Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC1806	PIK-93	1	72	sigmoid	sigmoid	HCC1806 PIK-93 0 1 72	8	2.753	44.0	0.853	0.0391	304.0	-1.0	0.568	0.858	0.00285	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
HCC38	PI103	3	72	sigmoid	sigmoid	HCC38 PI-103 0 3 72	8	1.481	1.26	0.114	0.168	3.16	-0.762	1.01	0.986	2.53e-06	NA	2.34	0.42	0.884	2.34	0.0	1.03	0.983	4.94e-06	NA
HCC38	MK2206	1	72	sigmoid	sigmoid	HCC38 MK-2206 0 1 72	8	1.789	19.4	0.698	0.0995	320.0	-0.949	0.38	0.956	8.33e-05	NA	61.8	0.746	0.914	61.8	0.0	0.386	0.951	0.000115	NA
BT-20	AS605240	2	72	sigmoid	sigmoid	BT20 AS-605240 0 2 72	8	1.846	4509270.0	0.729	0.203	320.0	0.31	0.101	0.845	0.00373	NA	4.4e+12	0.764	0.821	56.5	0.46	0.101	0.843	0.00388	NA
HCC38	TGX221	3	72	sigmoid	sigmoid	HCC38 TGX-221 0 3 72	8	1.484	3688.0	0.815	0.0743	320.0	0.243	0.273	0.867	0.00233	NA	3261706.0	0.866	0.945	320.0	0.458	0.269	0.867	0.00238	NA
BT-549	CAL-101	3	72	sigmoid	sigmoid	BT549 idelalisib 0 3 72	8	1.770	43.0	0.79	0.0687	320.0	-0.664	0.421	0.862	0.00261	NA	118.0	0.822	0.941	118.0	0.0	0.425	0.854	0.00309	NA
Hs 578T	CAL-101	2		sigmoid	sigmoid	Hs578T idelalisib 2	8	2.534	57.5	0.801	0.0636	320.0	-0.507	0.408	0.979	9.58e-06	NA	Inf	0.766	0.923	4.27	0.505	0.495	0.975	1.65e-05	NA
HCC38	MK2206	3	72	sigmoid	sigmoid	HCC38 MK-2206 0 3 72	8	1.445	71.7	0.728	0.123	320.0	-0.26	0.28	0.854	0.0031	NA	Inf	0.81	0.912	4.3	0.61	0.332	0.834	0.00461	NA
HCC1806	MK2206	1	72	sigmoid	sigmoid	HCC1806 MK-2206 0 1 72	8	2.746	47.7	0.818	0.0504	320.0	-0.715	0.466	0.981	7.02e-06	NA	Inf	0.769	0.934	4.46	0.507	0.566	0.976	1.46e-05	NA
HCC1806	MK2206	2	72	sigmoid	sigmoid	HCC1806 MK-2206 0 2 72	8	2.831	51.9	0.823	0.0489	320.0	-0.668	0.467	0.981	7.01e-06	NA	Inf	0.769	0.934	4.46	0.507	0.566	0.976	1.45e-05	NA
BT-549	TGX221	3	72	sigmoid	sigmoid	BT549 TGX-221 0 3 72	8	1.768	93790.0	0.805	0.0889	320.0	0.356	0.22	0.707	0.0251	NA	49050766.0	0.834	0.923	320.0	0.461	0.214	0.703	0.0263	NA
HCC1806	MK2206	3	72	sigmoid	sigmoid	HCC1806 MK-2206 0 3 72	8	3.199	74.1	0.843	0.0434	320.0	-0.491	0.468	0.981	6.96e-06	NA	Inf	0.769	0.934	4.46	0.507	0.566	0.976	1.46e-05	NA
HCC1806	PIK-93	3	72	sigmoid	sigmoid	HCC1806 PIK-93 0 3 72	8	3.206	56.0	0.873	0.0337	320.0	-0.872	0.579	0.859	0.00279	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
BT-20	MK2206	3	72	sigmoid	sigmoid	BT20 MK-2206 0 3 72	8	2.449	1.73	0.252	0.12	3.23	-0.504	1.11	0.988	1.77e-06	NA	1.69	0.318	0.877	1.69	0.0	1.18	0.979	9.03e-06	NA
HCC70	Dactolisib	1	72	sigmoid	sigmoid	HCC70 dactolisib 0 1 72	8	1.400	0.0808	-0.0667	0.501	3.34	-1.0	0.295	0.963	5.02e-05	NA	0.753	0.344	0.673	0.753	0.0	0.308	0.962	5.37e-05	NA
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
Hs 578T	PIK-93	2		sigmoid	sigmoid	Hs578T PIK-93 2	8	2.467	2.43	0.415	0.0931	3.62	-0.243	0.991	0.991	8.05e-07	NA	2.34	0.426	0.901	1.93	0.0909	1.04	0.987	2.24e-06	NA
BT-20	AZD-6482	1	72	sigmoid	sigmoid	BT20 AZD6482 0 1 72	8	2.043	1.34	0.182	0.173	3.83	-0.782	0.893	0.982	5.6e-06	NA	1.65	0.342	0.845	1.65	0.0	0.977	0.972	2.09e-05	NA
BT-20	AZD-6482	2	72	sigmoid	sigmoid	BT20 AZD6482 0 2 72	8	1.645	0.581	0.0253	0.303	3.86	-1.0	0.58	0.904	0.000884	NA	1.34	0.333	0.772	1.34	0.0	0.582	0.864	0.0025	NA
BT-20	AS605240	1	72	sigmoid	sigmoid	BT20 AS-605240 0 1 72	8	2.142	Inf	0.817	0.0993	3.91	0.634	0.244	0.861	0.00271	NA	Inf	0.814	0.897	3.87	0.629	0.237	0.854	0.00311	NA
Hs 578T	KIN001-244	1		sigmoid	sigmoid	Hs578T KIN001-244 1	8	2.041	24.7	0.739	0.0391	4.05	0.414	0.972	0.968	3.4e-05	NA	Inf	0.752	0.962	3.15	0.51	0.99	0.964	4.65e-05	NA
HCC38	AS605240	2	72	sigmoid	sigmoid	HCC38 AS-605240 0 2 72	8	2.200	17.4	0.642	0.114	4.07	0.256	0.493	0.936	0.000265	NA	46.2	0.648	0.882	1.68	0.411	0.522	0.929	0.000356	NA
HCC38	CAL-101	3	72	sigmoid	sigmoid	HCC38 idelalisib 0 3 72	8	1.443	Inf	0.851	0.0804	4.08	0.726	0.225	0.706	0.0254	NA	Inf	0.894	0.943	4.27	0.804	0.222	0.707	0.0252	NA
BT-549	AZD-6482	1	72	sigmoid	sigmoid	BT549 AZD6482 0 1 72	8	1.798	27.5	0.671	0.115	4.1	0.299	0.478	0.992	4.23e-07	NA	164.0	0.723	0.901	4.18	0.408	0.461	0.992	5.34e-07	NA
BT-20	AS605240	3	72	sigmoid	sigmoid	BT20 AS-605240 0 3 72	8	2.607	Inf	0.845	0.0823	4.13	0.662	0.292	0.729	0.0199	NA	Inf	0.81	0.897	3.97	0.589	0.284	0.712	0.0239	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)