Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
Hs 578T AZD-6482 2
sigmoid
sigmoid
Hs578T AZD6482 2
 8 2.508
6.35
0.602
0.121
74.8
-1.0
0.445
0.998
1.12e-08
NA
6.4
0.573
0.86
6.4
0.0
0.475
0.996
6.36e-08
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-20 AZD-6482 3 72
sigmoid
sigmoid
BT20 AZD6482 0 3 72
 8 2.601
1.68
0.3
0.173
8.38
-1.0
0.685
0.959
6.72e-05
NA
1.5
0.326
0.805
1.5
0.0
0.733
0.925
0.000414
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
HCC70 PIK-93 2 72
sigmoid
sigmoid
HCC70 PIK-93 0 2 72
 8 1.705
4.34
0.647
0.0132
9.3
-1.0
1.44
0.888
0.0014
NA
6.01
0.718
0.991
6.01
0.0
1.49
0.872
0.00208
NA