Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC38	Dactolisib	2	72	sigmoid	sigmoid	HCC38 dactolisib 0 2 72	8	2.120	0.0118	-0.0557	0.668	0.0118	-0.00134	0.785	0.98	7.61e-06	NA	0.0145	0.204	0.447	0.00701	0.245	0.927	0.988	1.88e-06	NA
BT-20	WYE-125132	2	72	sigmoid	sigmoid	BT20 WYE-132 0 2 72	8	2.053	0.012	0.142	0.633	0.00936	0.072	0.621	0.909	0.000752	NA	0.0232	0.316	0.475	0.00613	0.255	0.536	0.894	0.00119	NA
BT-549	Torin1	3	72	sigmoid	sigmoid	BT549 Torin1 0 3 72	8	1.757	0.0123	0.026	0.659	0.0112	0.0466	1.02	0.997	3.77e-08	NA	0.0235	0.309	0.513	0.00878	0.322	1.05	0.997	1.65e-08	NA
Hs 578T	Trametinib	3		sigmoid	sigmoid	Hs578T trametinib 3	8	2.830	0.0128	0.0657	0.644	0.0112	0.0447	0.702	0.998	4.02e-09	NA	0.00864	0.168	0.366	0.00512	0.157	0.722	0.998	5.57e-09	NA
Hs 578T	Dactolisib	2		sigmoid	sigmoid	Hs578T dactolisib 2	8	2.509	0.0128	-0.0617	0.655	0.0126	0.00741	0.79	0.974	1.78e-05	NA	0.0105	0.15	0.405	0.00638	0.203	1.04	0.985	3.67e-06	NA
HCC38	Torin2	3	72	sigmoid	sigmoid	HCC38 Torin2 0 3 72	8	1.385	0.013	-0.624	0.855	0.0547	-0.706	0.615	0.996	8.13e-08	NA	0.0407	0.0986	0.484	0.0311	0.0829	0.669	0.997	3.31e-08	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
HCC38	Omipalisib	3	72	sigmoid	sigmoid	HCC38 omipalisib 0 3 72	8	1.446	0.0145	-0.503	0.802	0.0539	-0.597	0.6	0.993	3.08e-07	NA	0.0449	0.134	0.499	0.0308	0.107	0.644	0.993	2.98e-07	NA
HCC38	Torin2	2	72	sigmoid	sigmoid	HCC38 Torin2 0 2 72	8	2.140	0.0146	-0.48	0.793	0.0654	-0.634	0.545	0.993	3.78e-07	NA	0.0176	0.056	0.391	0.015	0.0502	0.68	0.989	1.33e-06	NA
Hs 578T	Torin2	1		sigmoid	sigmoid	Hs578T Torin2 1	8	2.031	0.015	-0.405	0.761	0.0631	-0.56	0.522	0.992	5.31e-07	NA	0.021	0.0851	0.419	0.0163	0.0756	0.64	0.993	3.63e-07	NA
HCC70	Trametinib	1	72	sigmoid	sigmoid	HCC70 trametinib 0 1 72	8	1.421	0.015	0.339	0.521	0.00411	0.34	0.879	0.966	4.1e-05	NA	Inf	0.566	0.653	0.00373	0.566	0.875	0.968	3.23e-05	NA
Hs 578T	Torin2	2		sigmoid	sigmoid	Hs578T Torin2 2	8	2.528	0.0153	-0.467	0.778	0.112	-0.771	0.47	0.986	2.55e-06	NA	0.0122	0.0353	0.352	0.0109	0.036	0.668	0.984	4.09e-06	NA
Hs 578T	Omipalisib	2		sigmoid	sigmoid	Hs578T omipalisib 2	8	2.507	0.0155	-0.52	0.766	0.239	-1.0	0.402	0.993	3.45e-07	NA	0.0114	0.028	0.355	0.0114	0.0	0.468	0.981	6.9e-06	NA
HCC70	Omipalisib	3	72	sigmoid	sigmoid	HCC70 omipalisib 0 3 72	8	2.458	0.0158	-0.404	0.771	0.0319	-0.379	0.8	0.99	8.95e-07	NA	0.0148	0.051	0.376	0.0127	0.0733	1.02	0.996	4.59e-08	NA
BT-549	Omipalisib	1	72	sigmoid	sigmoid	BT549 omipalisib 0 1 72	8	1.789	0.0164	-0.2	0.693	0.0219	-0.149	0.887	0.986	2.66e-06	NA	0.0272	0.194	0.495	0.0148	0.228	0.993	0.991	8.42e-07	NA
BT-549	Torin1	2	72	sigmoid	sigmoid	BT549 Torin1 0 2 72	8	1.881	0.0165	0.0298	0.618	0.0147	0.0572	1.03	0.993	4.2e-07	NA	0.0262	0.287	0.52	0.0111	0.306	1.1	0.99	9.68e-07	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
BT-20	Torin2	1	72	sigmoid	sigmoid	BT20 Torin2 0 1 72	8	2.018	0.0185	-0.739	0.803	0.158	-1.0	0.511	0.986	2.9e-06	NA	0.0245	0.0164	0.415	0.0245	0.0	0.616	0.99	1.06e-06	NA
BT-20	Torin2	3	72	sigmoid	sigmoid	BT20 Torin2 0 3 72	8	2.458	0.019	-0.64	0.751	0.234	-1.0	0.438	0.959	6.92e-05	NA	0.0147	0.0148	0.379	0.0123	0.0598	0.727	0.977	1.28e-05	NA
Hs 578T	Torin1	2		sigmoid	sigmoid	Hs578T Torin1 2	8	2.548	0.0205	0.144	0.566	0.0148	0.14	1.0	0.999	3.13e-10	NA	0.0182	0.241	0.463	0.00975	0.24	1.04	0.999	6.11e-10	NA
Hs 578T	Torin1	1		sigmoid	sigmoid	Hs578T Torin1 1	8	1.956	0.0217	0.0183	0.598	0.0203	0.0286	0.911	0.994	1.81e-07	NA	0.0321	0.267	0.524	0.0141	0.28	0.995	0.996	8.78e-08	NA
BT-20	Dactolisib	1	72	sigmoid	sigmoid	BT20 dactolisib 0 1 72	8	2.055	0.0223	-0.205	0.652	0.0609	-0.33	0.505	0.979	9.18e-06	NA	0.0305	0.15	0.475	0.0171	0.153	0.631	0.979	9.75e-06	NA
HCC38	Omipalisib	1	72	sigmoid	sigmoid	HCC38 omipalisib 0 1 72	8	1.760	0.0231	-0.316	0.672	0.152	-0.638	0.438	0.97	2.61e-05	NA	0.0585	0.151	0.512	0.0499	0.0356	0.465	0.956	8.65e-05	NA
HCC38	Torin1	3	72	sigmoid	sigmoid	HCC38 Torin1 0 3 72	8	1.441	0.0231	-0.202	0.666	0.0412	-0.248	0.698	0.999	5.79e-10	NA	0.0787	0.266	0.572	0.0306	0.245	0.714	0.999	5.55e-10	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)