Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC38 | TGX221 | 3 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 3 72 | 8 | 1.484 | 3688.0 | 0.815 | 0.0743 | 320.0 | 0.243 | 0.273 | 0.867 | 0.00233 | NA | 3261706.0 | 0.866 | 0.945 | 320.0 | 0.458 | 0.269 | 0.867 | 0.00238 | NA |
BT-20 | AS605240 | 2 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 2 72 | 8 | 1.846 | 4509270.0 | 0.729 | 0.203 | 320.0 | 0.31 | 0.101 | 0.845 | 0.00373 | NA | 4.4e+12 | 0.764 | 0.821 | 56.5 | 0.46 | 0.101 | 0.843 | 0.00388 | NA |
BT-549 | TGX221 | 3 | 72 | sigmoid | sigmoid | BT549 TGX-221 0 3 72 | 8 | 1.768 | 93790.0 | 0.805 | 0.0889 | 320.0 | 0.356 | 0.22 | 0.707 | 0.0251 | NA | 49050766.0 | 0.834 | 0.923 | 320.0 | 0.461 | 0.214 | 0.703 | 0.0263 | NA |
Hs 578T | AS605240 | 3 | sigmoid | sigmoid | Hs578T AS-605240 3 | 8 | 2.856 | 63.8 | 0.588 | 0.0965 | 0.826 | 0.494 | 1.03 | 0.983 | 4.89e-06 | NA | 5.75 | 0.518 | 0.879 | 0.552 | 0.465 | 1.14 | 0.981 | 6.87e-06 | NA | |
HCC1806 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 2 72 | 8 | 2.817 | Inf | 0.546 | 0.24 | 0.0517 | 0.535 | 1.19 | 0.995 | 1.31e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 3 72 | 8 | 3.185 | Inf | 0.593 | 0.215 | 0.0523 | 0.583 | 1.19 | 0.995 | 1.36e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 1 72 | 8 | 2.732 | Inf | 0.534 | 0.247 | 0.0515 | 0.522 | 1.19 | 0.995 | 1.3e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
Hs 578T | KIN001-244 | 3 | sigmoid | sigmoid | Hs578T KIN001-244 3 | 8 | 2.888 | Inf | 0.866 | 0.00909 | 5.05 | 0.617 | 1.35 | 0.858 | 0.00289 | NA | 50.0 | 0.818 | 0.988 | 5.2 | 0.474 | 1.31 | 0.842 | 0.00391 | NA | |
HCC70 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 1 72 | 8 | 1.345 | 0.0472 | 0.15 | 0.487 | 0.0311 | 0.149 | 0.849 | 0.973 | 1.89e-05 | NA | 0.93 | 0.475 | 0.693 | 0.0276 | 0.475 | 0.854 | 0.973 | 2.05e-05 | NA |
BT-549 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 3 72 | 8 | 1.744 | 8.87 | 0.616 | 0.0979 | 2.2 | 0.324 | 0.749 | 0.993 | 2.93e-07 | NA | 115.0 | 0.69 | 0.918 | 1.91 | 0.476 | 0.744 | 0.993 | 4.19e-07 | NA |
BT-20 | Everolimus | 3 | 72 | flat | flat | BT20 everolimus 0 3 72 | 8 | 2.422 | Inf | 0.475 | 0.456 | 0.0 | 0.475 | 0.01 | 0.602 | 0.0632 | 0.543 | Inf | 0.478 | 0.534 | 0.0 | 0.478 | 0.01 | 0.561 | 0.0844 | 0.534 |
Hs 578T | Sirolimus | 1 | sigmoid | sigmoid | Hs578T rapamycin 1 | 8 | 2.013 | 110643.0 | 0.587 | 0.358 | 0.000237 | 0.432 | 0.1 | 0.879 | 0.00178 | NA | 9.61e+11 | 0.628 | 0.672 | 0.000175 | 0.487 | 0.1 | 0.851 | 0.00332 | NA | |
HCC70 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 2 72 | 8 | 1.726 | 0.107 | 0.323 | 0.391 | 0.0276 | 0.322 | 0.762 | 0.997 | 2.34e-08 | NA | 3.98 | 0.49 | 0.694 | 0.0225 | 0.491 | 0.775 | 0.997 | 1.93e-08 | NA |
HCC70 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 2 72 | 8 | 1.771 | 6.13 | 0.558 | 0.126 | 1.21 | 0.339 | 0.698 | 0.981 | 7.24e-06 | NA | 785.0 | 0.643 | 0.894 | 0.946 | 0.496 | 0.708 | 0.978 | 1.04e-05 | NA |
BT-549 | BX-912 | 3 | 72 | sigmoid | sigmoid | BT549 BX-912 0 3 72 | 8 | 1.728 | 1.0 | 0.335 | 0.109 | 0.758 | 0.332 | 3.91 | 0.993 | 2.87e-07 | NA | 2.46 | 0.497 | 0.916 | 0.73 | 0.496 | 3.92 | 0.992 | 6.03e-07 | NA |
HCC70 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 3 72 | 8 | 2.415 | 3.74 | 0.495 | 0.279 | 0.0352 | 0.496 | 1.02 | 0.994 | 2.6e-07 | NA | 5.73 | 0.495 | 0.709 | 0.0284 | 0.498 | 1.06 | 0.994 | 2.26e-07 | NA |
BT-20 | Sirolimus | 3 | 72 | flat | flat | BT20 rapamycin 0 3 72 | 8 | 2.661 | Inf | 0.54 | 0.46 | 0.0 | 0.54 | 0.01 | NA | NA | 0.54 | Inf | 0.499 | 0.499 | 0.0 | 0.499 | 0.01 | NA | NA | 0.499 |
Hs 578T | Everolimus | 1 | sigmoid | sigmoid | Hs578T everolimus 1 | 8 | 2.030 | 1707115.0 | 0.626 | 0.318 | 0.00576 | 0.429 | 0.1 | 0.895 | 0.00116 | NA | 2.51e+21 | 0.657 | 0.704 | 0.00121 | 0.502 | 0.1 | 0.893 | 0.00124 | NA | |
Hs 578T | CAL-101 | 2 | sigmoid | sigmoid | Hs578T idelalisib 2 | 8 | 2.534 | 57.5 | 0.801 | 0.0636 | 320.0 | -0.507 | 0.408 | 0.979 | 9.58e-06 | NA | Inf | 0.766 | 0.923 | 4.27 | 0.505 | 0.495 | 0.975 | 1.65e-05 | NA | |
HCC1806 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 3 72 | 8 | 3.199 | 74.1 | 0.843 | 0.0434 | 320.0 | -0.491 | 0.468 | 0.981 | 6.96e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.46e-05 | NA |
HCC1806 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 1 72 | 8 | 2.746 | 47.7 | 0.818 | 0.0504 | 320.0 | -0.715 | 0.466 | 0.981 | 7.02e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.46e-05 | NA |
HCC1806 | MK2206 | 2 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 2 72 | 8 | 2.831 | 51.9 | 0.823 | 0.0489 | 320.0 | -0.668 | 0.467 | 0.981 | 7.01e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.45e-05 | NA |
Hs 578T | KIN001-244 | 1 | sigmoid | sigmoid | Hs578T KIN001-244 1 | 8 | 2.041 | 24.7 | 0.739 | 0.0391 | 4.05 | 0.414 | 0.972 | 0.968 | 3.4e-05 | NA | Inf | 0.752 | 0.962 | 3.15 | 0.51 | 0.99 | 0.964 | 4.65e-05 | NA | |
BT-20 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT20 trametinib 0 3 72 | 8 | 2.539 | Inf | 0.64 | 0.208 | 0.104 | 0.541 | 0.392 | 0.967 | 3.69e-05 | NA | Inf | 0.604 | 0.761 | 0.0656 | 0.513 | 0.391 | 0.964 | 4.56e-05 | NA |
BT-20 | Sirolimus | 2 | 72 | flat | flat | BT20 rapamycin 0 2 72 | 8 | 1.952 | Inf | 0.421 | 0.579 | 0.0 | 0.421 | 0.01 | NA | NA | 0.421 | Inf | 0.513 | 0.513 | 0.0 | 0.513 | 0.01 | NA | NA | 0.513 |