Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 Pictilisib 3 72
sigmoid
sigmoid
HCC38 pictilisib 0 3 72
 8 1.420
3.12
0.499
0.129
2.45
0.0818
0.738
0.976
1.33e-05
NA
20.5
0.664
0.911
2.24
0.401
0.731
0.974
1.7e-05
NA
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
HCC70 Sirolimus 3 72
sigmoid
sigmoid
HCC70 rapamycin 0 3 72
 8 2.548
310.0
0.732
0.227
0.000433
0.63
0.1
0.676
0.034
NA
22876.0
0.693
0.736
0.000237
0.58
0.1
0.659
0.0397
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
BT-549 BX-912 3 72
sigmoid
sigmoid
BT549 BX-912 0 3 72
 8 1.728
1.0
0.335
0.109
0.758
0.332
3.91
0.993
2.87e-07
NA
2.46
0.497
0.916
0.73
0.496
3.92
0.992
6.03e-07
NA
BT-549 Pictilisib 3 72
sigmoid
sigmoid
BT549 pictilisib 0 3 72
 8 1.767
1.42
0.276
0.169
4.62
-0.67
0.722
0.998
9.61e-09
NA
2.47
0.452
0.863
2.47
0.0
0.742
0.997
2.13e-08
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
Hs 578T Everolimus 1
sigmoid
sigmoid
Hs578T everolimus 1
 8 2.030
1707115.0
0.626
0.318
0.00576
0.429
0.1
0.895
0.00116
NA
2.51e+21
0.657
0.704
0.00121
0.502
0.1
0.893
0.00124
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
Hs 578T TGX221 1
sigmoid
sigmoid
Hs578T TGX-221 1
 8 2.019
14.6
0.686
0.0936
23.9
-0.133
0.479
0.995
1.07e-07
NA
27.2
0.708
0.91
11.5
0.171
0.484
0.995
1.48e-07
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
BT-549 Trametinib 1 72
sigmoid
sigmoid
BT549 trametinib 0 1 72
 8 1.812
Inf
0.596
0.202
0.131
0.523
0.61
0.959
6.65e-05
NA
28.3
0.664
0.828
3.47
0.254
0.337
0.933
0.000305
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
BT-549 TGX221 2 72
sigmoid
sigmoid
BT549 TGX-221 0 2 72
 8 1.927
17.5
0.772
0.0551
123.0
-1.0
0.562
0.907
0.000795
NA
32.3
0.792
0.949
32.3
3.45e-05
0.58
0.899
0.00102
NA
HCC38 TGX221 3 72
sigmoid
sigmoid
HCC38 TGX-221 0 3 72
 8 1.484
3688.0
0.815
0.0743
320.0
0.243
0.273
0.867
0.00233
NA
3261706.0
0.866
0.945
320.0
0.458
0.269
0.867
0.00238
NA
HCC70 PIK-93 3 72
sigmoid
sigmoid
HCC70 PIK-93 0 3 72
 8 2.519
21.2
0.756
0.0663
181.0
-1.0
0.513
0.851
0.00333
NA
34.1
0.721
0.92
34.1
0.0
0.473
0.831
0.00487
NA
HCC70 Everolimus 3 72
sigmoid
sigmoid
HCC70 everolimus 0 3 72
 8 2.401
530906.0
0.749
0.195
0.072
0.603
0.1
0.706
0.0255
NA
381983.0
0.725
0.782
0.0137
0.59
0.1
0.706
0.0255
NA
Hs 578T Alpelisib 1
sigmoid
sigmoid
Hs578T alpelisib 1
 8 2.097
2.3
0.449
0.205
42.0
-1.0
0.378
0.954
9.56e-05
NA
3.9
0.508
0.803
3.9
0.0
0.401
0.94
0.000216
NA
HCC70 Torin1 2 72
sigmoid
sigmoid
HCC70 Torin1 0 2 72
 8 1.726
0.107
0.323
0.391
0.0276
0.322
0.762
0.997
2.34e-08
NA
3.98
0.49
0.694
0.0225
0.491
0.775
0.997
1.93e-08
NA
BT-549 CAL-101 2 72
sigmoid
sigmoid
BT549 idelalisib 0 2 72
 8 1.975
Inf
0.792
0.0561
4.65
0.526
0.693
0.933
0.000307
NA
43.0
0.805
0.946
43.0
0.0
0.548
0.932
0.000314
NA
BT-549 Everolimus 1 72
sigmoid
sigmoid
BT549 everolimus 0 1 72
 8 1.772
5.64
0.503
0.444
1e-05
0.367
0.1
0.911
0.000706
NA
437200.0
0.603
0.641
0.000146
0.444
0.1
0.858
0.00286
NA