Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
Hs 578T Trametinib 3
sigmoid
sigmoid
Hs578T trametinib 3
 8 2.830
0.0128
0.0657
0.644
0.0112
0.0447
0.702
0.998
4.02e-09
NA
0.00864
0.168
0.366
0.00512
0.157
0.722
0.998
5.57e-09
NA
BT-549 Torin1 3 72
sigmoid
sigmoid
BT549 Torin1 0 3 72
 8 1.757
0.0123
0.026
0.659
0.0112
0.0466
1.02
0.997
3.77e-08
NA
0.0235
0.309
0.513
0.00878
0.322
1.05
0.997
1.65e-08
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
 8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
BT-549 WYE-125132 3 72
sigmoid
sigmoid
BT549 WYE-132 0 3 72
 8 1.662
0.0271
0.0265
0.567
0.0245
0.0525
1.1
0.992
5.72e-07
NA
0.0574
0.33
0.592
0.0203
0.345
1.13
0.991
6.54e-07
NA
BT-549 Dactolisib 2 72
sigmoid
sigmoid
BT549 dactolisib 0 2 72
 8 1.889
0.00968
-0.00862
0.677
0.00884
0.0542
1.27
0.985
3.3e-06
NA
0.0134
0.266
0.48
0.00701
0.305
1.45
0.988
1.53e-06
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
BT-549 Torin1 1 72
sigmoid
sigmoid
BT549 Torin1 0 1 72
 8 1.794
0.017
0.0603
0.621
0.0151
0.056
0.976
0.998
7.25e-09
NA
0.0333
0.32
0.532
0.0118
0.316
0.966
0.998
9.27e-09
NA
BT-549 Torin1 2 72
sigmoid
sigmoid
BT549 Torin1 0 2 72
 8 1.881
0.0165
0.0298
0.618
0.0147
0.0572
1.03
0.993
4.2e-07
NA
0.0262
0.287
0.52
0.0111
0.306
1.1
0.99
9.68e-07
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
BT-549 PI103 1 72
sigmoid
sigmoid
BT549 PI-103 0 1 72
 8 1.795
0.206
0.0898
0.34
0.185
0.0628
1.25
0.997
2.96e-08
NA
0.348
0.336
0.737
0.155
0.318
1.25
0.996
8.76e-08
NA
HCC38 Torin1 2 72
sigmoid
sigmoid
HCC38 Torin1 0 2 72
 8 2.136
0.0241
0.0393
0.573
0.0203
0.0651
0.82
0.995
1.24e-07
NA
0.0309
0.247
0.512
0.013
0.267
0.88
0.996
4.87e-08
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
BT-20 WYE-125132 2 72
sigmoid
sigmoid
BT20 WYE-132 0 2 72
 8 2.053
0.012
0.142
0.633
0.00936
0.072
0.621
0.909
0.000752
NA
0.0232
0.316
0.475
0.00613
0.255
0.536
0.894
0.00119
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
BT-549 WYE-125132 2 72
sigmoid
sigmoid
BT549 WYE-132 0 2 72
 8 1.780
0.0329
0.0784
0.528
0.0287
0.0811
1.29
0.988
1.59e-06
NA
0.0545
0.333
0.604
0.0236
0.337
1.34
0.986
2.87e-06
NA
HCC38 Pictilisib 3 72
sigmoid
sigmoid
HCC38 pictilisib 0 3 72
 8 1.420
3.12
0.499
0.129
2.45
0.0818
0.738
0.976
1.33e-05
NA
20.5
0.664
0.911
2.24
0.401
0.731
0.974
1.7e-05
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
HCC38 ZSTK474 2 72
sigmoid
sigmoid
HCC38 ZSTK474 0 2 72
 8 2.253
1.63
0.396
0.196
2.18
-0.0865
0.554
0.984
4.3e-06
NA
2.0
0.445
0.803
1.14
0.135
0.556
0.982
5.91e-06
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA