Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	WYE-125132	1	72	sigmoid	sigmoid	HCC70 WYE-132 0 1 72	8	1.382	0.0518	0.346	0.418	0.0175	0.348	1.1	0.985	3.58e-06	NA	Inf	0.579	0.727	0.0165	0.579	1.09	0.983	4.63e-06	NA
HCC38	AZD8055	1	72	sigmoid	sigmoid	HCC38 AZD8055 0 1 72	8	1.773	0.052	0.151	0.479	0.0381	0.136	1.02	0.992	4.28e-07	NA	0.116	0.375	0.633	0.0313	0.363	0.987	0.993	3.89e-07	NA
Hs 578T	AZD8055	2		sigmoid	sigmoid	Hs578T AZD8055 2	8	2.480	0.0521	0.149	0.469	0.0387	0.142	1.13	0.999	3.49e-10	NA	0.0495	0.253	0.557	0.0273	0.249	1.16	0.999	4.45e-10	NA
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
BT-20	AZD8055	1	72	sigmoid	sigmoid	BT20 AZD8055 0 1 72	8	2.117	0.0548	0.243	0.465	0.0266	0.213	0.768	0.984	4.08e-06	NA	0.0937	0.365	0.589	0.0198	0.335	0.713	0.982	5.4e-06	NA
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
HCC38	WYE-125132	2	72	sigmoid	sigmoid	HCC38 WYE-132 0 2 72	8	2.143	0.0568	0.149	0.473	0.0413	0.124	0.896	0.998	9.66e-09	NA	0.078	0.305	0.587	0.0297	0.285	0.875	0.997	1.58e-08	NA
HCC1806	Torin2	1	72	sigmoid	sigmoid	HCC1806 Torin2 0 1 72	8	2.759	0.0569	-0.203	0.582	0.0763	-0.234	1.3	0.996	6.76e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.09e-07	NA
HCC1806	Torin2	2	72	sigmoid	sigmoid	HCC1806 Torin2 0 2 72	8	2.843	0.0589	-0.181	0.57	0.0771	-0.211	1.3	0.996	6.72e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.08e-07	NA
HCC38	WYE-125132	1	72	sigmoid	sigmoid	HCC38 WYE-132 0 1 72	8	1.708	0.0604	0.142	0.447	0.0481	0.134	1.36	0.997	3.43e-08	NA	0.115	0.384	0.669	0.0413	0.381	1.4	0.996	6.46e-08	NA
HCC38	AZD8055	2	72	sigmoid	sigmoid	HCC38 AZD8055 0 2 72	8	2.128	0.0616	0.16	0.467	0.045	0.124	0.912	0.993	3.13e-07	NA	0.0875	0.314	0.594	0.0332	0.284	0.869	0.991	6.5e-07	NA
HCC1806	Torin2	3	72	sigmoid	sigmoid	HCC1806 Torin2 0 3 72	8	3.212	0.0678	-0.0927	0.522	0.0798	-0.12	1.32	0.996	6.56e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.09e-07	NA
HCC70	Torin2	3	72	sigmoid	sigmoid	HCC70 Torin2 0 3 72	8	2.425	0.076	-0.384	0.567	0.532	-0.933	0.541	0.988	1.88e-06	NA	0.0694	0.0576	0.51	0.0694	0.0	0.61	0.973	2.02e-05	NA
HCC70	Dactolisib	1	72	sigmoid	sigmoid	HCC70 dactolisib 0 1 72	8	1.400	0.0808	-0.0667	0.501	3.34	-1.0	0.295	0.963	5.02e-05	NA	0.753	0.344	0.673	0.753	0.0	0.308	0.962	5.37e-05	NA
BT-20	WYE-125132	1	72	sigmoid	sigmoid	BT20 WYE-132 0 1 72	8	2.067	0.0893	0.289	0.402	0.0435	0.256	1.0	0.987	2.28e-06	NA	0.154	0.403	0.647	0.0353	0.375	0.941	0.985	3.56e-06	NA
BT-20	GDC-0980	1	72	sigmoid	sigmoid	BT20 apitolisib 0 1 72	8	2.001	0.0935	-0.289	0.498	0.128	-0.251	1.29	0.994	2.71e-07	NA	0.113	0.126	0.62	0.0885	0.151	1.48	0.996	7.34e-08	NA
BT-20	GDC-0980	3	72	sigmoid	sigmoid	BT20 apitolisib 0 3 72	8	2.502	0.0976	-0.115	0.437	0.107	-0.0716	1.53	0.994	2.41e-07	NA	0.0894	0.13	0.62	0.0732	0.163	1.96	0.996	6.83e-08	NA
HCC70	AZD-6482	1	72	sigmoid	sigmoid	HCC70 AZD6482 0 1 72	8	1.368	0.0982	0.0128	0.462	0.205	-0.212	0.481	0.975	1.49e-05	NA	0.767	0.394	0.704	0.121	0.305	0.509	0.973	1.9e-05	NA
HCC1806	Omipalisib	1	72	sigmoid	sigmoid	HCC1806 omipalisib 0 1 72	8	2.764	0.104	-0.333	0.49	0.508	-0.746	0.577	0.98	8.23e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC70	Torin1	2	72	sigmoid	sigmoid	HCC70 Torin1 0 2 72	8	1.726	0.107	0.323	0.391	0.0276	0.322	0.762	0.997	2.34e-08	NA	3.98	0.49	0.694	0.0225	0.491	0.775	0.997	1.93e-08	NA
HCC1806	Omipalisib	2	72	sigmoid	sigmoid	HCC1806 omipalisib 0 2 72	8	2.849	0.112	-0.311	0.479	0.543	-0.739	0.573	0.98	8.07e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
Hs 578T	GDC-0980	1		sigmoid	sigmoid	Hs578T apitolisib 1	8	1.984	0.119	-0.0587	0.419	0.141	-0.0865	0.957	0.997	3.35e-08	NA	0.161	0.224	0.662	0.0914	0.223	1.04	0.997	2.87e-08	NA
Hs 578T	PI103	1		sigmoid	sigmoid	Hs578T PI-103 1	8	2.062	0.131	-0.0743	0.433	0.182	-0.173	0.898	0.996	4.43e-08	NA	0.175	0.204	0.643	0.117	0.152	0.898	0.995	1.02e-07	NA
HCC1806	Dactolisib	1	72	sigmoid	sigmoid	HCC1806 dactolisib 0 1 72	8	2.743	0.135	-0.0744	0.444	0.391	-0.425	0.577	0.986	2.81e-06	NA	0.0977	0.121	0.559	0.093	0.0151	0.619	0.986	2.47e-06	NA
HCC1806	Dactolisib	2	72	sigmoid	sigmoid	HCC1806 dactolisib 0 2 72	8	2.828	0.145	-0.0528	0.433	0.401	-0.401	0.578	0.986	2.83e-06	NA	0.0977	0.121	0.559	0.0929	0.0151	0.619	0.986	2.47e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)