0165	0.0298	0.618	0.0147	0.0572	1.03	0.993	4.2e-07	NA	0.0262	0.287	0.52	0.0111	0.306	1.1	0.99	9.68e-07	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
HCC38	Dactolisib	3	72	sigmoid	sigmoid	HCC38 dactolisib 0 3 72	8	1.468	0.0082	-0.197	0.778	0.0127	-0.181	0.711	0.993	3.98e-07	NA	0.0268	0.262	0.497	0.00923	0.277	0.757	0.994	2.62e-07	NA
BT-549	Omipalisib	1	72	sigmoid	sigmoid	BT549 omipalisib 0 1 72	8	1.789	0.0164	-0.2	0.693	0.0219	-0.149	0.887	0.986	2.66e-06	NA	0.0272	0.194	0.495	0.0148	0.228	0.993	0.991	8.42e-07	NA
BT-20	AZD8055	3	72	sigmoid	sigmoid	BT20 AZD8055 0 3 72	8	2.694	0.0351	0.345	0.472	0.0116	0.313	0.89	0.934	0.000286	NA	0.0291	0.343	0.506	0.00813	0.306	0.743	0.922	0.000471	NA
BT-20	Dactolisib	1	72	sigmoid	sigmoid	BT20 dactolisib 0 1 72	8	2.055	0.0223	-0.205	0.652	0.0609	-0.33	0.505	0.979	9.18e-06	NA	0.0305	0.15	0.475	0.0171	0.153	0.631	0.979	9.75e-06	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
Hs 578T	Torin1	1		sigmoid	sigmoid	Hs578T Torin1 1	8	1.956	0.0217	0.0183	0.598	0.0203	0.0286	0.911	0.994	1.81e-07	NA	0.0321	0.267	0.524	0.0141	0.28	0.995	0.996	8.78e-08	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)