Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Torin1	3	72	sigmoid	sigmoid	BT20 Torin1 0 3 72	8	2.569	0.0237	0.0343	0.572	0.0199	0.0736	0.899	0.993	2.77e-07	NA	0.0208	0.184	0.46	0.0119	0.204	0.944	0.997	2.51e-08	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
Hs 578T	Omipalisib	3		sigmoid	sigmoid	Hs578T omipalisib 3	8	2.869	0.0255	-0.107	0.615	0.0533	-0.22	0.494	0.99	8.79e-07	NA	0.0145	0.0989	0.392	0.0102	0.0968	0.62	0.993	3.4e-07	NA
BT-549	WYE-125132	3	72	sigmoid	sigmoid	BT549 WYE-132 0 3 72	8	1.662	0.0271	0.0265	0.567	0.0245	0.0525	1.1	0.992	5.72e-07	NA	0.0574	0.33	0.592	0.0203	0.345	1.13	0.991	6.54e-07	NA
Hs 578T	Torin2	3		sigmoid	sigmoid	Hs578T Torin2 3	8	2.844	0.0272	-0.327	0.667	0.144	-0.614	0.48	0.994	2.62e-07	NA	0.0164	0.0451	0.381	0.0148	0.0308	0.638	0.995	1.07e-07	NA
HCC38	Torin1	1	72	sigmoid	sigmoid	HCC38 Torin1 0 1 72	8	1.688	0.0287	-0.0113	0.569	0.0278	0.013	0.843	0.993	4.14e-07	NA	0.0653	0.304	0.585	0.0204	0.325	0.9	0.992	4.53e-07	NA
HCC70	Torin2	1	72	sigmoid	sigmoid	HCC70 Torin2 0 1 72	8	1.364	0.0288	-0.732	0.772	0.183	-1.0	0.594	0.991	6.58e-07	NA	0.088	0.0644	0.539	0.088	0.0	0.622	0.988	1.95e-06	NA
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
Hs 578T	Torin1	3		sigmoid	sigmoid	Hs578T Torin1 3	8	2.860	0.0307	0.174	0.514	0.0196	0.176	0.964	0.999	2.01e-09	NA	0.0212	0.218	0.469	0.0119	0.222	1.02	0.998	1.17e-08	NA
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
Hs 578T	WYE-125132	1		sigmoid	sigmoid	Hs578T WYE-132 1	8	2.015	0.0322	0.0601	0.551	0.0286	0.0544	0.962	0.998	4.17e-09	NA	0.0469	0.278	0.55	0.0207	0.275	0.978	0.999	2.33e-09	NA
BT-549	WYE-125132	2	72	sigmoid	sigmoid	BT549 WYE-132 0 2 72	8	1.780	0.0329	0.0784	0.528	0.0287	0.0811	1.29	0.988	1.59e-06	NA	0.0545	0.333	0.604	0.0236	0.337	1.34	0.986	2.87e-06	NA
HCC70	Torin2	2	72	sigmoid	sigmoid	HCC70 Torin2 0 2 72	8	1.826	0.0342	-0.522	0.671	0.401	-1.0	0.446	0.979	9.23e-06	NA	0.0639	0.0733	0.507	0.0639	0.0	0.462	0.969	2.98e-05	NA
BT-20	AZD8055	3	72	sigmoid	sigmoid	BT20 AZD8055 0 3 72	8	2.694	0.0351	0.345	0.472	0.0116	0.313	0.89	0.934	0.000286	NA	0.0291	0.343	0.506	0.00813	0.306	0.743	0.922	0.000471	NA
BT-549	AZD8055	2	72	sigmoid	sigmoid	BT549 AZD8055 0 2 72	8	1.848	0.0373	0.14	0.506	0.0287	0.138	1.23	0.994	2.1e-07	NA	0.0653	0.354	0.605	0.0239	0.35	1.2	0.995	1.39e-07	NA
Hs 578T	WYE-125132	2		sigmoid	sigmoid	Hs578T WYE-132 2	8	2.544	0.0374	0.152	0.505	0.0268	0.147	1.04	0.999	8.81e-10	NA	0.0344	0.246	0.516	0.0183	0.239	1.03	0.999	2.53e-09	NA
BT-20	Torin1	1	72	sigmoid	sigmoid	BT20 Torin1 0 1 72	8	2.022	0.0383	-0.105	0.566	0.0658	-0.179	0.565	0.991	7.45e-07	NA	0.0591	0.197	0.536	0.0286	0.182	0.624	0.994	2.54e-07	NA
Hs 578T	AZD8055	1		sigmoid	sigmoid	Hs578T AZD8055 1	8	2.009	0.0391	0.073	0.531	0.0347	0.0546	0.975	0.995	1.39e-07	NA	0.0591	0.286	0.565	0.0259	0.27	0.941	0.994	1.73e-07	NA
HCC38	Omipalisib	2	72	sigmoid	sigmoid	HCC38 omipalisib 0 2 72	8	2.124	0.0404	-0.47	0.634	0.45	-1.0	0.456	0.979	9.71e-06	NA	0.0507	0.0595	0.494	0.0507	0.0	0.556	0.96	6.44e-05	NA
BT-20	GDC-0980	2	72	sigmoid	sigmoid	BT20 apitolisib 0 2 72	8	1.659	0.0456	-0.414	0.639	0.0629	-0.33	1.58	0.993	4.18e-07	NA	0.0641	0.131	0.575	0.0506	0.168	1.74	0.995	1.2e-07	NA
HCC38	AZD8055	3	72	sigmoid	sigmoid	HCC38 AZD8055 0 3 72	8	1.417	0.0464	0.0327	0.53	0.0463	0.000983	1.04	0.997	4.27e-08	NA	0.157	0.392	0.658	0.041	0.372	1.02	0.996	5.78e-08	NA
HCC70	Torin1	1	72	sigmoid	sigmoid	HCC70 Torin1 0 1 72	8	1.345	0.0472	0.15	0.487	0.0311	0.149	0.849	0.973	1.89e-05	NA	0.93	0.475	0.693	0.0276	0.475	0.854	0.973	2.05e-05	NA
HCC70	AZD8055	1	72	sigmoid	sigmoid	HCC70 AZD8055 0 1 72	8	1.339	0.0485	0.242	0.442	0.0243	0.26	1.06	0.976	1.32e-05	NA	Inf	0.529	0.721	0.0222	0.54	1.08	0.974	1.81e-05	NA
HCC38	WYE-125132	3	72	sigmoid	sigmoid	HCC38 WYE-132 0 3 72	8	1.449	0.0494	-0.0216	0.518	0.0504	-0.0117	1.18	0.998	9.69e-09	NA	0.128	0.355	0.662	0.0441	0.361	1.2	0.998	9.53e-09	NA
BT-20	WYE-125132	3	72	sigmoid	sigmoid	BT20 WYE-132 0 3 72	8	2.654	0.0504	0.282	0.465	0.0254	0.236	0.929	0.922	0.000468	NA	0.048	0.307	0.526	0.0182	0.246	0.698	0.918	0.000553	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)