Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
HCC70	Torin1	1	72	sigmoid	sigmoid	HCC70 Torin1 0 1 72	8	1.345	0.0472	0.15	0.487	0.0311	0.149	0.849	0.973	1.89e-05	NA	0.93	0.475	0.693	0.0276	0.475	0.854	0.973	2.05e-05	NA
HCC70	Omipalisib	3	72	sigmoid	sigmoid	HCC70 omipalisib 0 3 72	8	2.458	0.0158	-0.404	0.771	0.0319	-0.379	0.8	0.99	8.95e-07	NA	0.0148	0.051	0.376	0.0127	0.0733	1.02	0.996	4.59e-08	NA
HCC70	AZD8055	2	72	sigmoid	sigmoid	HCC70 AZD8055 0 2 72	8	1.724	0.17	0.404	0.346	0.0331	0.385	0.897	0.996	7.36e-08	NA	Inf	0.543	0.728	0.0284	0.531	0.905	0.996	6.22e-08	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
Hs 578T	AZD8055	1		sigmoid	sigmoid	Hs578T AZD8055 1	8	2.009	0.0391	0.073	0.531	0.0347	0.0546	0.975	0.995	1.39e-07	NA	0.0591	0.286	0.565	0.0259	0.27	0.941	0.994	1.73e-07	NA
HCC70	Torin1	3	72	sigmoid	sigmoid	HCC70 Torin1 0 3 72	8	2.415	3.74	0.495	0.279	0.0352	0.496	1.02	0.994	2.6e-07	NA	5.73	0.495	0.709	0.0284	0.498	1.06	0.994	2.26e-07	NA
HCC38	AZD8055	1	72	sigmoid	sigmoid	HCC38 AZD8055 0 1 72	8	1.773	0.052	0.151	0.479	0.0381	0.136	1.02	0.992	4.28e-07	NA	0.116	0.375	0.633	0.0313	0.363	0.987	0.993	3.89e-07	NA
Hs 578T	AZD8055	2		sigmoid	sigmoid	Hs578T AZD8055 2	8	2.480	0.0521	0.149	0.469	0.0387	0.142	1.13	0.999	3.49e-10	NA	0.0495	0.253	0.557	0.0273	0.249	1.16	0.999	4.45e-10	NA
HCC38	Torin1	3	72	sigmoid	sigmoid	HCC38 Torin1 0 3 72	8	1.441	0.0231	-0.202	0.666	0.0412	-0.248	0.698	0.999	5.79e-10	NA	0.0787	0.266	0.572	0.0306	0.245	0.714	0.999	5.55e-10	NA
HCC38	WYE-125132	2	72	sigmoid	sigmoid	HCC38 WYE-132 0 2 72	8	2.143	0.0568	0.149	0.473	0.0413	0.124	0.896	0.998	9.66e-09	NA	0.078	0.305	0.587	0.0297	0.285	0.875	0.997	1.58e-08	NA
BT-20	WYE-125132	1	72	sigmoid	sigmoid	BT20 WYE-132 0 1 72	8	2.067	0.0893	0.289	0.402	0.0435	0.256	1.0	0.987	2.28e-06	NA	0.154	0.403	0.647	0.0353	0.375	0.941	0.985	3.56e-06	NA
BT-20	Omipalisib	3	72	sigmoid	sigmoid	BT20 omipalisib 0 3 72	8	2.586	0.00689	-0.587	0.893	0.044	-0.714	0.478	0.958	7.32e-05	NA	0.00572	0.017	0.281	0.00491	0.0669	0.945	0.983	4.7e-06	NA
HCC1806	WYE-125132	1	72	sigmoid	sigmoid	HCC1806 WYE-132 0 1 72	8	2.790	0.603	0.466	0.292	0.0448	0.45	0.883	0.997	3.72e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC1806	WYE-125132	2	72	sigmoid	sigmoid	HCC1806 WYE-132 0 2 72	8	2.874	0.872	0.479	0.284	0.045	0.464	0.883	0.997	3.66e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC38	AZD8055	2	72	sigmoid	sigmoid	HCC38 AZD8055 0 2 72	8	2.128	0.0616	0.16	0.467	0.045	0.124	0.912	0.993	3.13e-07	NA	0.0875	0.314	0.594	0.0332	0.284	0.869	0.991	6.5e-07	NA
HCC1806	WYE-125132	3	72	sigmoid	sigmoid	HCC1806 WYE-132 0 3 72	8	3.242	Inf	0.531	0.255	0.0458	0.517	0.885	0.997	3.48e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC38	AZD8055	3	72	sigmoid	sigmoid	HCC38 AZD8055 0 3 72	8	1.417	0.0464	0.0327	0.53	0.0463	0.000983	1.04	0.997	4.27e-08	NA	0.157	0.392	0.658	0.041	0.372	1.02	0.996	5.78e-08	NA
HCC38	WYE-125132	1	72	sigmoid	sigmoid	HCC38 WYE-132 0 1 72	8	1.708	0.0604	0.142	0.447	0.0481	0.134	1.36	0.997	3.43e-08	NA	0.115	0.384	0.669	0.0413	0.381	1.4	0.996	6.46e-08	NA
BT-20	Torin2	2	72	sigmoid	sigmoid	BT20 Torin2 0 2 72	8	1.733	0.00315	-0.761	0.992	0.0484	-0.95	0.389	0.949	0.000131	NA	0.00804	0.0252	0.336	0.00642	0.0613	0.583	0.974	1.77e-05	NA
HCC38	WYE-125132	3	72	sigmoid	sigmoid	HCC38 WYE-132 0 3 72	8	1.449	0.0494	-0.0216	0.518	0.0504	-0.0117	1.18	0.998	9.69e-09	NA	0.128	0.355	0.662	0.0441	0.361	1.2	0.998	9.53e-09	NA
HCC1806	AZD8055	1	72	sigmoid	sigmoid	HCC1806 AZD8055 0 1 72	8	2.732	Inf	0.534	0.247	0.0515	0.522	1.19	0.995	1.3e-07	NA	0.521	0.484	0.716	0.0427	0.471	1.15	0.996	7.15e-08	NA
HCC1806	AZD8055	2	72	sigmoid	sigmoid	HCC1806 AZD8055 0 2 72	8	2.817	Inf	0.546	0.24	0.0517	0.535	1.19	0.995	1.31e-07	NA	0.521	0.484	0.716	0.0427	0.471	1.15	0.996	7.15e-08	NA
HCC1806	AZD8055	3	72	sigmoid	sigmoid	HCC1806 AZD8055 0 3 72	8	3.185	Inf	0.593	0.215	0.0523	0.583	1.19	0.995	1.36e-07	NA	0.521	0.484	0.716	0.0427	0.471	1.15	0.996	7.15e-08	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)