Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 CAL-101 1 72
sigmoid
sigmoid
BT549 idelalisib 0 1 72
 8 1.791
Inf
0.836
0.041
4.8
0.605
0.778
0.924
0.00044
NA
Inf
0.858
0.964
4.79
0.659
0.767
0.92
0.000518
NA
BT-549 Alpelisib 3 72
flat
flat
BT549 alpelisib 0 3 72
 8 1.743
Inf
0.817
0.068
0.0
0.817
0.01
-0.0192
1.0
0.915
Inf
0.846
0.942
0.0
0.846
0.01
-0.0162
1.0
0.928
BT-549 Alpelisib 2 72
sigmoid
sigmoid
BT549 alpelisib 0 2 72
 8 1.927
Inf
0.832
0.0409
4.24
0.663
0.548
0.706
0.0254
NA
Inf
0.844
0.962
4.26
0.686
0.542
0.696
0.0282
NA
BT-549 Alpelisib 1 72
flat
flat
BT549 alpelisib 0 1 72
 8 1.822
Inf
0.747
0.0781
0.0
0.747
0.01
0.439
0.176
0.914
Inf
0.782
0.931
0.0
0.782
0.01
0.415
0.2
0.925
HCC1806 Trametinib 1 72
sigmoid
sigmoid
HCC1806 trametinib 0 1 72
 8 2.751
Inf
0.795
0.139
0.00972
0.802
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 2 72
sigmoid
sigmoid
HCC1806 trametinib 0 2 72
 8 2.836
Inf
0.8
0.135
0.00973
0.808
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC1806 Trametinib 3 72
sigmoid
sigmoid
HCC1806 trametinib 0 3 72
 8 3.204
Inf
0.822
0.12
0.00981
0.829
0.872
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA