Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	TGX221	1	72	flat	flat	BT20 TGX-221 0 1 72	8	1.988	Inf	1.02	-0.00357	1.02	0.01	-0.00762	1.0	1.0	Inf	1.02	1.0	1.02	0.01	-0.00881	1.0	1.0
BT-20	TGX221	2	72	flat	flat	BT20 TGX-221 0 2 72	8	1.656	Inf	1.0	0.0477	1.0	0.01	-0.101	1.0	0.946	Inf	1.0	0.961	1.0	0.01	-0.101	1.0	0.956
BT-20	TGX221	3	72	flat	flat	BT20 TGX-221 0 3 72	8	2.469	Inf	1.01	0.0147	1.01	0.01	-0.0563	1.0	0.982	Inf	1.01	0.983	1.01	0.01	-0.0552	1.0	0.979
BT-20	Everolimus	3	72	flat	flat	BT20 everolimus 0 3 72	8	2.422	Inf	0.475	0.456	0.475	0.01	0.602	0.0632	0.543	Inf	0.478	0.534	0.478	0.01	0.561	0.0844	0.534
HCC70	KIN001-244	1	72	flat	flat	HCC70 KIN001-244 0 1 72	8	1.350	Inf	0.889	0.00722	0.889	0.01	0.616	0.0568	0.988	Inf	0.926	0.995	0.926	0.01	0.612	0.0584	0.992
HCC38	Alpelisib	2	72	flat	flat	HCC38 alpelisib 0 2 72	8	2.086	Inf	0.848	0.0559	0.848	0.01	-0.0371	1.0	0.931	Inf	0.848	0.944	0.848	0.01	-0.0359	1.0	0.932
HCC70	Everolimus	2	72	flat	flat	HCC70 everolimus 0 2 72	8	1.730	Inf	0.674	0.227	0.674	0.01	0.271	0.388	0.766	Inf	0.735	0.812	0.735	0.01	0.264	0.399	0.807
HCC38	AS605240	3	72	flat	flat	HCC38 AS-605240 0 3 72	8	1.343	Inf	0.958	-0.0162	0.958	0.01	-0.233	1.0	1.01	Inf	0.972	1.01	0.972	0.01	-0.235	1.0	1.01
BT-549	XL147	2	72	flat	flat	BT549 pilaralisib 0 2 72	8	1.952	Inf	0.967	-0.00824	0.967	0.01	-0.000427	1.0	1.0	Inf	0.968	1.01	0.968	0.01	-0.000878	1.0	1.0
BT-20	KIN001-244	1	72	flat	flat	BT20 KIN001-244 0 1 72	8	2.125	Inf	0.911	0.0401	0.911	0.01	-0.00641	1.0	0.957	Inf	0.908	0.958	0.908	0.01	-0.00745	1.0	0.955
HCC70	Alpelisib	3	72	flat	flat	HCC70 alpelisib 0 3 72	8	2.465	Inf	0.859	0.027	0.859	0.01	0.407	0.209	0.961	Inf	0.835	0.968	0.835	0.01	0.394	0.222	0.954
BT-549	XL147	3	72	flat	flat	BT549 pilaralisib 0 3 72	8	1.772	Inf	0.933	0.0351	0.933	0.01	-0.0699	1.0	0.962	Inf	0.941	0.969	0.941	0.01	-0.0712	1.0	0.967
BT-20	BX-912	1	72	flat	flat	BT20 BX-912 0 1 72	8	2.193	Inf	0.858	0.0928	0.858	0.01	0.25	0.422	0.903	Inf	0.851	0.901	0.851	0.01	0.243	0.433	0.897
HCC38	XL147	1	72	flat	flat	HCC38 pilaralisib 0 1 72	8	1.752	Inf	0.949	0.0257	0.949	0.01	-0.0703	1.0	0.973	Inf	0.955	0.978	0.955	0.01	-0.0701	1.0	0.977
HCC38	Sirolimus	1	72	flat	flat	HCC38 rapamycin 0 1 72	8	1.723	Inf	0.531	0.429	0.531	0.01	0.623	0.0538	0.573	Inf	0.631	0.66	0.631	0.01	0.536	0.0998	0.661
BT-20	XL147	1	72	flat	flat	BT20 pilaralisib 0 1 72	8	2.128	Inf	0.815	0.048	0.815	0.01	0.411	0.205	0.939	Inf	0.813	0.95	0.813	0.01	0.383	0.234	0.937
BT-20	XL147	2	72	flat	flat	BT20 pilaralisib 0 2 72	8	1.784	Inf	0.759	0.073	0.759	0.01	-0.0058	1.0	0.907	Inf	0.796	0.937	0.796	0.01	-0.00637	1.0	0.92
BT-20	XL147	3	72	flat	flat	BT20 pilaralisib 0 3 72	8	2.647	Inf	0.755	0.102	0.755	0.01	0.0679	0.81	0.885	Inf	0.708	0.871	0.708	0.01	0.0505	0.856	0.857
BT-549	XL147	1	72	flat	flat	BT549 pilaralisib 0 1 72	8	1.855	Inf	0.941	0.0385	0.941	0.01	-0.0931	1.0	0.954	Inf	0.946	0.965	0.946	0.01	-0.0808	1.0	0.958
BT-549	Sirolimus	2	72	flat	flat	BT549 rapamycin 0 2 72	8	1.830	Inf	0.569	0.384	0.569	0.01	0.517	0.113	0.618	Inf	0.642	0.677	0.642	0.01	0.465	0.153	0.679
BT-20	BX-912	3	72	flat	flat	BT20 BX-912 0 3 72	8	2.619	Inf	0.904	0.0795	0.904	0.01	0.000173	0.999	0.918	Inf	0.879	0.9	0.879	0.01	0.00619	0.982	0.896
BT-549	Everolimus	2	72	flat	flat	BT549 everolimus 0 2 72	8	1.909	Inf	0.566	0.407	0.566	0.01	-0.646	1.0	0.594	Inf	0.627	0.648	0.627	0.01	-1.01	1.0	0.649
BT-549	AS605240	2	72	flat	flat	BT549 AS-605240 0 2 72	8	1.961	Inf	0.91	0.0479	0.91	0.01	0.414	0.201	0.949	Inf	0.914	0.954	0.914	0.01	0.418	0.197	0.951
Hs 578T	XL147	3		flat	flat	Hs578T pilaralisib 3	8	2.879	Inf	0.971	-0.00618	0.971	0.01	0.331	0.299	1.0	Inf	0.959	1.01	0.959	0.01	0.319	0.315	1.0
Hs 578T	XL147	2		flat	flat	Hs578T pilaralisib 2	8	2.509	Inf	0.976	0.000255	0.976	0.01	0.435	0.181	0.997	Inf	0.97	1.0	0.97	0.01	0.432	0.183	0.996

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)