Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
 8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA
HCC38 AS605240 2 72
sigmoid
sigmoid
HCC38 AS-605240 0 2 72
 8 2.200
17.4
0.642
0.114
4.07
0.256
0.493
0.936
0.000265
NA
46.2
0.648
0.882
1.68
0.411
0.522
0.929
0.000356
NA
BT-549 TGX221 2 72
sigmoid
sigmoid
BT549 TGX-221 0 2 72
 8 1.927
17.5
0.772
0.0551
123.0
-1.0
0.562
0.907
0.000795
NA
32.3
0.792
0.949
32.3
3.45e-05
0.58
0.899
0.00102
NA
HCC70 TGX221 2 72
sigmoid
sigmoid
HCC70 TGX-221 0 2 72
 8 1.786
1.77
0.467
0.233
0.531
0.227
0.503
0.948
0.000139
NA
5.85
0.575
0.806
3.44
0.0897
0.372
0.937
0.000249
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
Hs 578T AS605240 2
sigmoid
sigmoid
Hs578T AS-605240 2
 8 2.547
1.89
0.43
0.194
1.81
0.011
0.541
0.988
1.81e-06
NA
1.6
0.426
0.784
0.971
0.117
0.532
0.983
4.67e-06
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
HCC38 MK2206 1 72
sigmoid
sigmoid
HCC38 MK-2206 0 1 72
 8 1.789
19.4
0.698
0.0995
320.0
-0.949
0.38
0.956
8.33e-05
NA
61.8
0.746
0.914
61.8
0.0
0.386
0.951
0.000115
NA
BT-549 PIK-93 3 72
sigmoid
sigmoid
BT549 PIK-93 0 3 72
 8 1.807
20.1
0.719
0.0848
231.0
-1.0
0.45
0.716
0.0229
NA
67.9
0.761
0.925
67.9
0.0
0.431
0.686
0.0309
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
BT-549 Pictilisib 1 72
sigmoid
sigmoid
BT549 pictilisib 0 1 72
 8 1.772
2.08
0.415
0.117
1.42
0.154
0.959
0.987
2.26e-06
NA
5.12
0.541
0.904
1.06
0.396
0.995
0.985
3.49e-06
NA
HCC70 PIK-93 3 72
sigmoid
sigmoid
HCC70 PIK-93 0 3 72
 8 2.519
21.2
0.756
0.0663
181.0
-1.0
0.513
0.851
0.00333
NA
34.1
0.721
0.92
34.1
0.0
0.473
0.831
0.00487
NA
Hs 578T Alpelisib 1
sigmoid
sigmoid
Hs578T alpelisib 1
 8 2.097
2.3
0.449
0.205
42.0
-1.0
0.378
0.954
9.56e-05
NA
3.9
0.508
0.803
3.9
0.0
0.401
0.94
0.000216
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
Hs 578T PIK-93 3
sigmoid
sigmoid
Hs578T PIK-93 3
 8 2.816
2.36
0.412
0.0884
2.23
0.033
1.2
0.994
1.87e-07
NA
1.89
0.375
0.897
1.42
0.149
1.24
0.991
8.33e-07
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
BT-549 AZD-6482 1 72
sigmoid
sigmoid
BT549 AZD6482 0 1 72
 8 1.798
27.5
0.671
0.115
4.1
0.299
0.478
0.992
4.23e-07
NA
164.0
0.723
0.901
4.18
0.408
0.461
0.992
5.34e-07
NA
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA