Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
Hs 578T PIK-93 3
sigmoid
sigmoid
Hs578T PIK-93 3
 8 2.816
2.36
0.412
0.0884
2.23
0.033
1.2
0.994
1.87e-07
NA
1.89
0.375
0.897
1.42
0.149
1.24
0.991
8.33e-07
NA
HCC38 AZD8055 1 72
sigmoid
sigmoid
HCC38 AZD8055 0 1 72
 8 1.773
0.052
0.151
0.479
0.0381
0.136
1.02
0.992
4.28e-07
NA
0.116
0.375
0.633
0.0313
0.363
0.987
0.993
3.89e-07
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
BT-549 AZD8055 1 72
sigmoid
sigmoid
BT549 AZD8055 0 1 72
 8 1.781
0.0305
0.165
0.526
0.0228
0.14
1.13
0.992
4.7e-07
NA
0.0615
0.382
0.599
0.0189
0.367
1.12
0.994
1.9e-07
NA
BT-549 AZD8055 3 72
sigmoid
sigmoid
BT549 AZD8055 0 3 72
 8 1.757
0.0178
0.159
0.59
0.0122
0.145
0.913
0.942
0.000193
NA
0.0479
0.383
0.555
0.00973
0.372
0.854
0.954
9.74e-05
NA
HCC38 WYE-125132 1 72
sigmoid
sigmoid
HCC38 WYE-132 0 1 72
 8 1.708
0.0604
0.142
0.447
0.0481
0.134
1.36
0.997
3.43e-08
NA
0.115
0.384
0.669
0.0413
0.381
1.4
0.996
6.46e-08
NA
HCC38 AZD8055 3 72
sigmoid
sigmoid
HCC38 AZD8055 0 3 72
 8 1.417
0.0464
0.0327
0.53
0.0463
0.000983
1.04
0.997
4.27e-08
NA
0.157
0.392
0.658
0.041
0.372
1.02
0.996
5.78e-08
NA
HCC70 AZD-6482 1 72
sigmoid
sigmoid
HCC70 AZD6482 0 1 72
 8 1.368
0.0982
0.0128
0.462
0.205
-0.212
0.481
0.975
1.49e-05
NA
0.767
0.394
0.704
0.121
0.305
0.509
0.973
1.9e-05
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
BT-20 WYE-125132 1 72
sigmoid
sigmoid
BT20 WYE-132 0 1 72
 8 2.067
0.0893
0.289
0.402
0.0435
0.256
1.0
0.987
2.28e-06
NA
0.154
0.403
0.647
0.0353
0.375
0.941
0.985
3.56e-06
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC38 Trametinib 1 72
sigmoid
sigmoid
HCC38 trametinib 0 1 72
 8 1.733
0.162
0.196
0.407
0.173
-0.0184
0.559
0.948
0.000139
NA
0.568
0.41
0.686
0.161
0.234
0.501
0.947
0.000151
NA
HCC38 PI103 1 72
sigmoid
sigmoid
HCC38 PI-103 0 1 72
 8 1.782
0.755
0.222
0.201
0.601
0.12
1.2
0.996
4.45e-08
NA
1.39
0.416
0.839
0.494
0.359
1.23
0.995
1.01e-07
NA
BT-549 BX-912 1 72
sigmoid
sigmoid
BT549 BX-912 0 1 72
 8 1.839
0.909
0.247
0.157
0.742
0.24
3.23
0.992
5.95e-07
NA
1.2
0.419
0.872
0.698
0.415
3.25
0.988
1.54e-06
NA
HCC1806 WYE-125132 2 72
sigmoid
sigmoid
HCC1806 WYE-132 0 2 72
 8 2.874
0.872
0.479
0.284
0.045
0.464
0.883
0.997
3.66e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
HCC1806 WYE-125132 3 72
sigmoid
sigmoid
HCC1806 WYE-132 0 3 72
 8 3.242
Inf
0.531
0.255
0.0458
0.517
0.885
0.997
3.48e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
HCC1806 WYE-125132 1 72
sigmoid
sigmoid
HCC1806 WYE-132 0 1 72
 8 2.790
0.603
0.466
0.292
0.0448
0.45
0.883
0.997
3.72e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
Hs 578T AS605240 2
sigmoid
sigmoid
Hs578T AS-605240 2
 8 2.547
1.89
0.43
0.194
1.81
0.011
0.541
0.988
1.81e-06
NA
1.6
0.426
0.784
0.971
0.117
0.532
0.983
4.67e-06
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA