Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 BX-912 3 72
sigmoid
sigmoid
HCC1806 BX-912 0 3 72
 8 3.193
1.09
0.234
0.126
0.897
0.217
2.99
0.999
2.85e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC38 CAL-101 2 72
sigmoid
sigmoid
HCC38 idelalisib 0 2 72
 8 2.154
Inf
0.881
0.0205
0.901
0.879
3.37
0.892
0.00125
NA
Inf
0.876
0.979
0.891
0.874
3.37
0.887
0.00144
NA
Hs 578T TGX221 2
sigmoid
sigmoid
Hs578T TGX-221 2
 8 2.462
Inf
0.816
0.0307
0.904
0.781
1.29
0.964
4.56e-05
NA
Inf
0.789
0.964
0.834
0.754
1.3
0.96
6.63e-05
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
 8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
HCC70 CAL-101 2 72
sigmoid
sigmoid
HCC70 idelalisib 0 2 72
 8 1.738
Inf
0.62
0.0432
0.959
0.611
3.13
0.965
4.31e-05
NA
Inf
0.693
0.965
0.935
0.686
3.13
0.96
6.52e-05
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC38 Pictilisib 1 72
sigmoid
sigmoid
HCC38 pictilisib 0 1 72
 8 1.759
7.16
0.562
0.125
1.04
0.377
0.725
0.992
5.12e-07
NA
Inf
0.647
0.896
0.797
0.529
0.742
0.992
5.77e-07
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
BT-549 Buparlisib 2 72
sigmoid
sigmoid
BT549 buparlisib 0 2 72
 8 1.913
0.681
-0.306
0.217
1.08
-0.538
1.59
0.998
1.31e-08
NA
0.821
0.132
0.838
0.769
0.0514
1.66
0.996
8.95e-08
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
HCC1806 ZSTK474 2 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 2 72
 8 2.794
Inf
0.613
0.036
1.16
0.61
5.0
0.99
1.1e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
HCC1806 ZSTK474 1 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 1 72
 8 2.709
Inf
0.602
0.037
1.17
0.599
4.88
0.99
1.12e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC1806 ZSTK474 3 72
sigmoid
sigmoid
HCC1806 ZSTK474 0 3 72
 8 3.162
Inf
0.654
0.0322
1.18
0.65
4.68
0.99
1.03e-06
NA
Inf
0.548
0.958
1.12
0.545
4.88
0.985
3.14e-06
NA
HCC38 CAL-101 1 72
sigmoid
sigmoid
HCC38 idelalisib 0 1 72
 8 1.723
Inf
0.92
0.00328
1.18
0.903
1.47
0.768
0.0125
NA
Inf
0.932
0.997
1.16
0.918
1.48
0.763
0.0133
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA