Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T KIN001-244 2
sigmoid
sigmoid
Hs578T KIN001-244 2
 8 2.505
Inf
0.819
0.0357
4.8
0.531
1.14
0.891
0.0013
NA
44.3
0.788
0.957
4.79
0.457
1.1
0.878
0.0018
NA
BT-20 AS605240 2 72
sigmoid
sigmoid
BT20 AS-605240 0 2 72
 8 1.846
4509270.0
0.729
0.203
320.0
0.31
0.101
0.845
0.00373
NA
4.4e+12
0.764
0.821
56.5
0.46
0.101
0.843
0.00388
NA
HCC38 AS605240 2 72
sigmoid
sigmoid
HCC38 AS-605240 0 2 72
 8 2.200
17.4
0.642
0.114
4.07
0.256
0.493
0.936
0.000265
NA
46.2
0.648
0.882
1.68
0.411
0.522
0.929
0.000356
NA
HCC1806 PIK-93 2 72
sigmoid
sigmoid
HCC1806 PIK-93 0 2 72
 8 2.838
41.1
0.857
0.038
265.0
-1.0
0.59
0.858
0.00286
NA
46.6
0.811
0.948
46.6
0.0
0.57
0.84
0.00406
NA
HCC1806 PIK-93 3 72
sigmoid
sigmoid
HCC1806 PIK-93 0 3 72
 8 3.206
56.0
0.873
0.0337
320.0
-0.872
0.579
0.859
0.00279
NA
46.6
0.811
0.948
46.6
0.0
0.57
0.84
0.00406
NA
HCC1806 PIK-93 1 72
sigmoid
sigmoid
HCC1806 PIK-93 0 1 72
 8 2.753
44.0
0.853
0.0391
304.0
-1.0
0.568
0.858
0.00285
NA
46.6
0.811
0.948
46.6
0.0
0.57
0.84
0.00406
NA
BT-549 TGX221 3 72
sigmoid
sigmoid
BT549 TGX-221 0 3 72
 8 1.768
93790.0
0.805
0.0889
320.0
0.356
0.22
0.707
0.0251
NA
49050766.0
0.834
0.923
320.0
0.461
0.214
0.703
0.0263
NA
Hs 578T KIN001-244 3
sigmoid
sigmoid
Hs578T KIN001-244 3
 8 2.888
Inf
0.866
0.00909
5.05
0.617
1.35
0.858
0.00289
NA
50.0
0.818
0.988
5.2
0.474
1.31
0.842
0.00391
NA
BT-549 Sirolimus 1 72
sigmoid
sigmoid
BT549 rapamycin 0 1 72
 8 1.817
3.62
0.51
0.438
0.000148
0.318
0.1
0.87
0.00218
NA
506850.0
0.6
0.638
8.82e-05
0.447
0.1
0.8
0.00802
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
Hs 578T AZD-6482 3
sigmoid
sigmoid
Hs578T AZD6482 3
 8 2.832
6.09
0.667
0.0547
24.1
-1.0
0.799
0.989
1.5e-06
NA
5.12
0.597
0.93
5.12
0.0
0.861
0.985
3.33e-06
NA
HCC70 Torin1 3 72
sigmoid
sigmoid
HCC70 Torin1 0 3 72
 8 2.415
3.74
0.495
0.279
0.0352
0.496
1.02
0.994
2.6e-07
NA
5.73
0.495
0.709
0.0284
0.498
1.06
0.994
2.26e-07
NA
HCC38 Everolimus 3 72
sigmoid
sigmoid
HCC38 everolimus 0 3 72
 8 1.437
5.11
0.511
0.429
0.000567
0.299
0.1
0.934
0.000284
NA
573000000.0
0.668
0.707
0.000349
0.53
0.1
0.932
0.000308
NA
Hs 578T AS605240 3
sigmoid
sigmoid
Hs578T AS-605240 3
 8 2.856
63.8
0.588
0.0965
0.826
0.494
1.03
0.983
4.89e-06
NA
5.75
0.518
0.879
0.552
0.465
1.14
0.981
6.87e-06
NA
HCC70 TGX221 2 72
sigmoid
sigmoid
HCC70 TGX-221 0 2 72
 8 1.786
1.77
0.467
0.233
0.531
0.227
0.503
0.948
0.000139
NA
5.85
0.575
0.806
3.44
0.0897
0.372
0.937
0.000249
NA
HCC70 PIK-93 2 72
sigmoid
sigmoid
HCC70 PIK-93 0 2 72
 8 1.705
4.34
0.647
0.0132
9.3
-1.0
1.44
0.888
0.0014
NA
6.01
0.718
0.991
6.01
0.0
1.49
0.872
0.00208
NA
HCC38 MK2206 1 72
sigmoid
sigmoid
HCC38 MK-2206 0 1 72
 8 1.789
19.4
0.698
0.0995
320.0
-0.949
0.38
0.956
8.33e-05
NA
61.8
0.746
0.914
61.8
0.0
0.386
0.951
0.000115
NA
Hs 578T AZD-6482 2
sigmoid
sigmoid
Hs578T AZD6482 2
 8 2.508
6.35
0.602
0.121
74.8
-1.0
0.445
0.998
1.12e-08
NA
6.4
0.573
0.86
6.4
0.0
0.475
0.996
6.36e-08
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
BT-549 PIK-93 3 72
sigmoid
sigmoid
BT549 PIK-93 0 3 72
 8 1.807
20.1
0.719
0.0848
231.0
-1.0
0.45
0.716
0.0229
NA
67.9
0.761
0.925
67.9
0.0
0.431
0.686
0.0309
NA
HCC38 Sirolimus 3 72
sigmoid
sigmoid
HCC38 rapamycin 0 3 72
 8 1.420
86.3
0.535
0.403
0.000236
0.361
0.1
0.901
0.000982
NA
75575.0
0.687
0.727
0.000198
0.569
0.1
0.889
0.00136
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
Hs 578T Sirolimus 1
sigmoid
sigmoid
Hs578T rapamycin 1
 8 2.013
110643.0
0.587
0.358
0.000237
0.432
0.1
0.879
0.00178
NA
9.61e+11
0.628
0.672
0.000175
0.487
0.1
0.851
0.00332
NA
HCC38 PIK-93 1 72
sigmoid
sigmoid
HCC38 PIK-93 0 1 72
 8 1.741
5.24
0.61
0.0782
24.5
-1.0
0.713
0.982
6.07e-06
NA
9.93
0.686
0.935
9.93
0.0
0.729
0.979
9.08e-06
NA