Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
 8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
Hs 578T Dactolisib 2
sigmoid
sigmoid
Hs578T dactolisib 2
 8 2.509
0.0128
-0.0617
0.655
0.0126
0.00741
0.79
0.974
1.78e-05
NA
0.0105
0.15
0.405
0.00638
0.203
1.04
0.985
3.67e-06
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
Hs 578T GDC-0980 2
sigmoid
sigmoid
Hs578T apitolisib 2
 8 2.520
0.176
-0.0558
0.391
0.275
-0.201
0.758
0.997
3.91e-08
NA
0.159
0.151
0.627
0.121
0.1
0.818
0.998
1.45e-08
NA
HCC38 Omipalisib 1 72
sigmoid
sigmoid
HCC38 omipalisib 0 1 72
 8 1.760
0.0231
-0.316
0.672
0.152
-0.638
0.438
0.97
2.61e-05
NA
0.0585
0.151
0.512
0.0499
0.0356
0.465
0.956
8.65e-05
NA
BT-549 Torin2 2 72
sigmoid
sigmoid
BT549 Torin2 0 2 72
 8 1.824
0.00997
-0.281
0.767
0.0212
-0.282
0.594
0.975
1.47e-05
NA
0.0177
0.155
0.438
0.00929
0.188
0.734
0.973
2.02e-05
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
Hs 578T BX-912 2
sigmoid
sigmoid
Hs578T BX-912 2
 8 2.540
1.07
-0.019
0.174
1.79
-0.489
1.33
0.998
6.37e-09
NA
1.01
0.164
0.828
1.01
0.0
1.4
0.996
7.64e-08
NA
Hs 578T Dactolisib 3
sigmoid
sigmoid
Hs578T dactolisib 3
 8 2.837
0.0118
0.0569
0.624
0.00848
0.115
0.799
0.96
6.53e-05
NA
0.00728
0.164
0.377
0.0043
0.212
1.05
0.968
3.34e-05
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
Hs 578T Trametinib 3
sigmoid
sigmoid
Hs578T trametinib 3
 8 2.830
0.0128
0.0657
0.644
0.0112
0.0447
0.702
0.998
4.02e-09
NA
0.00864
0.168
0.366
0.00512
0.157
0.722
0.998
5.57e-09
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
BT-549 Omipalisib 3 72
sigmoid
sigmoid
BT549 omipalisib 0 3 72
 8 1.777
0.0114
-0.23
0.753
0.0162
-0.178
0.879
0.988
1.64e-06
NA
0.0201
0.183
0.459
0.0112
0.208
0.924
0.991
6.53e-07
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
HCC38 Buparlisib 1 72
sigmoid
sigmoid
HCC38 buparlisib 0 1 72
 8 1.738
0.912
-0.226
0.194
1.46
-0.57
1.62
0.999
9.48e-10
NA
1.2
0.192
0.858
1.12
0.0495
1.66
0.998
4.36e-09
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
 8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA