Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC1806	Dactolisib	1	72	sigmoid	sigmoid	HCC1806 dactolisib 0 1 72	8	2.743	0.135	-0.0744	0.444	0.391	-0.425	0.577	0.986	2.81e-06	NA	0.0977	0.121	0.559	0.093	0.0151	0.619	0.986	2.47e-06	NA
Hs 578T	Pictilisib	2		sigmoid	sigmoid	Hs578T pictilisib 2	8	2.512	1.93	0.45	0.194	0.4	0.333	0.696	0.98	8e-06	NA	1.58	0.446	0.787	0.231	0.381	0.746	0.974	1.74e-05	NA
HCC1806	Dactolisib	2	72	sigmoid	sigmoid	HCC1806 dactolisib 0 2 72	8	2.828	0.145	-0.0528	0.433	0.401	-0.401	0.578	0.986	2.83e-06	NA	0.0977	0.121	0.559	0.0929	0.0151	0.619	0.986	2.47e-06	NA
HCC70	Torin2	2	72	sigmoid	sigmoid	HCC70 Torin2 0 2 72	8	1.826	0.0342	-0.522	0.671	0.401	-1.0	0.446	0.979	9.23e-06	NA	0.0639	0.0733	0.507	0.0639	0.0	0.462	0.969	2.98e-05	NA
HCC70	AZD-6482	3	72	sigmoid	sigmoid	HCC70 AZD6482 0 3 72	8	2.532	1.43	0.435	0.247	0.421	0.226	0.492	0.983	4.63e-06	NA	1.13	0.431	0.729	0.208	0.286	0.5	0.982	6.2e-06	NA
HCC70	AS605240	3	72	sigmoid	sigmoid	HCC70 AS-605240 0 3 72	8	2.447	Inf	0.58	0.112	0.427	0.549	1.18	0.985	3.24e-06	NA	Inf	0.562	0.877	0.345	0.544	1.24	0.982	6.14e-06	NA
HCC1806	Dactolisib	3	72	sigmoid	sigmoid	HCC1806 dactolisib 0 3 72	8	3.196	0.193	0.0324	0.393	0.437	-0.302	0.579	0.986	2.91e-06	NA	0.0977	0.121	0.559	0.093	0.0151	0.619	0.986	2.47e-06	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
HCC38	Omipalisib	2	72	sigmoid	sigmoid	HCC38 omipalisib 0 2 72	8	2.124	0.0404	-0.47	0.634	0.45	-1.0	0.456	0.979	9.71e-06	NA	0.0507	0.0595	0.494	0.0507	0.0	0.556	0.96	6.44e-05	NA
HCC70	GDC-0980	2	72	sigmoid	sigmoid	HCC70 apitolisib 0 2 72	8	1.676	0.318	-0.0849	0.284	0.451	-0.205	0.983	0.976	1.34e-05	NA	0.536	0.27	0.795	0.285	0.252	1.11	0.972	2.28e-05	NA
HCC70	MK2206	3	72	sigmoid	sigmoid	HCC70 MK-2206 0 3 72	8	2.378	1.43	0.423	0.139	0.451	0.39	1.31	0.983	5.28e-06	NA	1.47	0.445	0.859	0.349	0.437	1.44	0.977	1.2e-05	NA
HCC38	BX-912	3	72	sigmoid	sigmoid	HCC38 BX-912 0 3 72	8	1.454	0.422	-0.428	0.365	0.478	-0.433	5.0	0.993	4.02e-07	NA	0.496	0.162	0.778	0.46	0.159	5.0	0.989	1.24e-06	NA
HCC1806	Omipalisib	1	72	sigmoid	sigmoid	HCC1806 omipalisib 0 1 72	8	2.764	0.104	-0.333	0.49	0.508	-0.746	0.577	0.98	8.23e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC70	GDC-0980	3	72	sigmoid	sigmoid	HCC70 apitolisib 0 3 72	8	2.423	0.623	0.206	0.211	0.509	0.0878	0.959	0.986	2.55e-06	NA	0.568	0.293	0.792	0.283	0.266	1.09	0.981	6.41e-06	NA
HCC38	GDC-0980	3	72	sigmoid	sigmoid	HCC38 apitolisib 0 3 72	8	1.437	0.371	-0.0189	0.29	0.513	-0.179	0.946	0.993	3.35e-07	NA	0.96	0.359	0.808	0.393	0.295	0.998	0.993	3.51e-07	NA
HCC70	TGX221	2	72	sigmoid	sigmoid	HCC70 TGX-221 0 2 72	8	1.786	1.77	0.467	0.233	0.531	0.227	0.503	0.948	0.000139	NA	5.85	0.575	0.806	3.44	0.0897	0.372	0.937	0.000249	NA
HCC70	Torin2	3	72	sigmoid	sigmoid	HCC70 Torin2 0 3 72	8	2.425	0.076	-0.384	0.567	0.532	-0.933	0.541	0.988	1.88e-06	NA	0.0694	0.0576	0.51	0.0694	0.0	0.61	0.973	2.02e-05	NA
HCC1806	Omipalisib	2	72	sigmoid	sigmoid	HCC1806 omipalisib 0 2 72	8	2.849	0.112	-0.311	0.479	0.543	-0.739	0.573	0.98	8.07e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC1806	AS605240	1	72	sigmoid	sigmoid	HCC1806 AS-605240 0 1 72	8	2.728	Inf	0.911	0.0128	0.569	0.91	2.8	0.936	0.000262	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC1806	AS605240	2	72	sigmoid	sigmoid	HCC1806 AS-605240 0 2 72	8	2.813	Inf	0.913	0.0124	0.569	0.913	2.8	0.936	0.000261	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC1806	AS605240	3	72	sigmoid	sigmoid	HCC1806 AS-605240 0 3 72	8	3.181	Inf	0.923	0.011	0.57	0.923	2.81	0.936	0.000257	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC70	Pictilisib	1	72	sigmoid	sigmoid	HCC70 pictilisib 0 1 72	8	1.409	0.408	-0.099	0.284	0.578	-0.245	1.14	0.996	7.62e-08	NA	0.888	0.325	0.816	0.477	0.261	1.19	0.995	1.2e-07	NA
BT-549	ZSTK474	1	72	sigmoid	sigmoid	BT549 ZSTK474 0 1 72	8	1.861	0.58	0.213	0.256	0.583	-0.00205	0.771	0.992	5.43e-07	NA	1.12	0.394	0.788	0.428	0.261	0.767	0.989	1.49e-06	NA
HCC38	BX-912	1	72	sigmoid	sigmoid	HCC38 BX-912 0 1 72	8	1.760	0.529	-0.322	0.274	0.591	-0.322	4.49	0.999	1.36e-10	NA	0.584	0.149	0.818	0.541	0.149	4.63	0.999	8.39e-10	NA
HCC38	PI103	1	72	sigmoid	sigmoid	HCC38 PI-103 0 1 72	8	1.782	0.755	0.222	0.201	0.601	0.12	1.2	0.996	4.45e-08	NA	1.39	0.416	0.839	0.494	0.359	1.23	0.995	1.01e-07	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)