Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T Trametinib 1
sigmoid
sigmoid
Hs578T trametinib 1
 8 2.044
0.00353
-0.00904
0.765
0.00516
-0.0906
0.437
0.992
4.85e-07
NA
0.00661
0.238
0.385
0.00213
0.201
0.456
0.993
3e-07
NA
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
BT-549 WYE-125132 1 72
sigmoid
sigmoid
BT549 WYE-132 0 1 72
 8 1.787
0.0317
0.11
0.542
0.026
0.0962
1.09
0.996
5.11e-08
NA
0.062
0.349
0.589
0.0213
0.338
1.05
0.997
3.82e-08
NA
BT-20 Dactolisib 3 72
sigmoid
sigmoid
BT20 dactolisib 0 3 72
 8 2.420
0.0111
0.024
0.639
0.00921
0.0987
1.17
0.982
6.27e-06
NA
0.0106
0.198
0.427
0.00645
0.241
1.32
0.99
9.14e-07
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
Hs 578T GDC-0980 3
sigmoid
sigmoid
Hs578T apitolisib 3
 8 2.831
0.243
0.145
0.315
0.19
0.112
1.02
0.998
4.02e-09
NA
0.179
0.206
0.665
0.114
0.196
1.09
0.999
9.76e-10
NA
Hs 578T Dactolisib 3
sigmoid
sigmoid
Hs578T dactolisib 3
 8 2.837
0.0118
0.0569
0.624
0.00848
0.115
0.799
0.96
6.53e-05
NA
0.00728
0.164
0.377
0.0043
0.212
1.05
0.968
3.34e-05
NA
BT-20 AZD8055 2 72
sigmoid
sigmoid
BT20 AZD8055 0 2 72
 8 1.951
0.00909
0.155
0.651
0.00651
0.115
0.785
0.936
0.000258
NA
0.0185
0.343
0.477
0.00469
0.311
0.706
0.934
0.000289
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC38 PI103 1 72
sigmoid
sigmoid
HCC38 PI-103 0 1 72
 8 1.782
0.755
0.222
0.201
0.601
0.12
1.2
0.996
4.45e-08
NA
1.39
0.416
0.839
0.494
0.359
1.23
0.995
1.01e-07
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC38 AZD8055 2 72
sigmoid
sigmoid
HCC38 AZD8055 0 2 72
 8 2.128
0.0616
0.16
0.467
0.045
0.124
0.912
0.993
3.13e-07
NA
0.0875
0.314
0.594
0.0332
0.284
0.869
0.991
6.5e-07
NA
HCC38 WYE-125132 2 72
sigmoid
sigmoid
HCC38 WYE-132 0 2 72
 8 2.143
0.0568
0.149
0.473
0.0413
0.124
0.896
0.998
9.66e-09
NA
0.078
0.305
0.587
0.0297
0.285
0.875
0.997
1.58e-08
NA
Hs 578T TGX221 1
sigmoid
sigmoid
Hs578T TGX-221 1
 8 2.019
14.6
0.686
0.0936
23.9
-0.133
0.479
0.995
1.07e-07
NA
27.2
0.708
0.91
11.5
0.171
0.484
0.995
1.48e-07
NA
HCC38 WYE-125132 1 72
sigmoid
sigmoid
HCC38 WYE-132 0 1 72
 8 1.708
0.0604
0.142
0.447
0.0481
0.134
1.36
0.997
3.43e-08
NA
0.115
0.384
0.669
0.0413
0.381
1.4
0.996
6.46e-08
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
HCC38 AZD8055 1 72
sigmoid
sigmoid
HCC38 AZD8055 0 1 72
 8 1.773
0.052
0.151
0.479
0.0381
0.136
1.02
0.992
4.28e-07
NA
0.116
0.375
0.633
0.0313
0.363
0.987
0.993
3.89e-07
NA
BT-549 AZD8055 2 72
sigmoid
sigmoid
BT549 AZD8055 0 2 72
 8 1.848
0.0373
0.14
0.506
0.0287
0.138
1.23
0.994
2.1e-07
NA
0.0653
0.354
0.605
0.0239
0.35
1.2
0.995
1.39e-07
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA
BT-549 AZD8055 1 72
sigmoid
sigmoid
BT549 AZD8055 0 1 72
 8 1.781
0.0305
0.165
0.526
0.0228
0.14
1.13
0.992
4.7e-07
NA
0.0615
0.382
0.599
0.0189
0.367
1.12
0.994
1.9e-07
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA